... myocardial infarction (MI) induced by isoproterenol (ISO). Methods: Animals were divided into 6 groups: group I (control group), group II (ISO-treated), group III (1.0 mg/kg/day RPG and ISO-treated), group IV (2.5 mg/kg/day RPG and ISO-treated), group V (5.0 mg/kg/day RPG and ISO-treated), and group VI...

...Mingli Zhong; Hongmin Zhou; Chaoliang Long; Yanfang Zhang; Wenyu Cui; Hao Zhang; Hai Wang The pharmacological effects and underlying mechanisms of natakalim, a novel SUR2B/Kir6.1-K ATP channel opener, against chronic heart failure induced by isoproterenol in rats were investigated. Male Wistar rats...

... into control (n = 8) and post-AMI (n = 13). Myocardial injury was induced by 2 daily doses of 150 mg·kg –1 isoproterenol (ISP). Subcutaneous ECG leads were implanted, and 2 days following the second injection, each rat was dosed with 25 mg·kg –1 verapamil per os, and an ECG was recorded over 4 h after dosing...

... cardiac depression. Using isolated, Langendorff-perfused rat hearts, we determined the effects of intracoronary nitroprusside (NP, 1 and 10 m M ) in the absence and presence of isoproterenol (ISO, 10 –8 M) on cardiac function, O 2 consumption, cyclic GMP and cyclic AMP. ISO, with and without NP, increased...

..., and that this association would be increased with isoproterenol stimulation. Anesthetized open-chest dogs were studied during control (n = 7) or isoproterenol (0.5 µg/kg/min) infusion (n = 7) to test this hypothesis. Coronary blood flow was measured with radioactive microspheres, and cAMP was determined with a competitive...

... on an attempt to increase the size of this response. Washed erythrocytes from reserpine-treated (1 mg/kg daily i.m. for 3 days) and control birds were incubated for 40 min in the presence of isoproterenol 10 –6 mol/l. The activity of CA expressed as Wilbur-Anderson units/mg hemoglobin was increased by as much...

...Soosaiah Gunasekaran; Judith A. Young; Thomas E. Tenner, Jr. The present study was undertaken to compare the cardiomyopathies induced by experimental diabetes mellitus and chronic isoproterenol (ISO) pretreatment on inotropic reactivity of right ventricular strips from rats. One month after...

...U.S. Schwertschlag; B.J. Cerimele; J.L. McNay; R.R. Bowsher; H. Rowe The effect of the phosphodiesterase inhibitors (tibenelast, theophylline) and placebo on isoproterenol-induced changes in heart rate, cAMP and norepinephrine levels in normal male volunteers was studied. Heart rates in response...

... (H 2 O 2 ) and examined its prevention with isoproterenol. Pulmonary arterial pressure (Ppa) and the fluid filtration coefficient (K f ) were measured as indices of lung injury. Rabbits were divided into two groups, and 7 mmol/l H 2 O 2 was administered in both groups. In one group, isoproterenol (2...

... by these drugs included: (1) isoproterenol decreased the duration of a whole BP cycle (Wd), duration of the diastolic wave (Dd), peak amplitude of the systolic wave (SYa), amplitude of the diastolic notch (DNa), amplitude of the diastolic wave (DWa), pulse pressure (dp) and mean arterial pressure (mp...

...Dennis L. Kelleher; Melvin J. Fregly Earlier studies have shown that chronic treatment with estradiol benzoate reduced the responsiveness of heart rate, drinking, and tail-skin temperature to administration of the beta-adrenergic agonist, isoproterenol. The objective of the present study...

...Bobbe L. Ferraiolo; Magnus M. Halldin; Yael Asscher; Yasuo Akita; Kenneth L. Melmon; Leslie Z. Benet; Neal Castagnoli, Jr. β-Adrenergic agonist analogs (congeners) of isoproterenol in which the N-isopropyl group has been linked to a p -methyl- (119) or p -trifluoromethyl- (143) anilide moiety...

...Naoki Inagaki; Toru Miura; Michio Daikoku; Hiroichi Nagai; Akihide Koda The effects of isoproterenol, salbutamol, theophylline, and forskolin on IgE antibody-mediated homologous passive cutaneous anaphylaxis (PCA) and on skin reactions caused by allergic mediators and mediator releasers were...

...Michael J. Katovich; Christopher C. Barney; Elisabeth Larsen A possible interaction between the opiate and β-adrenergic systems in controlling body temperature, heart rate and water intake was investigated using adult male Sprague-Dawley rats. Peripheral administration of isoproterenol (8 and 50 µg...

... temperature) and cardiovascular responsiveness (change in heart rate) to subcutaneous administration of the β-adrenergic agonist, isoproterenol, were significantly prolonged while α 2 -adrenoceptor number (cerebral cortical membranes; 3 H-yohimbine binding) was reduced in rats receiving Tyr. In the second...

...Melvin J. Fregly The skin of the tail of the rat responds to acute administration of isoproterenol, a β 1 - and β 2 -adrenergic agonist, with an increase in temperature that is proportional to the dose administered. The objective of this study was to attempt a characterization of the subtype of β...

... and reduced the coronary flow rate, but had no influence on the frequency and the oxygen consumption. The positive inotropic action of K-strophanthin and isoproterenol was slightly strengthened, whereas the β-adrenergic antagonism by propranolol and the vasodilatation by glycerol trinitrate remained unchanged...

...Edward E. Soltis; Michael J. Katovich Rat aortic smooth muscle responsiveness to potassium chloride and isoproterenol in the presence of the α-adrenergic blocker phentolamine was investigated. A significant decrease in the response of the vascular smooth muscle of aorta to low concentrations...

.... Renal hypertension Tyrosine Drinking Food intake Tail skin temperature Vascular reactivity Phenylephrine Isoproterenol Pharmacology 31: 132-149 (1985) Effect of l-p-Tyrosine on the Development of Renal Hypertension in Rats Ora E. Lockley, Melvin J. Fregly, Dennis C. Eater Department...

...Thomas H. Arnold; Randall L. Tackett Studies have shown that alterations of the magnesium (Mg 2+ ) concentration can alter the response of certain vasoactive compounds. Responses of rabbit thoracic aorta to verapamil, diltiazem, nitroglycerin and isoproterenol were examined in zero Mg 2+ (0.0 M...