... to quantify the relevant genes and proteins. Results: In this study, CANA exhibited diuresis, decreased blood pressure, weight loss, and increased food and water intake. Following a high-salt diet, Dahl salt-sensitive rats developed hypertension followed by left ventricular diastolic dysfunction, myocardial...

... using the ROBINS-1 tool, was high for all included studies. Significant adverse effects reported included hypotension, light-headedness, drowsiness, dry mouth, rebound hypertension, and contact dermatitis from patch application. Short-term clonidine use was associated with significant improvement...

...Takayuki Matsumoto; Keisuke Takayanagi; Tomoki Katome; Mihoka Kojima; Kumiko Taguchi; Tsuneo Kobayashi Introduction: Femoral arterial dysfunction including abnormal vascular responsiveness to endogenous ligands was often seen in arterial hypertension. Extracellular nucleotides including uridine 5...

...Yusuke Watanabe; Kaori Ohata; Ayaka Fukanoki; Naoto Fujimoto; Maruri Matsumoto; Naseratun Nessa; Hiroe Toba; Miyuki Kobara; Tetsuo Nakata Background/Aims: Flaxseed contains alpha-linolenic acid (ALA), lignans, and dietary fiber, and its intake lowers blood pressure in hypertensive patients. Here...

...Yunfeng Zhao; Kun Liu; Delu Yin; Zhaoheng Lin Introduction: Angiotensin II (AngII) induces hypertension and pathophysiological vascular thickening and atherosclerosis. This study aims to validate the effects of Angiopoietin-like 7 (ANGPTL7) in AngII-induced hypertension. Methods: ANGPTL7 in blood...

... stroke research. We have previously demonstrated phenotypic receptor changes to be one of the injurious mechanisms occurring after stroke but mostly in healthy rats. The aim of this study was to investigate if hypertension has an effect on vasoconstrictive receptor responses to endothelin 1, sarafotoxin...

...Hiroe Toba; Jiahong Wang; Makoto Ohigashi; Miyuki Kobara; Tetsuo Nakata Background/Aims: Telmisartan and losartan, angiotensin II type 1 (AT 1 ) receptor antagonists, are used to manage hypertension. We previously reported that telmisartan, a partial agonist of peroxisome proliferator-activated...

...Yolanda Mendizábal; Sílvia Llorens; Eduardo Nava Glitazones exhibit beneficial effects in the vascular system, both on large vessels and at a microcirculatory level. We previously reported the effects of glitazones in the aorta of spontaneously hypertensive rats (SHR). We focus now on the acute...

... overexpression has any regulatory role on blood pressure in a renovascular model of hypertension. We examined the effect of zinc protoporyphyrin IX (ZnPP-IX) administration, an inhibitor of HO activity, on mean arterial pressure (MAP) and heart rate in sham-operated and aorta-coarcted (AC) rats and its...

... expression. Genistein also elevated angiotensin II type 2 receptor (AT2) expression, and the effects of genistein on LVH could be completely abolished by an AT2 antagonist, PD123319. The antagonist also reversed the increase in eNOS activity, NO and cGMP restored by genistein in hypertensive rats. We further...

.... Pregnancy Preeclampsia Adrenoceptors Hypertension Rat Captopril Original Paper Pharmacology 2009;84:367 376 DOI: 10.1159/000258655 Received: May 11, 2009 Accepted after revision: August 25, 2009 Published online: November 14, 2009 Angiotensin-II-Dependent Changes in Alpha-1 Adrenoceptor Vascular...

... hypertension. Thus, these studies reveal that pyridoxine, pyridoxal phosphate and tryptophan are potential antihypertensive agents. © 1995 S. Karger AG, Basel 1995 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages...

...Ravi S. Iyer; Govind Singh; Sam Rebello; Sujoy Roy; Rama Bhat; Dharmapuri Vidyasagar; Anil Gulati The concentration of endothelin-1 (ET-1) in the brain regions, heart, and throacic aorta of 1-, 4-, 6- and 8-week-old spontaneously hypertensive (SHR) and normotensive Wistar-Kyoto (WKY) rats...

... inhibitors) in anaesthetized spontaneously hypertensive rats. Captopril (20 mg/kg) and enalapril (20 mg/kg) administered intravenously caused a significant (p < 0.001) fall in systolic and diastolic blood pressures in the absence of aprotinin. In contrast, captopril (20 mg/kg) and enalapril (20 mg/kg...

... hyperglycemia, hypoinsulinemia, and a lower body weight as compared with control animals but did not show significant abnormalities in cardiovascular function. DOCA-hypertensive STZ-diabetic rats had similar hyperglycemia, milder hypoinsulinemia, and a significantly lower rate of left ventricular relaxation...

... release. Because eprosartan is more effective in inhibiting sympathetic nervous system activity compared to other chemically distinct nonpeptide angiotensin II receptor antagonists, eprosartan may be more effective in lowering systolic blood pressure and in treating isolated systolic hypertension...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Angiotensin II receptor antagonist Blood pressure Hypertension Losartan Renin-angiotensin system Original Paper Pharmacology 1996;52:25-29...

... for the angiotensin II receptor subtype 2. Their antihypertensive activity was established in conscious renal hypertensive rats. BIBS 39, BIBS 222 and DuP 753, when administered intravenously, caused a substantial dose-dependent antihypertensive effect with very similar ED 30 values of approximately 2 mg/kg...

...Ronald E. Weishaar; Clinton Webb; Charles B. Smith α 2 -Adrenoceptors were characterized on neural and vascular membranes from 2-kidney-1-clip renal hypertensive (RHT) and normotensive (NT) rats. Rats were sacrificed 6 weeks after induction of renal ischemia, and the specific binding of 3 H...

..., instructions or products referred to in the content or advertisements. Aldosterone Adrenal glomerulosa Angiotensin II Potassium channels Vasodilators Hypertension Pharmacology 1991;43:141-150 © 1991 S. Karger AG. Basel 0031-7012/91 /0433-0141$2.75/0 Inhibition of Aldosterone Production...