... effects of curcumin as a potential therapeutic agent in protection against the progression of FSGS and indicate that it is mitigated by inhibition of oxidant injury and inflammation and also by promotion of antioxidants. Curcumin ameliorated the ADR-induced FSGS in murine models. It may be a promising...

... to in the content or advertisements. 2024 Chronic kidney disease Adipose mesenchymal stem cells Exosomes Inflammation Apoptosis The global incidence of chronic kidney disease (CKD) is about 10%, and approximately, 7 million people proceed to end-stage renal disease [ 1 ]. The long duration...

... downregulation of p-p65/p65 and p-IκB-α/IκB-α protein expression, alongside significant upregulation of Nrf2 protein expression in the lung tissues of mice treated with CR ( p < 0.01). Conclusion: In summary, CR effectively enhances lung function, minimizes lung tissue damage, and inhibits inflammation...

... and migration of VSMCs can lead to neointimal hyperplasia after vascular injury. Abnormal hyperplasia of neointima and inflammation are one of the main features of atherosclerosis. Therefore, targeting TCF21 may become a potential treatment for relieving atherosclerosis. Key Messages: TCF21 as a member of basic...

... as folk medicine to cure different diseases due to its anti-inflammatory, antibacterial, antioxidant, antifungal, and antitumor effects. To find bioactive medicinal herbs exerting a protective effect on airway inflammation and remodeling, we assessed the anti-oxidative and anti-inflammatory effects...

...Wei Zhu; Lorenz S. Neuwirth; Patrick Cadet Introduction: Oxidative stress and inflammation are major factors contributing to the progressive death of dopaminergic neurons in Parkinson’s disease (PD). Recent studies have demonstrated that morphine’s biosynthetic pathway, coupled with nitric oxide...

... in response to severe stress and inflammation [ 34, 43, 44 ]. These data reveal that AGM has excellent protective properties against inflammatory response. The anti-inflammatory effects of AGM seem to be mediated through inhibiting the secretion of cytokines from inflammatory cells and the suppression...

... somnifera Inflammation Withanolides Alkaloids The therapeutic properties of Withania somnifera (L.) Dunal (WS, family: Solanaceae ) have been widely investigated at pre-clinical and clinical level [ 1 ]. WS extracts (WSEs) were reported to induce beneficial effects on inflammation-based...

... inflammation and barrier function were also evaluated. Results: LAF treatment prevented anorexia and weight loss in rats and ameliorated reductions in hemoglobin, hematocrit, total protein, and albumin levels. LAF reduced the severity of IND-induced intestinal damage including macroscopic and histopathological...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. 2023 Sitagliptin Allergic rhinitis Degranulation Inflammation Histamine Allergic rhinitis (AR) is a type I allergy mediated by immunoglobulin (Ig) E, featuring paroxysmal...

... that recognizes a peptide of glucose 6-phosphate isomerase (GPI), with mice having the MHC class II molecule I-Ag7. These F1 mice spontaneously produce anti-GPI which can then interact with the GPI surrounding the joints and cause severe inflammation and arthritis [ 12, 14, 15 ]. KRN mice on a C57BL/6 background...

...Kazuo Nakamoto; Shogo Tokuyama Introduction: Our previous study demonstrated that docosahexaenoic acid (DHA), an endogenous G protein-coupled receptor 120 (GPR120)/free fatty acid receptor (FFAR) 4 agonist, attenuated the liver inflammation in nonalcoholic steatohepatitis (NASH), while exacerbated...

.... 2022 Asperulosidic acid Inflammation Gestational diabetes mellitus NF-κB Mitogen-activated protein kinase Gestational diabetes mellitus (GDM) is a diabetic condition where glucose intolerance is first recognized during pregnancy [ 1, 2 ]. Most pregnancies with GDM are without obvious...

... with apoptosis, inflammation, and the Toll-like receptor 4/myeloid differentiation factor 88/nuclear factor kappa B (TLR4/MyD88/NF-κB) signalling pathway were detected by Western blot analysis. The RR, PR, QRS, and QTc intervals were assessed by surface ECG. The 90% action potential duration (APD 90 ), threshold...

...Naseratun Nessa; Miyuki Kobara; Hiroe Toba; Tetsuya Adachi; Toshiro Yamamoto; Narisato Kanamura; Giuseppe Pezzotti; Tetsuo Nakata Introduction: Periodontitis is a lifestyle-related disease that is characterized by chronic inflammation in gingival tissue. Febuxostat, a xanthine oxidase inhibitor...

..., IL-6, caspase-3, and caspase-9 in chondrocytes was analyzed by RT-qPCR or Western blot. Results: We found that LPS led to inflammatory responses, cell apoptosis, and increased miR-155 expression in human articular chondrocytes. Tanshinone IIA could inhibit LPS-induced inflammation and cell apoptosis...

...Qianyu Yue; Tian Liu; Zhongfeng Cheng Introduction: Acute lung injury (ALI), a commonly detected syndrome, is characterized by the accumulation of neutrophils and leucocytes, and inflammation of pulmonary tissues. Objective: The present study was designed to investigate the effect and underlying...

...Ji Huang; Chang Liu; Xiu-Fen Ming; Zhihong Yang Background: Adipose tissue inflammation occurs not only in obesity but also in aging and is mechanistically linked with age-associated diseases. Studies show that ablation of the l-arginine-metabolizing enzyme arginase-II (Arg-II) reduces adipose...

... oxidative stress, mitochondrial dysfunction, neuro-inflammation, and even apoptosis and cell death. Principally, toll-like receptors (TLRs) could regulate the inflammatory/anti-inflammatory balance in patients with radiation-induced brain injury. Vinpocetine has an anti-inflammatory effect as shown in both...

..., instructions or products referred to in the content or advertisements. Ganoderic acid A Transforming growth factor -β Smad-3 Nuclear factor kappa B Lung fibrosis Inflammation Bleomycin (BLM) and other clinical anticancer drugs can promote pulmonary fibrosis to some extent, so BLM is often...