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Keywords: Hypoxia
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Journal Articles
Subject Area:
Pharmacology
Pharmacology (2019) 104 (3-4): 147–156.
Published Online: 30 July 2019
...Qiaofeng Chen; Shanpeng Wu; Tianxiang Lu; Jie Chen; Zhitong Xu; Jianting Chen Sulforaphane (SFN) is considered an antioxidant agent, but the biological effects on hypoxia-treated osteoblasts remain unclear. Therefore, the aims of this study were to investigate the effects of SFN on the activity...
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2019) 103 (1-2): 61–67.
Published Online: 16 November 2018
... Hypoxia As the most common benign vascular tumor during infancy, infantile hemangioma (IH) shows distinctive clinical presentations, such as speedy growth followed by subsequent self-limiting disease progress in the early childhood [ 1-3 ]. However, in approximately 10% cases, IH could rapidly...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2017) 99 (5-6): 275–280.
Published Online: 02 March 2017
...Masashi Tawa; Takashi Shimosato; Hiroshi Sakonjo; Tomio Okamura Background/Aims: Nitroglycerin is widely used as a coronary vasodilator in the treatment of ischemic heart diseases. This study investigated the influence of hypoxia on nitroglycerin-induced relaxation in endothelium-intact...
Journal Articles
Journal Articles
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2011) 87 (5-6): 265–273.
Published Online: 15 April 2011
.... However, there are few data about the role of TMP in hypoxia-induced pulmonary vascular leakage. This study examined the effect of TMP on hypoxia-induced pulmonary vascular leakage and the underlying mechanisms. Rat pulmonary microvascular endothelial cells (RPMVECs) treated with TMP or not were subjected...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2009) 84 (1): 17–23.
Published Online: 28 May 2009
... growth and metastasis, has not been determined. Hypoxia regulates a variety of transcription factors including hypoxia-inducible factor (HIF)-1α, which plays a role in the expression of vascular endothelial growth factor (VEGF) and is considered a target for anti-angiogenic therapy. In this study, we...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1993) 47 (6): 378–385.
Published Online: 10 June 2008
...Patrick du Souich; Denise Hartemann; Claude Saunier The aim of this study was to assess whether moderate hypoxia affects the disposition of diltiazem. Six male beagle dogs received diltiazem (0.6 mg/kg) on three occasions: (1) while breathing air, i.e. during normoxia; (2) 1 h after initiating...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1988) 36 (3): 151–155.
Published Online: 05 June 2008
...Kazim Türker; Emine Demirel The protective activity of iloprost against hypoxia was studied in isolated rabbit aortic strips precontracted with angiotensin II on the relaxant effect of acetylcholine. Exposure of the strips to hypoxia in the medium of Krebs alone for 48 h caused a highly significant...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2006) 77 (3): 122–129.
Published Online: 21 July 2006
...Özge Uzun; Abdullah T. Demiryürek The aim of this study was to investigate the effect of hypoxia on and the role of nitric oxide (NO) and cyclooxgenase inhibition in hypoxia-induced vasoconstriction in sheep isolated pulmonary veins. We used the potent pulmonary vasoconstrictor U46619...
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2002) 66 (1): 36–43.
Published Online: 07 August 2002
...Carlos R. Tirapelli; Fábio E. Mingatto; Ana M. de Oliveira The purpose of the present study was to investigate the effects of vitamin K 1 on vascular smooth muscle contractility in response to phenylephrine (Phe) during hypoxia. Rat carotid rings were placed in an organ chamber containing Krebs...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2002) 64 (4): 214–216.
Published Online: 06 March 2002
...Özge Uzun; A. Tuncay Demiryürek; İlker Kanzık The introduction of hypoxia is well known to cause contraction of pulmonary artery rings in vitro. Despite intensive studies, the cellular mechanisms of hypoxic pulmonary vasoconstriction are still not well defined. In this study, we aimed to determine...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2001) 63 (2): 76–81.
Published Online: 09 August 2001
... inhibitor, SM-20220 (N-(aminoiminomethyl)-1-methyl-1H-indole-2-carboxamide methanesulfonate). Two hours of hypoxia followed by 24 h of reoxygenation induced lactate dehydrogenase (LDH) release, a marker of cell membrane damage, in cultured neurons and glia derived from rats. SM-20220 significantly reduced...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1999) 59 (3): 156–164.
Published Online: 29 July 1999
...Catherine Whitbeck; Mark Barreto; Patrick Horan; Sheila S. Levin; Robert M. Levin Purpose: Studies indicate that bladder hypoxia may be an etiological factor for lower urinary tract dysfunction. Rat and rabbit are two species of experimental animals used frequently to study lower urinary tract...
Journal Articles