... and upper colon was brown in color in the animals receiving anthranoid laxatives. No visible changes were detectable in the bisacodyl group. Evaluation by light and electron microscopy revealed cytoplasmic degeneration and increased apoptosis in the colonic surface epithelium after all laxatives. Most...

...G. Nusko; B. Schneider; G. Müller; J. Kusche; E.G. Hahn In a retrospective study a cohort of 2,277 patients was defined by colonoscopy. Among other factors it was tested whether in these patients laxative use or the endoscopically diagnosed presence of melanosis coli were risk factors related...

... Environmental risk factors Epidemiology Laxatives Meta-analysis Pharmacology 1993;47(suppl 1):224 233 Amnon Sonnenberg AstridD. Miiller Division of Gastroenterology, Division of Biostatistics and Epidemiology, VA Medical Center and the Medical College of Wisconsin, Milwaukee, Wise., USA Constipation...

... and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Laxatives Chronic constipation Elderly patients Agiolax Lactulose Pharmacology 1993;47(suppl 1):249 252 A.P...

... is: Reassurance and stop current treatment: Patients with a bowel obsession may take laxatives or rectal preparations regularly without need. Increase dietary fibre: Most cases of ‘simple’ constipation respond to increased dietary fibre, possibly with an added supplement of natural bran. Toilet training...

...Stefan A. Müller-Lissner Laxatives are generally well tolerated and may be considered safe drugs. When taken at much higher than the recommended doses (laxative abuse) some side effects may occur (e.g. hypokalemia, metabolic alkalosis, renal tubular damage). It is controversial whether...

...G. Krumbiegel; H.U. Schulz Therapeutic doses of two laxatives (Agiolax® and Sennatin®) were repeatedly administered to 10 healthy volunteers in a two-way change-over design. Blood samples were collected up to 96 h after the first dose, and plasma levels of total aloe-emodin and rhein were...

... absorption in the perfused rat colon was reduced to a comparable extent by local bisacodyl in Vio of the molar concentration of rhein, an active metabolite of sennosides; recovery was delayed after bisacodyl. These results show that the time course of the laxative action of both drugs is different, probably...

...Edmund W. Godding Laxatives are classified according to their actions on the gut, and the special role and use of senna in the treatment of constipation are discussed. Standardised senna is the most physiological of all the non-fibre laxatives and is safe when used in appropriate dosage avoiding...

... from any ideas, methods, instructions or products referred to in the content or advertisements. Laxatives Anthraquinones Sennosides Intestine Rat Electron microscopy Pharmacology 36: suppl. I, pp. 188-193 (1988) © 1988 S. Karger AG. Basel 0031-7 0 12/88/0367-0188S2.75/0 Electron...

... or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Laxatives Sennosides Colon...

... A + B, rhein-9-anthrone, rhein) simultaneously with the marker accelerated LIT to approximately 50–70 min. The laxative effect was less pronounced after rhein compared with the other compounds. Indometacin, loperamide, and calcium-channel antagonists (verapamil, nifedipine) partially antagonized...

...G. Staumont; J. Frexinos; J. Fioramonti; L. Buéno The effects of stimulant laxatives on colonic motility in man still remain controversial. Stimulation of peristalsis or a decrease of intraluminal pressure has been described manometrically after intraluminal administration of laxatives including...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Laxatives Anthraquinones Sennosides Toxicity, acute, subacute and chronic Reproduction Mutagenicity Toxicology...