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Keywords: Endothelin-1
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Subject Area:
Pharmacology
Pharmacology (1996) 53 (4): 234–240.
Published Online: 10 June 2008
... inhibitor. On the contrary, these rhythm disturbances were potentiated by big endothelin-1 in isolated perfused whole hearts from guinea pigs. Endothelin-1 when infused through the coronary circulation at a concentration of 10 –10 mol/l, produced an increase in coronary perfusion pressure without altering...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1997) 54 (6): 328–332.
Published Online: 10 June 2008
...Sadi S. Özdem; Çağlar Öğütman Cadmium administered intraperitoneally at a dose of 1 mg/kg/day for 15 days caused a significant increase in mean arterial blood pressure. Endothelin-1 and noradrenaline produced concentration-dependent contractions of aortic rings that attained a lower maximal...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1993) 47 (5): 277–285.
Published Online: 10 June 2008
...Andrew C.G. Uprichard; Liguo Chi; Benedict R. Lucchesi The role of neutrophils in the conversion of big endothelin (Big-ET) to endothelin-1 (ET-1) was assessed in two models. In rabbit isolated hearts, ET-1 demonstrated significant increases in coronary perfusion pressure (PP) at doses greater than...
Journal Articles
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2006) 76 (4): 163–169.
Published Online: 13 April 2006
... incorporation and endothelin-1 secretion were examined. Isosteviol (1–100 µmol/l) inhibits angiotensin-II-induced DNA synthesis and endothelin-1 secretion. Measurements of 2′7′-dichlorofluorescin diacetate, a redox-sensitive fluorescent dye, showed an isosteviol-mediated inhibition of intracellular reactive...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2003) 68 (3): 131–139.
Published Online: 06 June 2003
...Glaucia Elena Callera; Lusiane Maria Bendhack We assessed the functional response and the mechanisms following receptor stimulation of endothelin-1 (ET-1) in the rat renal artery. In this study, isometric tension was recorded in renal artery rings without endothelium. Cumulative application of ET-1...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1998) 56 (4): 207–215.
Published Online: 11 March 1998
...T. Utkan; Y. Sarioglu; S. Yildirim It is known that diabetes mellitus alters the vascular responsiveness to several vasoconstrictors and vasodilators. Endothelium-derived nitric oxide is a potent endogenous nitrovasodilator, and endothelin-1 (ET-1) is a potent endothelium-derived vasoconstrictor...