...Youli Tao; Hua Zhou; Lili Huang; Xiaoyin Xu; Yun Huang; Lili Ma; Lingna Li; Xu Yao; Ronghui Zhang; Yuyu Zhang; Weibo Rong; Chaojun Yang; Taotao Yang; Yi Shen; Rixiang Wang Introduction: Although oxidative stress has been demonstrated to mediate acute ethanol-induced changes in autophagy...

...Reiko Akagi; Michiko Ohno; Kiminori Matsubara; Mitsuaki Fujimoto; Akira Nakai; Sachiye Inouye In this study, we investigated the protective effect of glutamine on barrier dysfunction induced by ethanol, by using human epithelial colorectal adenocarcinoma cells (Caco-2). Our results show...

... against the ethanol-induced gastric damage in rats. Methods: The rats were divided into eight groups composed of a non-ethanol group, only EIQ (10 mg/kg) group, groups with absolute ethanol after pretreatment with various doses of EIQ (1, 3 and 10 mg/kg), rebamipide (10 mg/kg), stillen (40 mg/kg...

...Ravi K. Sajja; Chandradhar Dwivedi; Shafiqur Rahman The aim of the present study was to examine the effects of two neuronal nicotinic acetylcholine receptor ligands on acute ethanol-induced dopamine (DA) function in the C57BL/6J mouse ventral striatumusing an ex vivo assay and high-performance...

... secretion under general anesthesia, and (b) study of the gastric mucosal resistance against the damage induced by ethanol and indomethacin in conscious rats. Basal acid secretion and the acid response to pentagastrin or to histamine were similar in rats assuming ordinary drinking water or thermal water...

...P.T.-H. Wong; C.H. Tan; M.F. Kwan; L.K. Ang; W.L. Teo [ 3 H]PK 11195 binding to the peripheral benzodiazepine binding site was investigated in the brain and liver of mice treated with ethanol (4 g/kg, p.o.) daily for 5 days. In the brain stem, B max was decreased by 78% in the ethanol-treated group...

..., gastric acid secretion was also reduced, but not to the extent of SHR. The GMBF was increased instead. Adenosine potentiated ethanol-induced mucosal damage in SHR, which was likely caused by GMBF reduction. It is concluded that adenosine produces a greater depressive action on the stomach in SHR...

...Masahiko Saito; Gregory A. Broderick; Joseph A. Hypolite; Robert M. Levin Pharmacologic and behavioral effects of alcohol on male sexual activity have long been controversial. Among the varied effects of alcohol, it has been described that ethanol reduces nitric oxide production. Appreciating...

...Rashid M. Khan; Magdi R.I. Soliman The present study was conducted to evaluate and compare effects of the benzodiazepine agonist diazepam, antagonist flumazenil and inverse agonist RO 15-4513 on ethanol-induced changes in β-endorphin (β-EN) levels in specific rat brain regions. Male Sprague-Dawley...

... output. 5-HT time dependently reduced GMBF and pepsin secretion, but not that of acid and Na + . These actions were not altered by ondansetron pretreatment. The drug, however, dose dependently reduced ethanol-induced gastric mucosal lesions in the 5-HT-treated animals. These findings indicate that 5-HT 3...

...-3696, nitrazepam or zopiclone alone and in combination with a ‘social’ dose of ethanol on mouse hippocampal EEG. Ro 41-3696 (1–10 mg/kg), nitrazepam (0.1 and 1 mg/kg), and zopiclone (1 and 10 mg/kg) each alone caused an increase in the drowsy EEG pattern associated with a decrease in the duration...

...X.G. Liu; C.H. Cho; J.K.S. Ko Calcium channel blockers like verapamil have been shown to potentiate ethanol-induced gastric mucosal damage. However, the exact mechanism for this adverse drug interaction is still unknown. We used felodipine to study the ulcerogenic mechanisms of calcium channel...

...Artensie Carter; Magdi R.I. Soliman The present investigation was conducted to evaluate the effects of estradiol on ethanol-induced alterations of β-endorphin (β-EN) and met-enkephalin (ME) levels in specific brain regions of ovariectomized rats. Female Sprague-Dawley rats (100-124 g) adapted...

... transplants. This study evaluates the changes in the MEGX formation test associated with changes in liver mass and ethanol pretreatment in a rat model. Mean MEGX levels were significantly higher for the sham-operated group versus each of the partially hepatectomized groups at 15, 30, and 45 min after...

..., instructions or products referred to in the content or advertisements. Ethanol Ethoxyresorufin N-Nitrosodimethylamine p-Nitrophenol Cytochrome P450IIE1 Liver Lung 24 04 1991 15 07 1991 6 6 2008 Original Paper Pharmacology 1992;44:117-123 Gary P. Carlson Brian J. Day...

...C.H. Cho; C.W. Ogle The role of the cholinergic nervous system in ethanol-induced gastric mucosal damage has been examined in rats. Oral administration of 50 or 80% ethanol produced haemorrhagic lesions which were reduced by atropine pretreatment (0.65, 2.5, 5 or 10 mg/kg injected i.p...

... determined in the liver. Ethanol did not markedly induce these enzymes in either tissue. Glucuronidation and sulfation of 1-naphthol and 7-hydroxycoumarin were also studied in the isolated perfused rabbit lung as an intact cell model. Neither glucuronidation nor sulfation of 1-naphthol was observed...

...Ebenezer T. Oriaku; Karam F.A. Soliman Male Sprague-Dawley rats weighing between 180 and 220 g and maintained under controlled lighting and temperature conditions were used in this experiment. Animals were given ethanol (3 g/kg, p.o.) 24 h after fasting. One group was given ethanol at 10.00 h...

...Lester A. Reinke; Joel S. Tupper; David J. Sweeny Rates of 7-ethoxycoumarin (7EC) O-deethylation in perfused livers were increased approximately 3-fold by chronic ethanol feeding. The acute addition of ethanol (5 m M ) and antimycin A (0.03 m M ) strongly inhibited 7EC metabolism in perfused livers...

...Barbara Malinowska; Dariusz Pawlak; Ewa Chabielska; Włodzimierz Buczko In pithed rats, the intravenous administration of serotonin (3, 10, 30, 100, 300 and 1,000 µg/kg) produced a dose-dependent increase in blood pressure. This action of 5-HT was not changed by chronic ethanol intoxication (6.0 g...