...), a naturally occurring organic acid, has been reported to ameliorate neuroinflammation and oxidative stress for treatment of diabetes-related memory deficits. Here, we explored whether CA pretreatment ameliorated lipopolysaccharide (LPS)-induced depressive-like behaviors in mice by suppressing...

... butyrate (SB) is a sodium form of the endogenous butyrate. It can inhibit proinflammatory responses and oxidative stress in different models of disease. In the present study, we investigated the effect of SB on lipopolysaccharide (LPS)-induced depression-like behaviors, neuroinflammatory response...

... protective effects and associated mechanisms with respect to lipopolysaccharide (LPS)-induced injury in Caenorhabditis elegans . Methods: Worms were stimulated by LPS (100 μg/mL), with baicalin (1, 10, 100 μmol/L), for 24 h. Animal survival rates and behaviors (reversal and omega turn) were then determined...

.... Tauroursodeoxycholic acid (TUDCA), a clinically available agent used to treat cholesterol gallstone and protect neurons against neurodegeneration, has been reported to prevent neuroinflammation and oxidative stress. In this study, we investigated the effect of TUDCA on lipopolysaccharide (LPS)-induced depression-like...

..., but the uncontrolled development of sickness behavior may trigger negative feelings or chronic depressive events. This study aims at investigating the potential effect of pifithrin-μ, an inhibitor of heat shock protein 70 substrate binding activity, on lipopolysaccharide (LPS)-induced sickness response. C57BL/6J mice...

...Amr A. Fouad; Waleed H. Albuali; Iyad Jresat Background/Aims: Lipopolysaccharide (LPS) induces acute lung injury (ALI) through oxidative stress and inflammation. Naringenin exerts antioxidant and anti-inflammatory effects. The possible protective effect of naringenin was investigated against ALI...

...Hye Lyun Jeon; Jae-Myung Yoo; Bo Dam Lee; Su Jin Lee; Eun Jung Sohn; Mee Ree Kim The purpose of this study is to evaluate the effect of N -arachidonoyl serotonin (NA-5HT) on inflammatory response or oxidative stress in RAW264.7 cells exposed to lipopolysaccharide (LPS). When RAW264.7 cells were pre...

... signaling has been shown to improve acute respiratory distress syndrome and protect alveolar epithelial cells from apoptosis. In this study, we explored the effect of Ang-(1-7)/Mas signaling on the expression and activity of ADAM17 and assessed its impact on apoptosis in lipopolysaccharide (LPS)-treated...

... of which are associated with the pathogenesis of acute liver failure (ALF). This study investigated the effects of the chymase inhibitor TY-51469 on lipopolysaccharide (LPS)/ D -galactosamine (GalN)-induced ALF in hamsters. Methods: TY-51469 (10 or 30 mg/kg) or placebo was administered 1 h before the LPS...

...Dong Chuan Zuo; Seok Choi; Pawan Kumar Shahi; Man Yoo Kim; Chan Guk Park; Young Dae Kim; Jun Lee; In Yeoup Chang; Hak-Sun Lee; Su Cheong Yeom; Hey-Jung Moon; Seung-Yong Seong; Insuk So; Jae Yeoul Jun Background and Purpose: Lipopolysaccharide (LPS) induces intestinal dysmotility by alteration...

...Dong Chen; Min Nie; Ming-wen Fan; Zhuan Bian Background:Porphyromonas gingivalis , a major periodontopathic bacterium, is necessary for periodontitis to take place. The lipopolysaccharide (LPS) of P. gingivalis stimulates cytokine secretion in immune cells, and thereby initiates the inflammation...

...F. Marceau; A. Lussier; S. St-Pierre Bacterial lipopolysaccharide (LPS) induces in 5 h a hypotensive response mediated by the B preceptor for kinins in the rabbit, an effect which is not observed in untreated animals. The present study is intended to evaluate the capacity of other acute toxic...

...Maria Alvarez de Sotomayor; Silvia Vega; Carmen Mingorance; Elisa Marhuenda; Maria Dolores Herrera Aims: Statins have been identified as a potentially interesting treatment against sepsis. Here, we study the vascular reactivity of aortae from rats treated with lipopolysaccharide (LPS), 4 mg · kg –1...

...) as well as protein kinase A (PKA) in the regulation of NO synthesis induced by lipopolysaccharide (LPS) treatment. In this study, the role of phorbol 12-myristate 13-acetate (PMA), cholera toxin (CTX), pertussis toxin (PTX), prostaglandin E 2 (PGE 2 ) and norepinephrine (NE) in the regulation...

... epithelial cells were transfected with NF-ĸB luciferase vector, MUC2 or MUC5AC luciferase vectors. Lipopolysaccharide (LPS) significantly increased NF-ĸB activation in NCI-H292 cells, which was inhibited by the pretreatment by pranlukast in a dose-dependent manner. Either LTD 4 or pranlukast alone did...

...Chandrashekhar S. Patil; Vijay Pal Singh; P.S.V. Satyanarayan; Naveen K. Jain; Amarjit Singh; Shrinivas K. Kulkarni Flavonoids, naturally occurring polyphenolic compounds, are known to inhibit both lipopolysaccharide (LPS) stimulated tumor necrosis factor alpha and interleukin 6 release which...

... investigated the direct effect of the drug on the activation of endothelial cells. For this purpose we set up an in vitro system in which cultured valvular endothelial cells (VEC) activated by tumor necrosis factor alpha or lipopolysaccharide were exposed to a monocytic cell line; these conditions induced...