...Zhih-Cherng Chen; Ja-Ping Shieh; Hsien-Hui Chung; Ching-Hsia Hung; Hung Jung Lin; Juei-Tang Cheng Background/Aims: The role of opioid receptors in the regulation of vascular function remains unclear. In the current study, we evaluated the ability of loperamide, a peripheral opioid receptor agonist...

... from any ideas, methods, instructions or products referred to in the content or advertisements. Wood creosote Antidiarrheal agent Rat Guinea pig Loperamide Original Paper Pharmacology 1993;46:173-180 Norio Ogata Tatsuya Baba Takashi Shibata Research Institute Taiko Pharmaceutical Co., Ltd...

.... Intraduodenal application of sennosides (2 mg/kg body weight) accelerated the half colon transit time from 60 ± 10 (SEM) to 43 ± 7 min. At the same time the ratio of long-spike bursts to short-spike bursts was changed from 0.22 to 10.1. Loperamide, an antidiarrheal agent, had the opposite effect. The overall...

... A + B, rhein-9-anthrone, rhein) simultaneously with the marker accelerated LIT to approximately 50–70 min. The laxative effect was less pronounced after rhein compared with the other compounds. Indometacin, loperamide, and calcium-channel antagonists (verapamil, nifedipine) partially antagonized...

... was compared with that of loperamide. At an ordinary therapeutic dose, wood creosote inhibited the propulsive motility of colon, but not of small intestine. On the other hand, loperamide inhibited the propulsive motility of small intestine, but not of colon. The results indicate that at least a part...