Skip Nav Destination
1-12 of 12
Zhe Wang, Yun Gong, Da-li Zeng, Lian-guo Chen, Gao-tong Lin, Cheng-ke Huang, Wei Sun, Meng-Chun Chen, Guo-xin Hu, Rui-jie Chen
Pharmacology (2016) 98 (3-4): 183–189.
Published Online: 09 June 2016
... on the metabolism of losartan and human CYP2C9 and rat CYP2C11 activity in vitro. Methods: Different concentrations of apigenin were added to a 100 mmol/l Tris-HCl reaction mixture containing 2 pmol/ml recombinant human CYP2C9.1, 0.25 mg/ml human liver microsomes or 0.5 mg/ml rat liver microsomes to determine...
Pharmacology (2015) 95 (3-4): 133–138.
Published Online: 25 March 2015
...Sai-Zhen Chen; Pei-Pei Pan; Shuang-Hu Wang; Jun Luo; Guo-Xin Hu; Shan-Shan Xu; Lu Zhang; Yin-Fei Yu Background: Losartan and glimepiride are commonly used drugs to treat chronic diseases of hypertension and diabetes; they are both substrates of CYP2C9. The aim of the present study...
Pharmacology (2013) 91 (1-2): 112–116.
Published Online: 17 January 2013
...M. Spanakis; I.S. Vizirianakis; G. Batzias; I. Niopas Aim: The study investigates the potential interaction of the herbal medicinal product of Rhodiola rosea on the pharmacokinetics of losartan and its active metabolite EXP3174 after concurrent oral administration to rabbits. Materials and Methods...
Pharmacology (2011) 88 (1-2): 1–9.
Published Online: 25 June 2011
...Si-Hyung Yang; Jun-Shik Choi; Dong-Hyun Choi The present study was designed to investigate the effects of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (atorvastatin, pravastatin, simvastatin) on the pharmacokinetics of losartan and its active metabolite EXP-3174 in rats...
Pharmacology (2011) 87 (3-4): 232–240.
Published Online: 06 April 2011
...Gehan H. Heeba Background/Aims: This study investigates the ameliorative effect of concurrent and pretreatment with angiotensin II receptor blocker, losartan (LOS), against gentamicin (GEN)-induced renal damage . Methods: Rats were divided into five groups: control, LOS group (10 mg/kg/day for 7...
Pharmacology (2010) 85 (1): 18–26.
Published Online: 01 December 2009
...Sumith Retnamma Panicker; Chandrasekharan Cheranellore Kartha Background/Aims: High glucose (HG) induces monocyte chemoattractant protein-1 (MCP-1) synthesis in endothelial cells through nuclear factor ĸB (NFĸB). We investigated whether curcumin, losartan and sodium salicylate (NaSal) attenuate HG...
Pharmacology (2009) 84 (2): 93–98.
Published Online: 15 July 2009
...Ankitkumar Harshadrai Merai; Mohammed Asad; V. Satya Prasad The effect of centrally administered losartan, an AT 1 receptor antagonist, on gastric acid secretion and gastric cytoprotection was studied using different models of gastric ulcers, such as acetic acid-induced chronic gastric ulcers...
Pharmacology (1996) 52 (1): 25–29.
Published Online: 10 June 2008
... for pharmacodynamic studies. Angiotensin II receptor antagonist Blood pressure Hypertension Losartan Renin-angiotensin system 21 04 1995 3 07 1995 10 6 2008 © 1996 S. Karger AG, Basel 1996 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part...
Pharmacology (1997) 54 (2): 98–107.
Published Online: 10 June 2008
... induced by 1.0 µl of 1.5 mol/l NaCl without changing basal cardiovascular parameters. Prior AV3V treatment with losartan (10.0 µg) significantly reduced (p < 0.01) the hypertension and tachycardia induced by hypertonic NaCl administration. Thus, AV3V serotonin and angiotensin II-sensitive neurons may...
Pharmacology (2002) 65 (3): 162–169.
Published Online: 05 June 2002
... membrane potential was also observed during this phase, when compared with the proestrus and diestrus phases. The AngII-induced uterine contractions were blocked by losartan. Different losartan pD 2 values were observed. PD123319 had no effect on the contractile response to AngII. The results also indicate...
Pharmacology (2002) 64 (4): 208–213.
Published Online: 06 March 2002
...D. Accorsi-Mendonça; F.M.A. Corrêa; J.A. Anselmo-Franci; A.M. de Oliveira Steroids hormones can influence several functions of the uterus, including agonist-induced contractions. The aim of this work is to study the influence of hormonal replacement on angiotensin II (Ang II) and losartan...
Paul Chan, Ju-Chi Liu, Yat-Ching Tong, Yi-Jen Chen, Chia-Chen Wang, Brian Tomlinson, Juei-Tang Cheng
Pharmacology (1999) 58 (3): 132–139.
Published Online: 05 February 1999
... and ejaculation in men, and delay or prevent orgasm in women. Newly developed antihypertensive drugs should ideally not interfere with the patients’ quality of life including sexual function. This study examined the effects of losartan, a nonpeptide, specific antagonist for type I angiotensin II receptors...