... and 0.019 mg/ kg, respectively) and bronchoconstriction (ED 50 : 0.0014 and 0.024 mg/kg, respectively) in guinea pigs. Against the bronchoconstriction, here, the inhibitory effect of Y-24180 was significantly more potent and longer acting than that of WEB 2086. On the other hand, Y-24180 (10 mg/kg, p.o...

...Masahiko Kagoshima; Noriko Tomomatsu; Yoshinori Iwahisa; Shuji Yamaguchi; Yukio Kawakami; Michio Terasawa The effect of Y-24180, a potent antagonist to platelet-activating factor (PAF), was evaluated on the antigen-induced immediate asthmatic response (IAR) in actively sensitized guinea pigs...

...) of residual fluid volume in an intestinal loop, and partly by suppression of intestinal motility. Wood creosote also inhibited spontaneous longitudinal contractions of isolated ileal segments in rats (IC50 = 28 mg/l) and guinea pigs (IC50 = 17 mg/l). Contractions of the guinea pig ileum induced by electrical...

...), and the GABA-B antagonists, 3-aminopropyl (diethoxymethyl) phosphinic acid (CGP 35348), 2-hydroxysaclofen and 3-aminopropylphosphonic acid (3-APPA) on cholinergic and peptidergic contractile responses in the airways of guinea pigs. Electrical field stimulation of the isolated guinea pig trachea produced...

...Wasswa E.B. Semafuko; Daniel L. Follett; Walter R. Dixon The effect of etorphine (ET) on nerve stimulation-mediated release of norepinephrine (NE) was investigated in isolated rat and guinea pig hearts. Hearts were perfused with Krebs bicarbonate solution via the aorta and the overflow of NE...

...Thomas Jansson; Bengt Kristiansson; Abubaker Qirbi In order to investigate effects of khat chewing on uteroplacental blood flow (+) norpseudoephedrine (NPE) infusions were given to 11 anesthetized guinea pigs in late pregnancy (62–66 days) after unilateral uterine artery ligation at days 30–32...

..., instructions or products referred to in the content or advertisements. Aspirin Indomethacin Tartrazine Carotid-sinus nerve Pressoreceptors Guinea pig Pharmacology 34: 96-103 (1987) © 1987 S. Karger AG. Basel 0031 -7012/87/0343-0096S2.75/0 Aspirin, Indomethacin, and Tartrazine Increase Carotid...

...Jagdish C. Khatter; Srisala Navaratnam; Robert J. Hoeschen Protective influence of verapamil upon ouabain-induced cardiac arrhythmias was investigated in anesthetized (α-chloralose 60 mg/kg and urethane 500 mg/kg) open-chest guinea pigs. Verapamil in doses between 100 and 150 μg/kg significantly...

...) and an apparent noncompetitive inhibitor of LTC 4 (‘pseudo’ pA 2 = 6.8) in the longitudinal muscle of the guinea pig ileum. At concentrations that effectively antagonize peptidoleukotriene-induced contractions, MDL 43,291 does not antagonize histamine, carbachol or substance P. In vivo, 10–30 mg/kg MDL 43,291...

...G.J. Molderings; H.-J. Schümann In guinea-pig aorta phenylephrine and noradrenaline induced concentration-dependent contractions when β-adrenoceptors were blocked. The contractile response to phenylephrine was amplified by previous application of subthreshold concentrations of 5-hydroxytryptamine...

...Walter Deutschmann; Ernst Lindner; Norbert Deutschländer We studied the influence of a perfluorochemical (PFC) emulsion on the ultrastructure and function of the isolated perfused guinea pig heart compared to a Krebs-Henseleit solution. The PFC perfusion enhanced the force of contraction...

...Jonathan D. Geiger; Gopal Das; Surendra S. Parmar The clinically relevant interaction between quinidine (3 mg/kg) and digoxin (0.6 mg/kg plus 20 μCi 3 H-digoxin) was investigated using unanesthetized and unrestrained guinea pigs for in vivo pharmacokinetic and tissue disposition studies. Quinidine...

...K.-F. Sewing; H. Hannemann In isolated and enriched guinea pig parietal cells the inhibitory effects of the calcium channel antagonists verapamil and gallopamil on 14 C-aminopyrine uptake (= H + secretion) have been analyzed. Both verapamil and gallopamil inhibit acid secretion in a concentration...

... drugs Meseclazone Bradykinin Bronchospasm Guinea pig TXA 2 Prostaglandins Pharmacology 24: 243-247 (1982) Antagonism by Meseclazone and Other Nonsteroidal AntiInflammatory Drugs of Bradykinin-Induced Bronchospasm William Diamantis. James E. Harrison, James L. Perhach, Jr.. R. Duane Sofia...

... fluorometrically. The normal histamine contents of blood, plasma and various organs from guinea pigs are investigated by this procedure. The values obtained are compared with the data in the literature. On comparison of the histamine contents in the organs of guinea pigs of two weight and age classes, significant...

...D. Müller; K.-Fr. Sewing; H.-J. Ruoff In normally fed guinea pigs the effect of a sustained release pentagastrin preparation was studied on gastric mucosal weight, protein, DNA and RNA concentration and thymidine and uridine incorporation into DNA and RNA, respectively. Treatment with pentagastrin...

...O. Förster; A. Lindner; G. Nitulescu; H. Plenk, jr. To facilitate quantitative measurement of a delayed hypersensitivity reaction, a tuberculin reaction was produced in the paws of sensitized guinea pigs and the resulting edema estimated by one of the usual techniques. The edema formation was shown...

...K. Süsskand; K.-F. Sewing In the guinea-pig isolated atrium pirenzepine shifts the concentration response curve of carbachol on frequency towards the right thus indicating that pirenzepine has anticholinergic properties. 29 01 1979 2 03 1979 29 5 2008 © 1979 S. Karger AG...

... tone in vitro. Method: The effect of dipyrone on inositol phosphate (IP) accumulation was evaluated on guinea pig trachea smooth muscle. Changes in intracellular free calcium levels and IP accumulation were evaluated in LTK8 cells. Results: Dipyrone (0.01, 0.1, 1 mmol/l) had a relaxing effect...

...-pretreated dams were within the normal range. Artemether (48–480 µg/ml) had no agonist effect on the isolated uterine smooth muscles of both non-pregnant and pregnant rats and guinea pigs. However, the drug (24– 240 µg/ml) reduced oxytocin-induced contraction of uterine tissues concentration-dependently...