... metabolism CYP2C19 polymorphism Allelic variants The cytochrome P450 (CYP450) group constitutes one of the most important groups of drug-metabolizing enzymes in the liver. Among these CYP enzymes, hepatic CYP isoforms CYP2C9, CYP2C19, CYP2D6, and CYP3A4 have been proved to play a critical role...

... that typically contain multiple copies of a gene that results in an increase in drug metabolism; extensive metabolizers that have at least one single wild-type copy of the gene; intermediate metabolizers (IMs) that exhibit decreased enzymatic activity and carry two reduced function alleles or one deficient...

.... CYP2C9 Allelic variants Drug metabolism Substrate inhibition Mestranol Mestranol [(17β)-17-ethynyl-3-methoxyestra-1,3,5 (10)-trien-17-ol] is a well-known pharmaceutical estrogen that is widely used in oral contraceptives combined with progestin [ 1 ]. In infertility experiments, researchers...

... advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Danthron Drug metabolism Rat Biliary...

.... Brewerb Effects of Plasmodium berghei Infection on Arteether Metabolism and Disposition a Department of Pharmacology, Walter Reed Army Institute of Research. Washington. D.C., USA and b Armed Forces Research Institute of Medical Science, Bangkok, Thailand Key Words Drug metabolism Antimalarials Malaria...

... to in the content or advertisements. Morphine Immunomodulation Drug abuse Drug metabolism Cell-mediated immunity Original Paper Pharmacology 1995;50:51-62 Peter T. Thomasa Hemendra N. Bhargavab Robert V. Housea Life Sciences Department, IIT Research Institute, and Department of Pharmaceutics...

..., instructions or products referred to in the content or advertisements. Omeprazole Drug metabolism Steroid hormone metabolism Cytochrome P450 Pharmacology 1991;42:322-326 Omeprazole and Cytochrome P450-Dependent Hepatic Metabolism: A Comparison of Endogenous and Exogenous Substrates in Male Rats...

... Hepatocytes Drug metabolism Antipyrine Lidocaine Propranolol SKF 525A Pharmacology 36: 279-282 (1988) © 1988 S. Karger AG. Basel 0031-7012/88/0364-027975/0 Effect of Inflammation on the Metabolism of Antipyrine, Lidocaine and Propranolol in Isolated Rat Hepatocytes B. Chindavijak, F.M. Belpaire, M.G...

... 6 11 1989 5 6 2008 Cigarette smoking Drug metabolism Oxidation Conjugation Antipyrine Acetaminophen Pharmacology 1990;40:77-84 © 1990 S. Karger AG. Basel 0 0 3 1- 7 0 1 2/90/0402-0077S2.75/0 Differential Effect of Cigarette Smoking on Antipyrine Oxidation versus Acetaminophen...

... David J. Greenblatt, Marcia K. Divoll. Jerold S. Harmalz, Richard /. Shader Division of Clinical Pharmacology, Departments of Psychiatry and Medicine, Tufts University School of Medicine and New England Medical Center, Boston, Mass., USA Key Words. Antipyrine Pharmacokinetics Drug metabolism Drug...

... were confirmed by subjecting the pulmonary cytochromes to gel electrophoresis, and staining of the gels for protein and heme. Phenobarbital Pulmonary cytochromes P-450 Monooxygenase induction Drug metabolism 14 08 1984 24 09 1984 4 6 2008 © 1985 S. Karger AG, Basel 1985...

... was substantially enhanced in SHR rats with only slight increases in cytochrome P-450 content and aniline hydroxylase activity compared to WKY rats. The substrate-specific increases in the microsomal drug metabolism in SHR rats were accompanied by an increase in the prominence of a protein with molecular weight...

... simply and noninvasively as a probe of hepatic mixed function oxygenase activity in humans. 24 04 1984 5 06 1984 4 6 2008 Phenytoin Saliva Single sample Probe Drug metabolism Clearance Pharmacology 30: 145-152 (1985) © 1985 S. Karger AG. Basel 0031-7012/85/0303-0145 $2.75/0...

... treatment caused an enhancement of microsomal drug metabolizing enzymes catalyzed N-demethylations of diphenhydramine, pethidine, morphine and aromatic hydroxylation of aniline. A single oral dose of methaqualone (60 mg/kg) did not result in any significant change in the activities of drug metabolizing...

... for drug substrate by the microsomal enzymes. These in vitro studies show that hepatic metabolic elimination of both propranolol and verapamil is decreased by hypothermia. Pharmacology 20: 95 100 (1980) Effect of Hypothermia on Drug Metabolism In vitro Studies with Propranolol and Verapamil R .G...

... to in the content or advertisements. Anticoagulant drugs Enantiomers of phenprocoumon Drug metabolism Pharmacokinetics Drug interaction Original Papers Pharmacology 21: 313-322 (1980) Effect of Induction and Inhibition of Drug Metabolism on Pharmacokinetics and Anticoagulant Activity of the Enantiomers...

... pattern of impaired drug metabolism in vitamin A deficiency, glutathione S-aryltransferase activity was markedly enhanced at all time points from 4 to 10 weeks. Activities of this enzyme were twice controls at 6 weeks, a time at which no other enzyme changes were observed. © 1980 S. Karger AG, Basel...

.... Glutathione S-transferase Human tissues Fetal tissues Drug metabolism Pharmacology 22: 322-329 (1981) Glutathione S-Transferase Activity in Human Fetal and Adult Tissues Hasan Mukhtara, Clema E M. Zoetemelka. Aalbert J. Baarsa, Juul Th. Wijnen b, Lucie M.M. Blankenstein- Wijnenb, P. Meera Khanb. Douwe D...

... Debrisoquine hydroxylation Cross-over study Drug metabolism Pharmacogenetics Human volunteers Pharmacology 22: 349-358 (1981) Influence of the Genetically Controlled Deficiency in Debrisoquine Hydroxylation on Antipyrine Metabolite Formation M. Danhof\ ldtch. M.W.E. Teunissena. T.P. Sloanb, D.D...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Drug metabolism Hepatic clearance Liver circulation Liver cirrhosis...