... midline theta activity. The results suggest that zopiclone possesses a potent hypnotic effect, whereas its anxiolytic potential in humans is probably low. 4 6 2008 © 1983 S. Karger AG, Basel 1983 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part...

...J.C. Blanchard; A. Boireau; L. Julou Zopiclone (ZPC; RP 27,267), which is chemically unrelated to benzodiazepines (BZD), was found to have a similar pharmacological profile and to possess in man hypnotic activity similar to that of some BZD such as nitrazepam. It was, therefore, interesting...

...U.J. Jovanovic; J.F. Dreyfus Zopiclone, a new hypnotic with an original chemical structure, was compared in a sleep laboratory study with nitrazepam according to a double-blind, parallel group randomized design. Zopiclone (7.5 mg) and nitrazepam (5 mg) were each given for 14 nights to 5 insomniacs...

...-life in the range of 10–20 h. Triazolam has an intermediate absorption rate, but is rapidly eliminated (half-life 1.5–5 h) making it essentially non-accumulating. Understanding of the pharmacokinetics of benzodiazepine hypnotics can contribute to understanding of their clinical properties. 4 6...

...P. Simon; I. Boutelier Sedative hypnotics belong to several chemical classes and thus have heterogeneous pharmacodynamic properties. Among various ways of approaches, conventional pharmacology using animal models allows one to define a common pharmacological profile. It still remains the best...

.... Zopiclone Pentobarbitone Hypnotics Insomnia Pharmacology 27: suppl. 2, pp. 188-195 (1983) / Int. Pharmacopsychiat. 17: suppl. 2, pp. 188-195 (1982) © 1983 S. Karger AG, Basel 0031- 7012/83/0278- 0 188S2.75/0 Comparative Study of Zopiclone and Pentobarbitone as Hypnotics A.J. Mello de Paula...

...L. Julou; M.C. Bardone; J.C. Blanchard; C. Garret; J.M. Stutzmann Zopiclone (RP 27 267) is an hypnotic with a chemical structure different from that of the benzodiazepines (BZD) or barbiturates. Studies of zopiclone in classical psycho-pharmacological tests, in comparison with BZD and barbiturates...

...Anthony Kales; Constantin R. Soldatos; Edward O. Bixler; Joyce D. Kales Rebound insomnia and rebound anxiety are clinical conditions related to withdrawal of certain benzodiazepine drugs. Numerous studies of benzodiazepine and nonbenzodiazepine hypnotics conducted in our sleep laboratory...