...R.D.E. Rumsey; P.E. Squires; N.W. Read The effect of sodium rhein on contractile activity and fluid flow in the rat complete large intestine was studied in vitro. Contractile activity was recorded using serosal strain gauges and volume transducers recorded distal fluid flow from the segment...

...Elke Leng-Peschlow Oral and intracecal administration of bisacodyl or sennosides A + B (10–100 mg/kg each) to rats induced a similar quantity of soft feces within 24 h and a similar acceleration of large intestinal transit time, but in each case bisacodyl had a prolonged action. Net fluid...

... that laxative drug conjugates present in the intestinal lumen in vivo may stem from a pool formed and secreted by the gut, in addition to that one excreted in bile. Danthron Rhein Anthraquinones Metabolism Small intestine Large intestine Drug transport Rat © 1988 S. Karger AG, Basel 1988...

...Elke Leng-Peschlow The effect of pure sennosides A + B on large intestinal transit (LIT) was investigated in the rat. LIT was defined as the time from intracecal administration of a color marker through a chronically implanted catheter until first appearance of colored feces. Sennosides (50 mg/kg...

...S. Guarini Heparin sodium, dissolved in water, causes plasma clearing activity (PC) and appreciable heparinemia (HE) when directly delivered into the duodenum, the jejunum, the ileum or the large intestine of rats, as well as when administered through an esophageal tube to distal duodenum-ligated...