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1-18 of 18
Keywords: Hypoxia
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Journal Articles
Subject Area:
Pharmacology
Journal:
Pharmacology
Pharmacology (2019) 104 (3-4): 147–156.
Published Online: 30 July 2019
...Qiaofeng Chen; Shanpeng Wu; Tianxiang Lu; Jie Chen; Zhitong Xu; Jianting Chen Sulforaphane (SFN) is considered an antioxidant agent, but the biological effects on hypoxia-treated osteoblasts remain unclear. Therefore, the aims of this study were to investigate the effects of SFN on the activity...
Journal Articles
Journal:
Pharmacology
Pharmacology (2019) 103 (5-6): 282–290.
Published Online: 26 February 2019
...Ya-Ning Shi; Xiu-Qin Zhang; Zhe-Yu Hu; Chan-Juan Zhang; Duan-Fang Liao; Hong-Lin Huang; Li Qin Background/Aims: Hypoxia can induce cell injury in cardiomyocytes and further lead to cardiovascular diseases. Genistein (Gen), the predominant isoflavone found in soy products, has shown protective...
Journal Articles
Subject Area:
Pharmacology
Journal:
Pharmacology
Pharmacology (2019) 103 (1-2): 61–67.
Published Online: 16 November 2018
... Hypoxia As the most common benign vascular tumor during infancy, infantile hemangioma (IH) shows distinctive clinical presentations, such as speedy growth followed by subsequent self-limiting disease progress in the early childhood [ 1-3 ]. However, in approximately 10% cases, IH could rapidly...
Journal Articles
Subject Area:
Pharmacology
Journal:
Pharmacology
Pharmacology (2017) 99 (5-6): 275–280.
Published Online: 02 March 2017
...Masashi Tawa; Takashi Shimosato; Hiroshi Sakonjo; Tomio Okamura Background/Aims: Nitroglycerin is widely used as a coronary vasodilator in the treatment of ischemic heart diseases. This study investigated the influence of hypoxia on nitroglycerin-induced relaxation in endothelium-intact...
Journal Articles
Journal:
Pharmacology
Pharmacology (2016) 97 (3-4): 107–113.
Published Online: 06 January 2016
...% higher in 2 groups, respectively, than in the LA group. To study related mechanism, the effects of exposure to chronic high-altitude hypoxia (CHH) on the activity and expression of CYP3A1 were examined in rats. Rats were divided into LA, chronic moderate altitude hypoxia, and CHH groups. CHH caused...
Journal Articles
Subject Area:
Pharmacology
Xiangyang Li, Xuejun Wang, Yongping Li, Ming Yuan, Junbo Zhu, Xiaodong Su, Xingchen Yao, Xueru Fan, Yabin Duan
Journal:
Pharmacology
Pharmacology (2014) 93 (1-2): 76–83.
Published Online: 15 February 2014
...Xiangyang Li; Xuejun Wang; Yongping Li; Ming Yuan; Junbo Zhu; Xiaodong Su; Xingchen Yao; Xueru Fan; Yabin Duan We investigated the effect of exposure to acute and chronic high-altitude hypoxia (AHH and CHH) on the activity and expression of CYP1A2, CYP2D6, CYP2C9, CYP2C19 and NAT2 in rats. The rats...
Journal Articles
Subject Area:
Pharmacology
Journal:
Pharmacology
Pharmacology (2013) 91 (5-6): 322–330.
Published Online: 21 June 2013
...Masashi Tawa; Takashi Shimosato; Ayman Geddawy; Takeshi Imamura; Tomio Okamura Individual vascular beds exhibit differences in vascular reactivity. The present study examined the influence of hypoxia on endothelium-dependent, especially nitric oxide (NO)-mediated, relaxation in the isolated rat...
Journal Articles
Subject Area:
Pharmacology
Journal:
Pharmacology
Pharmacology (2011) 87 (5-6): 265–273.
Published Online: 15 April 2011
.... However, there are few data about the role of TMP in hypoxia-induced pulmonary vascular leakage. This study examined the effect of TMP on hypoxia-induced pulmonary vascular leakage and the underlying mechanisms. Rat pulmonary microvascular endothelial cells (RPMVECs) treated with TMP or not were subjected...
Journal Articles
Subject Area:
Pharmacology
Journal:
Pharmacology
Pharmacology (2009) 84 (1): 17–23.
Published Online: 28 May 2009
... growth and metastasis, has not been determined. Hypoxia regulates a variety of transcription factors including hypoxia-inducible factor (HIF)-1α, which plays a role in the expression of vascular endothelial growth factor (VEGF) and is considered a target for anti-angiogenic therapy. In this study, we...
Journal Articles
Subject Area:
Pharmacology
Journal:
Pharmacology
Pharmacology (1993) 47 (6): 378–385.
Published Online: 10 June 2008
...Patrick du Souich; Denise Hartemann; Claude Saunier The aim of this study was to assess whether moderate hypoxia affects the disposition of diltiazem. Six male beagle dogs received diltiazem (0.6 mg/kg) on three occasions: (1) while breathing air, i.e. during normoxia; (2) 1 h after initiating...
Journal Articles
Subject Area:
Pharmacology
Journal:
Pharmacology
Pharmacology (1988) 36 (3): 151–155.
Published Online: 05 June 2008
...Kazim Türker; Emine Demirel The protective activity of iloprost against hypoxia was studied in isolated rabbit aortic strips precontracted with angiotensin II on the relaxant effect of acetylcholine. Exposure of the strips to hypoxia in the medium of Krebs alone for 48 h caused a highly significant...
Journal Articles
Subject Area:
Pharmacology
Journal:
Pharmacology
Pharmacology (2006) 77 (3): 122–129.
Published Online: 21 July 2006
...Özge Uzun; Abdullah T. Demiryürek The aim of this study was to investigate the effect of hypoxia on and the role of nitric oxide (NO) and cyclooxgenase inhibition in hypoxia-induced vasoconstriction in sheep isolated pulmonary veins. We used the potent pulmonary vasoconstrictor U46619...
Journal Articles
Subject Area:
Pharmacology
Journal:
Pharmacology
Pharmacology (2002) 66 (4): 199–205.
Published Online: 21 October 2002
...Ivo Juránek; Viktor Bauer; Josef Donnerer; Fred Lembeck; Bernhard A. Peskar The present study was designed to test the hypothesis that lack of oxygen in severely hypoxic tissue may inhibit arachidonic acid oxygenation and thereby result in an inhibition of eicosanoid synthesis. Hypoxia was induced...
Journal Articles
Subject Area:
Pharmacology
Journal:
Pharmacology
Pharmacology (2002) 66 (1): 36–43.
Published Online: 07 August 2002
...Carlos R. Tirapelli; Fábio E. Mingatto; Ana M. de Oliveira The purpose of the present study was to investigate the effects of vitamin K 1 on vascular smooth muscle contractility in response to phenylephrine (Phe) during hypoxia. Rat carotid rings were placed in an organ chamber containing Krebs...
Journal Articles
Subject Area:
Pharmacology
Journal:
Pharmacology
Pharmacology (2002) 64 (4): 214–216.
Published Online: 06 March 2002
...Özge Uzun; A. Tuncay Demiryürek; İlker Kanzık The introduction of hypoxia is well known to cause contraction of pulmonary artery rings in vitro. Despite intensive studies, the cellular mechanisms of hypoxic pulmonary vasoconstriction are still not well defined. In this study, we aimed to determine...
Journal Articles
Subject Area:
Pharmacology
Naotsugu Horikawa, Mizue Nishioka, Natsuko Itoh, Yoshikazu Kuribayashi, Kazuki Matsui, Naohito Ohashi
Journal:
Pharmacology
Pharmacology (2001) 63 (2): 76–81.
Published Online: 09 August 2001
... inhibitor, SM-20220 (N-(aminoiminomethyl)-1-methyl-1H-indole-2-carboxamide methanesulfonate). Two hours of hypoxia followed by 24 h of reoxygenation induced lactate dehydrogenase (LDH) release, a marker of cell membrane damage, in cultured neurons and glia derived from rats. SM-20220 significantly reduced...
Journal Articles
Subject Area:
Pharmacology
Journal:
Pharmacology
Pharmacology (1999) 59 (3): 156–164.
Published Online: 29 July 1999
...Catherine Whitbeck; Mark Barreto; Patrick Horan; Sheila S. Levin; Robert M. Levin Purpose: Studies indicate that bladder hypoxia may be an etiological factor for lower urinary tract dysfunction. Rat and rabbit are two species of experimental animals used frequently to study lower urinary tract...
Journal Articles
Subject Area:
Pharmacology
Journal:
Pharmacology
Pharmacology (1998) 57 (3): 139–147.
Published Online: 13 August 1998
...Norio Ohnishi; Shih-Ping Liu; Patrick Horan; Robert M. Levin Purpose: We studied the effects of hypoxia followed by reoxygenation and an in vitro model of ischemia (hypoxia + substrate [glucose] deprivation) followed by reperfusion (reoxygenation + substrate replacement) on the contractile response...