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Keywords: Indometacin
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Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1997) 54 (6): 285–297.
Published Online: 10 June 2008
... and least effective on TF hyperalgesia, while indometacin and morphine produced their main effect on TF hyperalgesia. The four drugs were about equally effective in reversing HP hyperalgesia. We conclude that ET hyperalgesia is mediated by both prostaglandin-sensitive and prostaglandin-independent...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1997) 54 (6): 298–304.
Published Online: 10 June 2008
...A. Çorak; T. Coşkun; I. Alican; H. Kurtel; B.Ç. Yeğen The aim of the present study was to investigate the effect of nitric oxide (NO) synthase inhibition on gastric emptying rate in conscious rats and on gastric muscle contractility. The involvement of NO was also investigated in indometacin...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1995) 50 (5): 324–332.
Published Online: 10 June 2008
...Pérez Vallina; B. Cantabrana; A. Hidalgo The effects of the nonsteroidal anti-inflammatory drugs (NSAIDs) acetylsalicylic acid, metamizole, phenylbutazone, indometacin, piroxicam, naproxen, tolmetin, diclofenac, and mefenamic acid on methacholine (10 µmol/l), prostaglandin F 2α (1 µmol/l), and KCl...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1995) 51 (1): 48–55.
Published Online: 10 June 2008
...W.H. Nitter; L.F. Johnsen; M. Eriksen Blood velocity changes in the internal carotid artery were estimated using Doppler ultrasound before, during and after injection of indometacin or placebo in 7 healthy adults. Upon injection of the active substance there was a rapid reduction in blood...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1994) 48 (3): 176–186.
Published Online: 10 June 2008
... of radioactivity originating from 14 C-ethanolamine and from the methyl groups of 3 H-methionine were incorporated into PC. Palmitic acid was incorporated into PC more than PE. Indometacin did not influence the de novo synthesis of PC and PE via the Kennedy pathway, but inhibited the incorporation of 3 H...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1995) 50 (4): 266–272.
Published Online: 10 June 2008
... of zinc on the anti-inflammatory activity of indometacin and diclofenac and their gastric side effects. Oral or subcutaneous administration of zinc (25 and 15 mg/kg, respectively) significantly reduced carrageenan-induced paw edema. Subcutaneous co-administration of zinc (15 mg/kg) and indometacin (5 mg...
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1995) 51 (6): 347–355.
Published Online: 10 June 2008
...Francis K. Darkwa; Donald D. Smyth Indometacin pretreatment potentiates the natriuretic action of the mixed α2-adrenoceptor/imidazoline receptor agonist clonidine. In the present study we determined the effects of indometacin pretreatment on natriuretic actions of the selective I 1 imidazoline...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1991) 43 (4): 220–224.
Published Online: 06 June 2008
... of nitrendipine were not reversible by indometacin or dexamethasone. These results suggest that calcium is important in gastric pathophysiology and that the proof of gastroprotective effects of calcium channel blockers is of great value in the development of new and improved therapies for treatment and prevention...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1991) 42 (5): 287–296.
Published Online: 06 June 2008
...Peter G.F. Cox; Miek M. Moons; Frans G.M. Russel; Cees A.M. van Ginneken We investigated renal handling and effects of indometacin on renal function in the isolated perfused rat kidney (IPK). Indometacin concentrations less than 2.5 ng/ml did not influence renal function, while higher...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1991) 43 (3): 121–127.
Published Online: 06 June 2008
... –8 M , was chosen for further studies. This dose produced close to maximal effects on coronary flow, –22 ± 5%, and developed pressure, –14 ± 5% (mean ± SD). NPY was examined during infusion of the cyclooxygenase inhibitor indometacin (n = 6) and the 5-lipoxygenase inhibitor RG 6866 (N-methyl-4...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1992) 44 (6): 306–314.
Published Online: 06 June 2008
... of the present study was to examine and compare equimolar concentrations of three chemically unrelated cyclooxygenase inhibitors, indometacin (INDO; n = 6), meclofenamate (MECLO; n = 6) and ibuprofen (IBU; n = 5), upon the longitudinal distribution of PVR in the isolated canine lower left lung lobe perfused...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1992) 45 (5): 278–284.
Published Online: 06 June 2008
... (CA) in bone resoφtion, we examined the CA-inhibitory properties of flurbiprofen using bovine and human CA II and compared them with those of acetazolamide and two other NSAIDs, ibuprofen and indometacin. Flurbiprofen inhibited both human and bovine erythrocyte CA II but to a much lesser degree than...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1991) 42 (1): 49–53.
Published Online: 06 June 2008
...B.H. Ali The present experiments examined the protective effect of the nitrofuran drugs, furazolidone (FZ) and nitrofurazone (NF), on duodenal ulceration induced by cysteamine or indometacin in rats. FZ at oral doses of 25, 50 or 100 mg/kg for 2 consecutive days significantly reduced, in a dose...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1989) 39 (2): 98–102.
Published Online: 05 June 2008
... in the drinking water at concentrations of 1 2, 4 or 6 % (v/v) 7 days before the application of stress produced dose-dependent decreases in both the number of ulcers and the ulcer index (UI). These decreases were significant at doses of 4 and 6% (v/v). Indometacin was effective in producing ulcers in the gastric...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1989) 38 (6): 352–362.
Published Online: 05 June 2008
... in the heart. In an attempt to study this problem, two 5-lipoxygenase inhibitors, the novel compound RG 6866, N-methyl-4-benzyloxyphenyl acetohydroxamic acid, and AA 861 have been examined in Langendorff-perfused guinea pig hearts undergoing cardiac anaphylaxis and compared to indometacin and LY 171883...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1989) 39 (6): 350–361.
Published Online: 05 June 2008
...Maikel Raghoebar; Harry L.G.M. Tiemessen; Wim B. van den Berg; Cees A.M. van Ginneken The basic transport properties of indometacin (INDO) were investigated in human blood polymorphonuclear leucocytes (PMNs) of healthy volunteers. The silicone oil cushion centrifugation method was used as ligand...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1988) 36 (Suppl. 1): 85–91.
Published Online: 05 June 2008
... to net secretion, increased potassium secretion and stimulated the release of PGE 2 into the colonic lumen. Inhibition of PG biosynthesis by pretreatment of the rats with indometacin significantly inhibited the effects of senna pod extract both on net fluid transport and on PGE 2 release. The inhibitory...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1988) 36 (Suppl. 1): 40–48.
Published Online: 05 June 2008
... A + B, rhein-9-anthrone, rhein) simultaneously with the marker accelerated LIT to approximately 50–70 min. The laxative effect was less pronounced after rhein compared with the other compounds. Indometacin, loperamide, and calcium-channel antagonists (verapamil, nifedipine) partially antagonized...