... on the metabolism of losartan and human CYP2C9 and rat CYP2C11 activity in vitro. Methods: Different concentrations of apigenin were added to a 100 mmol/l Tris-HCl reaction mixture containing 2 pmol/ml recombinant human CYP2C9.1, 0.25 mg/ml human liver microsomes or 0.5 mg/ml rat liver microsomes to determine...

...Sai-Zhen Chen; Pei-Pei Pan; Shuang-Hu Wang; Jun Luo; Guo-Xin Hu; Shan-Shan Xu; Lu Zhang; Yin-Fei Yu Background: Losartan and glimepiride are commonly used drugs to treat chronic diseases of hypertension and diabetes; they are both substrates of CYP2C9. The aim of the present study...

...M. Spanakis; I.S. Vizirianakis; G. Batzias; I. Niopas Aim: The study investigates the potential interaction of the herbal medicinal product of Rhodiola rosea on the pharmacokinetics of losartan and its active metabolite EXP3174 after concurrent oral administration to rabbits. Materials and Methods...

...Si-Hyung Yang; Jun-Shik Choi; Dong-Hyun Choi The present study was designed to investigate the effects of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (atorvastatin, pravastatin, simvastatin) on the pharmacokinetics of losartan and its active metabolite EXP-3174 in rats...

...Gehan H. Heeba Background/Aims: This study investigates the ameliorative effect of concurrent and pretreatment with angiotensin II receptor blocker, losartan (LOS), against gentamicin (GEN)-induced renal damage . Methods: Rats were divided into five groups: control, LOS group (10 mg/kg/day for 7...

...Sumith Retnamma Panicker; Chandrasekharan Cheranellore Kartha Background/Aims: High glucose (HG) induces monocyte chemoattractant protein-1 (MCP-1) synthesis in endothelial cells through nuclear factor ĸB (NFĸB). We investigated whether curcumin, losartan and sodium salicylate (NaSal) attenuate HG...

...Ankitkumar Harshadrai Merai; Mohammed Asad; V. Satya Prasad The effect of centrally administered losartan, an AT 1 receptor antagonist, on gastric acid secretion and gastric cytoprotection was studied using different models of gastric ulcers, such as acetic acid-induced chronic gastric ulcers...

... induced by 1.0 µl of 1.5 mol/l NaCl without changing basal cardiovascular parameters. Prior AV3V treatment with losartan (10.0 µg) significantly reduced (p < 0.01) the hypertension and tachycardia induced by hypertonic NaCl administration. Thus, AV3V serotonin and angiotensin II-sensitive neurons may...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Angiotensin II receptor antagonist Blood pressure Hypertension Losartan Renin-angiotensin system Original Paper Pharmacology 1996;52:25-29...

... membrane potential was also observed during this phase, when compared with the proestrus and diestrus phases. The AngII-induced uterine contractions were blocked by losartan. Different losartan pD 2 values were observed. PD123319 had no effect on the contractile response to AngII. The results also indicate...

...D. Accorsi-Mendonça; F.M.A. Corrêa; J.A. Anselmo-Franci; A.M. de Oliveira Steroids hormones can influence several functions of the uterus, including agonist-induced contractions. The aim of this work is to study the influence of hormonal replacement on angiotensin II (Ang II) and losartan...

... and ejaculation in men, and delay or prevent orgasm in women. Newly developed antihypertensive drugs should ideally not interfere with the patients’ quality of life including sexual function. This study examined the effects of losartan, a nonpeptide, specific antagonist for type I angiotensin II receptors...