.... 2021 Calcineurin inhibitors Cyclosporine A Kidney disease Fibrosis Arteriohyalinosis Solid organ transplantation (SOT) has rapidly evolved since the 1960s as the primary treatment for patients with advanced and end-stage renal, liver, heart, and lung diseases [ 1, 2 ]. Early...

...Jing Liu; Tan Deng; Yaxin Wang; Mengmeng Zhang; Guannan Zhu; Haiming Fang; Jiajia Wang Background: Intestinal fibrosis is the major complication of Crohn’s disease (CD). There are no other good treatments for CD except surgery and remains a refractory disease. Calycosin (CA), the active component...

...Ju-Yong Song; Do Vinh Truong; Beom-Seok Yang Aim: Previous studies have suggested that quercetin is effective for treating diverse chronic disorders including organ fibrosis and airway and cardiovascular disorders. To access the pharmacological background for its broad efficacy, we examined...

.... Alanine aminotransferase (ALT) and γ-glutamyl transpeptidase (γ-GTP) serum activities, glycogen content, reduced/oxidised glutathione (GSH/GSSG) ratio, lipid peroxidation degree and fibrosis (using hydroxyproline content and a histopathological analysis) were measured. Results: CCl 4 increased...

... responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Fibrosis Transforming growth factor-β Smad proteins Cyclosporin Original Paper Pharmacology 2013;91:20 28 DOI: 10.1159/000343764 Received...

...Alfonso Leija Salas; Tania Díaz Montezuma; German Garrido Fariña; Jorge Reyes-Esparza; Lourdes Rodríguez-Fragoso Aim: To evaluate the effect of genistein on the fibrosis and matrix degradation caused by experimentally induced fibrosis in rats. Methods: Hepatic fibrosis was brought about by chronic...

... Amlodipine Pranidipine Autoimmune myocarditis Heart failure Tumor necrosis factor-α Inducible nitric oxide synthase Fibrosis Sarcoplasmic reticulum Ca 2+ ATPase2 Original Paper Pharmacology 2006;77:1 10 DOI: 10.1159/000091746 Received: July 4, 2005 Accepted after revision: January 12, 2006...

... manner. Central venous pressure and left ventricular end-diastolic pressure were lower, and ±dP/dt and fractional shortening were higher in group H than group V. Eplerenone also attenuated myocardial fibrosis and reduced left ventricular mRNA expressions of TGF-β 1 and collagen-III. Our results indicate...

... Neurociencias, CINVESTAV, México, y cFacultad de Farmacia, Universidad Auto´ noma del Estado de Morelos, Morelos, México Key Words Hepatic stellate cells W Collagen W Fibrosis W Transforming growth factor-ß1 W Urokinase-type plasminogen activator Abstract The aim of this study was to determine whether...

... heart weight, heart weight to body weight ratio, myocardial fibrosis, central venous pressure and left ventricular end-diastolic pressure than low-dose pranidipine (group 0.03) and group V. Pranidipine at high dose also decreased the left ventricular systolic and diastolic dimensions, and increased...