... extract (AAE) on hypertension and insulin resistance induced by the treatment of high-fat diet (HFD) to spontaneously hypertensive rats (SHRs). Then, we investigated the mechanisms associated with the effects of AAE. Methods: AAE was administered to HFD-fed SHRs. Systolic blood pressure (SBP), sympathetic...

...Bhavimani Guru; Akhilesh K. Tamrakar; Subhankar P. Mandal; Prashantha B.R. Kumar; Aditya Sharma; Santhepete Nanjundaiah Manjula Introduction: Peroxisome proliferator-activated receptor gamma (PPARγ) agonists are highly effective in treating insulin resistance. However, associated side effects...

...) in the last four weeks of feeding HFrHFD. Results: The results showed significant improvement in the insulin sensitivity of pioglitazone-treated mice as manifested by significant reduction in the insulin resistance index. This improvement in insulin sensitivity was associated with significant increases...

...Mu-chao Wu; Wei-ran Ye; Yi-jia Zheng; Shan-shan Zhang Metformin (MET) is the first-line drug for treating type 2 diabetes mellitus (T2DM). However, MET increases blood lactate levels in patients with T2DM. Lactate possesses proinflammatory properties and causes insulin resistance (IR). Oxamate (OXA...

... adipogenesis in normal cells, but an increment of TG accumulation was observed on insulin-resistant adipocytes (80%) when compared with resistant control. L-CA also stimulated glucose analog 2-NBDG uptakes on insulin-resistant adipocytes in a similar way as insulin when compared to insulin-resistant cells. Our...

...Ruining Zhang; Suyun Liu; Bingyan Guo; Liang Chang; Yongjun Li Aims: Chemerin is a novel adipokine that is closely associated with cardiovascular diseases and glucose homeostasis. This study aimed to investigate the effects of chemerin on insulin resistance in rat cardiomyocytes. Methods: Rat...

...Wei Yun Zhang; Jung-Jin Lee; In-Su Kim; Yohan Kim; Chang-Seon Myung Agents that stimulate glucose uptake and improve insulin resistance may be useful in the management of type 2 diabetes mellitus (DM). Thus, the aims of this study were to assess the effects of aromadendrin, a flavonoid from...

...Antonieta Gómez-Solís; Ricardo De la Cruz-Cordero; Anaguiven Avalos-Soriano; Miguel Angel Duarte-Vázquez; Jorge Reyes-Esparza; Lourdes Rodríguez-Fragoso Aim: To evaluate the efficacy and safety of 2 analogs of L -carnitine on rats made insulin resistant by a high-fructose diet. Methods: Using rats...

... from any ideas, methods, instructions or products referred to in the content or advertisements. 20 01 2009 1 06 2009 5 9 2009 Adipocytokines, inflammatory Adiponectin Insulin resistance Pioglitazone Resistin Original Paper Pharmacology 2009;84:203 210 DOI: 10.1159...

...Yukiko Ichida; Goji Hasegawa; Michiaki Fukui; Hiroshi Obayashi; Mitsuhiro Ohta; Aya Fujinami; Kiyoe Ohta; Koji Nakano; Toshikazu Yoshikawa; Naoto Nakamura Resistin is a novel cysteine-rich protein that plays a role in the development of insulin resistance and atherosclerosis. HMG-CoA reductase...

... of the vasculature is altered in the db/db mouse. Since this mouse is a model of type II diabetes this may be a consequence of hyperglycaemia and/or insulin resistance. 15 4 1998 1998 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated...