... proteins may be targets of photosensitization by photoactive metalloporphyrins. A decrease in the binding constant of bilirubin to Sn-mesoporphyrin-mediated photosensitized human serum albumin (HSA) was observed following illumination at 50 W/m 2 in the spectral range of 520–700 nm; there were 2.0 ± 0.2...

... agree with previous in vitro studies employing single fatty acids and human serum albumin, suggesting that in vivo plasma composition is not adequately reproduced during in vitro experiments on protein-binding displacement of drugs by FFA. 7 01 1982 29 03 1982 4 6 2008 © 1982 S...

...Klaus J. Fehske; Walter E. Müller The binding of ethacrynic acid to human serum albumin was investigated by means of circular dichroism and equilibrium dialysis measurements, using native human serum albumin and albumin derivatives with chemical modifications impairing specifically drug binding...

...P.A. Schwartz; C.T. Rhodes; D.S. Greene The effect of varying concentrations of sodium oleate on the binding of furosemide to human serum albumin was investigated using continuous ultrafiltration. The furosemide fraction free was 1.37% in the absence of sodium oleate increasing to 3.52...

...Walter E. Müller; Uwe Wollert Most drugs are bound to human serum albumin (HSA) via a few high affinity binding sites and several sites of much lower affinity. There is now increasing evidence that the actual number of high affinity drug-binding sites of HSA is rather small. Thus, each...

...J.N. Costanzo; Z.N. Gaut; J.T. Benedict; H.M. Solomon The fluorescence of DNSA (5-dimethyl-aminonaphthalene-1-sulfonamide) in solution with human serum albumin has been used to study the binding characteristics of DNSA to this protein. Such binding is apparently hydrophobic in nature and occurs...