... in the pithed rat using two chemical classes of α-adrenoceptor agonists, the phenethylamines and imidazolines, in order to determine if they utilize different signal transduction mechanisms. Pertussis toxin pre-treatment (50 µg/kg, i.v., 3 days prior to experimentation) slightly inhibited the pressor response...

...Jacek Petrusewicz; Roman Kaliszan The effects of seven commonly used imidazoline drugs on human blood platelet aggregation and their inhibitory activity against the adrenaline-induced process were studied. The α-adrenoceptor reacting drugs, prazosin and yohimbine, were used as the standards. Low...