...Anthony Kales; Constantin R. Soldatos; Edward O. Bixler; Joyce D. Kales Rebound insomnia and rebound anxiety are clinical conditions related to withdrawal of certain benzodiazepine drugs. Numerous studies of benzodiazepine and nonbenzodiazepine hypnotics conducted in our sleep laboratory...

... midline theta activity. The results suggest that zopiclone possesses a potent hypnotic effect, whereas its anxiolytic potential in humans is probably low. 4 6 2008 © 1983 S. Karger AG, Basel 1983 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part...

...J.C. Blanchard; A. Boireau; L. Julou Zopiclone (ZPC; RP 27,267), which is chemically unrelated to benzodiazepines (BZD), was found to have a similar pharmacological profile and to possess in man hypnotic activity similar to that of some BZD such as nitrazepam. It was, therefore, interesting...

...U.J. Jovanovic; J.F. Dreyfus Zopiclone, a new hypnotic with an original chemical structure, was compared in a sleep laboratory study with nitrazepam according to a double-blind, parallel group randomized design. Zopiclone (7.5 mg) and nitrazepam (5 mg) were each given for 14 nights to 5 insomniacs...

...-life in the range of 10–20 h. Triazolam has an intermediate absorption rate, but is rapidly eliminated (half-life 1.5–5 h) making it essentially non-accumulating. Understanding of the pharmacokinetics of benzodiazepine hypnotics can contribute to understanding of their clinical properties. 4 6...

...P. Simon; I. Boutelier Sedative hypnotics belong to several chemical classes and thus have heterogeneous pharmacodynamic properties. Among various ways of approaches, conventional pharmacology using animal models allows one to define a common pharmacological profile. It still remains the best...

.... Zopiclone Pentobarbitone Hypnotics Insomnia Pharmacology 27: suppl. 2, pp. 188-195 (1983) / Int. Pharmacopsychiat. 17: suppl. 2, pp. 188-195 (1982) © 1983 S. Karger AG, Basel 0031- 7012/83/0278- 0 188S2.75/0 Comparative Study of Zopiclone and Pentobarbitone as Hypnotics A.J. Mello de Paula...

...L. Julou; M.C. Bardone; J.C. Blanchard; C. Garret; J.M. Stutzmann Zopiclone (RP 27 267) is an hypnotic with a chemical structure different from that of the benzodiazepines (BZD) or barbiturates. Studies of zopiclone in classical psycho-pharmacological tests, in comparison with BZD and barbiturates...