...Alain Munafo; Martha L. Hyneck; Leslie Z. Benet In a previous study, the disposition and irreversible plasma protein binding of tolmetin have been described in young volunteers. Significant levels of tolmetin glucuronide and its isomer(s) were found in plasma, and irreversible binding was shown...

... to increase 15 min after the dose, and they reached their maximum concentrations 30 min after administration. The maximum concentrations of glucuronides were 0.18 ± 0.07,0.91 ± 0.38,0.33 ± 0.18 and 0.47 ± 0.23 mg/l; those of sulfates were 0.16 ± 0.06,0.22 ± 0.09,0.17 ± 0.07 and < 0.04 mg/l for phenol...

...Mierha Yang; Gary P. Carlson Glucuronidation and sulfation of 1-naphthol, 7-hydroxycoumarin, 4-nitrocatechol and phenolphthalein were studied in rabbit lung and liver. Pulmonary UDP-glucuronyltransferase and sulfotransferase activities in subcellular fractions were approximately 20–50% of those...

... of administered dose recovered from urine as acetaminophen sulfate and the partial clearance to acetaminophen sulfate decreased while the fraction recovered as acetaminophen glucuronide and the partial clearance to acetaminophen glucuronide increased with increasing age. Renal clearances of acetaminophen...

.... Endotoxin Low protein diet Mixed function oxidase Glucuronidation Hepatic microsomes Effects, acute and chronic Pharmacology 26: 100-109 (1983) Endotoxin and Low Protein Diet Induced Depression of the Rat Hepatic Drug Metabolism B.R. Sonawane, S.J. Yaffe Departments of Pediatrics and Pharmacology...

..., but methylation and glucuronidation of DES was observed when incubated with microsomes and NADPH and reincubated with Triton, soluble fraction, UDP-glucuronic acid and SAM. Since DES itself was not methylated by the soluble fraction, the results suggest that DES is oxidized by mixed function oxidases...

...Nicole Sabolovic; Tony Heurtaux; Anne-Claude Humbert; Stéphanie Krisa; Jacques Magdalou Background/Aims: Glucuronidation of cis - and trans -resveratrol (3,5,4’-trihydroxy-trans-stilbene), which is a naturally occurring phytoalexin known to exert a number of beneficial health effects...