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Keywords: Endothelium
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Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2017) 100 (3-4): 188–193.
Published Online: 14 July 2017
...-deficient ( Gper -/- ) mice (4 and 24 months old). In wild-type mice, aging markedly impaired endothelium-dependent, nitric oxide (NO)-mediated relaxations to acetylcholine, which were largely preserved in renal arteries of aged Gper -/- mice. The Nox inhibitor gp91ds-tat abolished this difference...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2017) 99 (5-6): 275–280.
Published Online: 02 March 2017
...Masashi Tawa; Takashi Shimosato; Hiroshi Sakonjo; Tomio Okamura Background/Aims: Nitroglycerin is widely used as a coronary vasodilator in the treatment of ischemic heart diseases. This study investigated the influence of hypoxia on nitroglycerin-induced relaxation in endothelium-intact...
Journal Articles
Pharmacology (2016) 98 (5-6): 272–278.
Published Online: 27 August 2016
...Abha Sahni; Erica D. Thomasson; Riya Shah; Sanjeev K. Sahni Cellular oxidative stress in the endothelium of blood vessels leads to several pathophysiological sequelae, including vascular damage and dysfunction, inflammation and atherosclerosis. Heme oxygenase-1 (HO-1) provides protection against...
Journal Articles
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2014) 94 (3-4): 157–162.
Published Online: 03 October 2014
... the role of the endothelium-derived relaxing factors on the vascular effects of organophosphates. This study was carried out to evaluate the vascular effects of malathion and the role of nitric oxide (NO) and prostacyclin (PGI 2 ). Methods: Vascular reactivity measuring isometric forces in vitro (‘organ...
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2011) 88 (1-2): 72–81.
Published Online: 16 August 2011
... and long-term actions of these drugs on mesenteric resistance arteries of the SHR. Incubation with pioglitazone or rosiglitazone (10 –5 mol/l) improved endothelium-dependent relaxations to acetylcholine and the endothelial modulation of phenylephrine contractions. Acetylcholine relaxations that were...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1994) 49 (1): 11–22.
Published Online: 10 June 2008
... current which is permeable to calcium was identified in cell-attached patches in cultured human umbilical vein endothelial cells. ET-1 (1 nmol/l) increased activity of the nonspecific cation channel. ET-1 may increase calcium influx into endothelial cells and promote synthase and release of endothelium...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1994) 48 (6): 374–379.
Published Online: 10 June 2008
..., instructions or products referred to in the content or advertisements. Nitric oxide synthase Digitonin Lysophosphatidylcholine Endothelium L-Arginine L-Citrulline Original Paper Pharmacology 1994;48:374-379 R. Dudek A. Conforto V. Pinto R.J. Bing Department of Experimental Cardiology, Huntington...
Journal Articles
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1995) 50 (4): 247–256.
Published Online: 10 June 2008
..., a novel vasodilator which also releases endothelium-derived relaxing factors, activated the outward calcium-dependent potassium conductance. PMA and PDBu, but not PMM, reduced the outward conductance induced by cyclopiazonic acid and LP-805. These effects of PMA and PDBu on potassium currents may...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1995) 50 (4): 238–246.
Published Online: 10 June 2008
...); relaxation of aortic rings to the endothelium-independent vasodilator nitroglycer-in was similar; (ii) more pronounced maximal 5-hydroxy-tryptamine-induced-contractions in the presence of L-NAME, and (iii) a more pronounced reduction in phenylephrine-induced contractions by verapamil. These results...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1991) 42 (5): 246–251.
Published Online: 06 June 2008
...Florence Bernard; Simone Jouquey; Gilles Hamon The vascular relaxant effect of salbutamol and its dependence on the endothelium were studied in the isolated dog coronary artery, precontracted with prostaglandin F 2α . Salbutamol induced a concentration-dependent relaxation which was partially...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1992) 44 (6): 324–333.
Published Online: 06 June 2008
... muscarinic binding sites which possess many but not all of the properties associated with classical muscarinic receptors. Muscarinic receptors Endothelium Cultured endothelial cells 5 09 1991 4 10 1991 6 6 2008 © 1992 S. Karger AG, Basel 1992 Copyright / Drug Dosage...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1989) 39 (6): 373–382.
Published Online: 05 June 2008
..., ouabain, B-HT 920, Bay K 8644, phorbol-12-myristate-13-acetate and arachidonic acid. Bay K 8644 also enhanced the contractile response to noradrenaline. The amplification was not substantially altered by removing the endothelium of the aorta. The increase in cytosolic calcium availability induced...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1990) 41 (3): 141–148.
Published Online: 05 June 2008
...J. Pataricza; T. Binder; N. Menon; R.J. Bing Experiments were conducted in a superfusion bioassay system in which the effluent of a bovine main pulmonary artery (generator) was allowed to superfuse a spirally cut precontracted bovine arterial strip (detector), which had been deprived of endothelium...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1990) 41 (1): 24–35.
Published Online: 05 June 2008
... strain of rats. In 12 mmol/l KCl, the maximal contractile response to Bay K 8644 was increased in both SHRSP (71%) and WKY rats (25%). In 18 mmol/l KCl, maximal contractile responses to Bay K 8644 in the two strains were similar (SHRSP = 73%, WKY = 76%). Removal of the endothelium did not significantly...