... (NO) release, is evolutionarily conserved throughout animals and humans. Moreover, dopamine is a key precursor for morphine biosynthesis. Method: The present study evaluated a series of preclinical experiments to evaluate the effects of low-level morphine treatment upon neuro-immune tissues exposed to rotenone...

... anticancer therapeutics do not readily penetrate into the brain due to the tight control at the cerebrovascular barrier. Numerous studies have suggested that dopamine D 2 receptor (D 2 R) antagonists, such as first generation antipsychotics, may have anticancer efficacy in vivo and in vitro. The role...

...Mohammad Raziya Banu; Muhammed Ibrahim; K. Prabhu; Srinivasagam Rajasankar Withaferin A (WA) was evaluated for its neuro-protective efficacy on ageing induced striatal dopamine (DA) and behavioural changes in aged rats. Wistar albino rats were divided into group I – young (3 months), Group II...

... of locomotor activity. STAT6-deficient mice exhibited a significantly enhancing dopamine and 5-hydroxytryptamine (5-HT, serotonin) in brain. In addition, the expression of serotonin transporter in the hippocampus was markedly downregulated in STAT6-deficient mice. These results provide the first evidence...

... concentration in mice. Intracerebroventricular administration of rimonabant caused increases in blood glucose and gastrointestinal transit, suggesting a central nervous system site of action. Increases in blood glucose by rimonabant were partially blocked by the dopamine receptor antagonist haloperidol...

..., and increased serotonin and dopamine levels in the brain tissues. A subeffective dose (50 mg/kg) of these formulations enhanced the antidepressant-like effect of classical antidepressants with varied mechanisms of action. In addition, an SJW dose of 25 mg/kg showed a significant antidepressant-like effect...

...Ravi K. Sajja; Chandradhar Dwivedi; Shafiqur Rahman The aim of the present study was to examine the effects of two neuronal nicotinic acetylcholine receptor ligands on acute ethanol-induced dopamine (DA) function in the C57BL/6J mouse ventral striatumusing an ex vivo assay and high-performance...

...Alexia E. Pollack; Kroum D. Dimitrov; Jonathan D. Drake Background/Aims: In unilaterally dopamine-depleted rats, repeated treatment with dopamine agonists sensitizes contralateral rotational behavior. Since A2a adenosine receptors are co-localized with D2 dopamine receptors in the brain...

...A. Meneguz; P. Betto; G. Ricciarello The effects of short-term intravenous administration of harmine, a monoamine oxidase inhibitor, on the plasma concentrations of L-Dopa and on dopamine levels in the brain striata of rats and rabbits after L-Dopa administration were studied. Harmine affects the L...

...Fu Y. Chueh; Mng T. Hsieh; Chieh F. Chen; Mao T. Lin The effects of DL-tetrahydropalmatine (THP; a main active substance of the Chinese herb corydalis), haloperidol (a dopamine D 2 receptor antagonist), apomorphine and amphetamine on cardiovascular function and striatal dopamine (DA) release were...

... by using a salicylate trapping method. The amount of hydroxyl radicals formed peaked at 20 min after reperfusion (approximately 150% vs. basal level). The dopamine level markedly increased shortly after the initiation of an ischemic insult and thereafter waned. By contrast, the concentration of 3,4...

...Tomio Okamura; Shoichiro Ide; Noboru Toda DQ2511, a possible antiulcer agent, relaxed dog, monkey and human arterial strips from various organs; the effect was most evident in the gastroepiploic artery. The relaxation was not influenced by timolol, atropine, dopamine receptor antagonists, and K...

...Ralph Dawson, Jr.; Rhonda Felheim; Son Nguyen The effects of sodium nitroprusside (SNP) on dopamine synthesis in a porcine renal epithelial cell line (LLC-PK 1 ) were evaluated. Subsequent studies examined the actions of the degradation products of SNP (cyanide, ferrous ion and nitric oxide...

...Bahjat A. Faraj; Zbigniew L. Olkowski; Richard T. Jackson The main objective of the present investigation was to determine whether the uptake of [ 3 H]-dopamine in human lymphocytes is mediated through a serotonin transporter. This was examined by studying the effects of various monoamine uptake...

...Suleiman I. Sharif The contractile effect of dopamine in the rat isolated seminal vesicle was investigated to determine the nature of the receptors involved. Noradrenaline (NA; 10 –8 to 10 –4 mol/l), phenylephrine (PE; 10 –7 to 10 –4 mol/l > and dopamine (DA; 10 –5 to 10 –2 mol/l) produced...

...D.D. Wheeler; B.M. Chapman; J.G. Ondo Following preloading of striatal synaptosomes with 3 H-dopamine (DA), the kinetics of release have been followed for a 60-min incubation period. DA appears to be totally releasable under both depolarizing (veratridine) and nondepolarizing conditions. Cocaine...

...David P. Brooks; Dennis DePalma The effect of the dopamine DA-1 receptor agonist fenoldopam on amino-acid-induced glomerular hyperemia and hyperfiltration was evaluated in conscious chronically instrumented dogs. Infusion of either amino acids (L-alanine, 4.1 mg/kg·min; L-proline, 3.2 mg/kg·min; L...

...Kouichi Kurata; Ryoko Shibata The differential effects of haloperidol on dopamine release and its metabolism were investigated in the anteromedial frontal cortex and the caudate putamen using the intracerebral dialysis method in anesthetized rats after single intraperitoneal injections of 0.01...

...Bahjat A. Faraj; Zbigniew L. Olkowski; Richard T. Jackson Freshly isolated human lymphocytes from 11 healthy subjects had specific binding sites for dopamine which were dependent on time, temperature and sodium, and appeared to follow Michaelis-Menten kinetics. The apparent affinity constant (K D...

...G.Y. Kao; M.A. Elchisak Dopamine sulfate (DAS) is formed by the action of phenolsulfotransferase (PST) on dopamine (DA). Since probenecid is often used to investigate the transport of monoamine acidic metabolites such as DAS from the brain, we investigated the effect of probenecid on rat brain PST...