... permeability. However, whether lubiprostone has a direct effect on the epithelial barrier function and how it modulates the intestinal barrier function remain unknown. Therefore, the effects of lubiprostone on intestinal barrier function were evaluated in vitro. Methods: Caco-2 cells were used to assess...

... preparations in isolated organ experiments. Cinnamaldehyde Capsaicin TRPA1 Intestine Urinary bladder © 2019 S. Karger AG, Basel 2019 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced...

..., is one of the well-known effects of these products. It is most probably the result of an interaction between apoptotic epithelial cells and the lamina propria cellular infiltrate. Treatment of cell suspensions of intestinal epithelial cells and of human intestinal epithelial cells in culture with rhein...

.... Wood Department of Physiology, Ohio State University College of Medicine, Columbus, Ohio, USA Neuro-lmmunophysiology of Colon Function Key Words Enteric nervous system Myenteric plexus Neuro-immunology Intestine Histamine Serotonin Abstract Neuroimmunophysiology involves direct communication be­ tween...

... and gastrointestinal, liver, kidney or adrenal tumors in the rat. 11 6 2008 Laxative Sennosides Carcinogenicity Rat Intestine Pharmacology 1993;47(suppl 1):209 215 A. Lyden-Sokolowski A. Nilsson P. Sjoberg Medical Products Agency, Division of Pharmacology and Toxicology, Uppsala, Sweden Two-Year...

...Francesco Capasso; Angelo A. Izzo; Nicola Mascolo; Giuseppina Autore; Giulia Di Carlo The effect of in vivo treatment with senna was examined on the ex vivo formation of platelet-activating factor (PAF) by small and large intestine of rat, mouse and guinea pig. A single or a prolonged oral...

...Michiyo Toyoda; Norio Ogata; Takashi Shibata Wood creosote, a mixture of phenolic compounds, suppresses in vitro contractions of rat intestine. To identify a compound in wood creosote able to inhibit intestinal motility, we screened its constituent phenolic compounds and found 4-ethylguaiacol (4-EG...

... Medical College, Taipei, Taiwan, Republic of China Comparison of Two Orogastric Feeding Markers for Measuring Gastrointestinal Motor Functions in Rats Key Words Gastric emptying Gastrointestinal motility Gastrointestinal transit Intestine Stomach Abstract Rat gastrointestinal (GI) transit parameters...

... ± 75 (ileum), 198 ± 93 (colon) and 39 ± 23 (liver). Phenol sulphotransferase is the predominant pathway in the liver, whereas catechol sulphotransferase is the predominant pathway in the intestine. The ileum catalysed the sulphation of p-nitrophenol and dopamine at a higher rate than the colon...

...[a]pyrene hydroxylase (BPH), and uridine-5’-diphosphoglucuronic acid (UDPGA) transferase were unchanged. There were no differences in small intestinal cytochrome P-450 or BPH attributable to diet. Additional rats given an oral dose of 14 C-7,12-dimethyl-benz[a]anthracene ( 14 C-DMBA) after 28 days...

..., instructions or products referred to in the content or advertisements. Images, display Intestine Radiography Colon motility Colon manometry Pharmacology 36: suppl. 1, pp. 66-72 (1988) © 1988 S. Karger AG. Basel 0 031-7 0 1 2/88/0367-0066S2.75/0 Combined Manometric and Radiological Study...

... to point out identical data. In a first histological and ultrastructural study in mouse, we were unable to find any intestinal mucosa injury after long-term sennoside ingestion. In a second long-term experiment, we compared the effects of sennosides and 1,8-dihydroxyanthraquinone (synthetic anthracene...

... from any ideas, methods, instructions or products referred to in the content or advertisements. Laxatives Anthraquinones Sennosides Intestine Rat Electron microscopy Pharmacology 36: suppl. I, pp. 188-193 (1988) © 1988 S. Karger AG. Basel 0031-7 0 12/88/0367-0188S2.75/0 Electron...

...Gian Maria Pacifici; Lucio Giuliani; Roberto Calcaprina The glucuronyl transferase activity was measured with 1 -naphthol as a substrate in nuclear and microsomal fractions of the human intestinal mucosa. The mucosa was obtained from different parts of the intestine. The rate of 1-naphthol...

...Sidney J. Stohs; Christine L.J. Wu The effects of four solvents and 37 xenobiotics and endogenous steroids on intestinal and hepatic microsomal aryl hydrocarbon hydroxylase (AHH) activity were determined. In general, hepatic AHH was more sensitive than intestinal AHH to inhibition by a wide variety...

...Eino Hietanen The metabolism of 3,4-benzopyrene in the wall of isolated everted intestinal sacs was studied in control and 3-methylcholanthrene-induced rats. The luminal (outer) side of the intestine was perfused with a 100-μmol/l concentration of 3,4-benzopyrene in Krebs-Ringer’s bicarbonate...

..., able to maintain or increase mucosal hydroxylative enzymes and UDP glucuronosyltransferase. These results indicate that the drug-metabolizing enzymes of the intestinal mucosa behave very differently from those in the liver. Diet apparently has a regulatory effect on the induction of drug-metabolizing...

...Eino Hietanen Sex variation of drug-metabolizing enzymes was studied in liver and small intestine of Wistar rats. Hydroxylation of 3,4-benzρyrene was much lower in female than in male liver microsomes, but glucuronidation of p-nitrophenol was rather stable in both sexes. Intestinal activities...

...Norio Ogata; Takashi Shibata Wood creosote, a mixture of phenolic compounds, inhibits enterotoxin-induced intestinal fluid secretion, suggesting that one of its constituents suppresses transepithelial Cl – secretion from the intestinal mucosa. To identify an active constituent in wood creosote...