...Abha Sahni; Erica D. Thomasson; Riya Shah; Sanjeev K. Sahni Cellular oxidative stress in the endothelium of blood vessels leads to several pathophysiological sequelae, including vascular damage and dysfunction, inflammation and atherosclerosis. Heme oxygenase-1 (HO-1) provides protection against...

...Ariel H. Polizio; Diego M. Santa-Cruz; Karina B. Balestrasse; Mariela M. Gironacci; Facundo M. Bertera; Christian Höcht; Carlos A. Taira; Maria L. Tomaro; Susana B. Gorzalczany Heme oxygenase (HO) is an enzyme that is involved in numerous secondary actions. One of its products, CO, seems to have...

... of known dielectric constant, the relative polarity of the microenvironment surrounding a porphyrin can be estimated. We have focused our examination on the ability of two synthetic metalloporphyrin inhibitors of heme oxygenase, Sn(IV)-mesoporphyrin (SnMP) and Zn(Π)-mesoporphyrin (ZnMP), to partition...

...Terry J. Smith; George S. Drummond; Attallah Kappas Treatment of rats with Co-protoporphyrin, a synthetic metalloporphyrin which produces a marked and sustained induction of hepatic heme oxygenase and decline in cellular cytochrome P-450 content, caused a significant reduction in serum testosterone...

...Mohinder K. Sardana; George S. Drummond; Shigeru Sassa; Attallah Kappas The administration of trivalent arsenic, either as sodium arsenite or as the trypanocidal drug melarsoprol, to rats produced a profound induction of microsomal heme oxygenase (EC 1.14.99.3) in both liver and kidney...

...Hui-Chen Lin; Tzu-Hurng Cheng; Yen-Chou Chen; Shu-Hui Juan We previously reported that adenovirus-mediated gene transfer of heme oxygenase-1 (HO-1) inhibits the development of atherosclerosis in apolipoprotein E-deficient mice. This finding implies that HO-1 induction is beneficial for protecting...

...-linked Hb transfusion group, but there were significant reductions in the HbA group. In animals transfused with cross-linked Hbs, splenic heme oxygenase (HO) activity was similar to that of controls; liver HO activity was slightly elevated, whereas HO activity was significantly increased in kidneys...