... muscle. Electrical field stimulation Smooth muscle Nitric oxide Calcium K + channels G protein 4-Aminopyridine Off-contraction On-contraction Esophagus © 2009 S. Karger AG, Basel 2009 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication...

...M. Schwanstecher; K. Männer; U. Panten In isolated pancreatic islets of mice, the relationships between free glimepiride concentration and membrane binding or inhibition of ATP-sensitive K + channels were examined. Microsomal membrane binding and K + channel inhibition were half-maximal at 0.7...

...-sensitive A-type K + channel blocker, dendrotoxin, but no other type of K + channel blockers, i.e. iberiotoxin, charybdotoxin or glibenclamide. These findings suggest that cannabinoid receptors inhibit Ca 2+ influx into rat brain nerves via the activation of CB1 receptors and the opening of voltage...

... contracted with phenylephrine. On the other hand, in 2K arteries, the relaxation induced by acetylcholine was abolished. The combination of ODQ and K + channel blockers charybdotoxin (100 nmol/l), apamin (500 nmol/l) and 4-aminopyridine (1 µmol/l) abolished the relaxation induced by acetylcholine in 2K...

...Chaw-Chi Chiu; Jiunn-Ren Wu; Chih-Hsiung Lee; Shwu-Fen Liou; Zen-Kong Dai; Ing-Jun Chen; Jwu-Lai Yeh The antihypertensive effect of vanylidilol, a new α/β-adrenoceptor antagonist with endothelium-dependent and K + -channel-opening activities, was investigated in normotensive and hypertensive Wistar...

..., diltiazem and verapamil in either endothelium-intact or endothelium-denuded rat mesenteric artery rings. In contrast, 17β-estradiol at 3 nmol/l significantly attenuated the relaxation induced by K + channel openers, cromakalim and pinacidil in endothelium-denuded rings. Similarly, preincubation...

...Jung-Ae Kim; Young Shin Kang; Mi-Wha Jung; Ga-Hwa Kang; Sun Hee Lee; Yong Soo Lee Apoptosis appears to be implicated in the pathogenesis and therapeutic applications of cancer. In this study we investigated the induction of apoptosis by 4-aminopyridine (4-AP), a K + channel blocker, and its...

... to in the content or advertisements. Tetrapentylammonium K + channels Ca 2+ channels Contraction Relaxation Smooth muscle Mesenteric artery (rat) Original Paper Pharmacology 1998;57:188 195 Received: September 29, 1997 Accepted: March 14, 1998 K.H. Kwok N.W.K. Chan C.W. Lau Yu Huang Department...