..., pregnenolone acetate, deoxycorticosterone acetate, tamoxifen and SKF 525-A exerted markedly different concentration-dependent inhibitions of intestinal and liver AHH activities. The most potent inhibitors of AHH activity were captan, BHA, chlorpromazine, thioridazine, disulfiram and menadione. The ability...

...Anthony A. Fossa; Gary P. Carlson Disulfiram has been shown to decrease the incidence of arrhythmias in rabbits exposed to trichloroethylene. In this study additional cardiotoxic models were used to evaluate disulfiram’s antiarrhythmogenicity. Disulfiram (7.5 mg/kg, i.v.) significantly decreased...

...M. Milandri; H.E. Poulsen; L. Ranek; P.B. Andreasen No hepatotoxicity was demonstrated after 90 days in rats treated with two dose levels of disulfiram. A reversible inhibition of microsomal p-nitroanisole demethylase activity was found. In phenobarbital-treated rats disulfiram 100 mg/kg did...

...Elliot S. Vesell; Thomas Passananti; Patricia A. Glenwright Disulfiram inhibited antipyrine metabolism reproducibly in three experiments utilizing three different groups of normal human volunteers. In these experiments disulfiram in a dose of 3.5 mg/kg body weight was given orally twice daily for 4...

...M. Hemmati; A. Rezvani; B. Djahanguiri Aspirin at the dose of 200 mg/kg, administered orally, produced gastric mucosal ulceration in 100% of rats after 4 h. Pretreatment of animals with α-methyldopa at the doses of 25 and 50 mg/kg and/or disulfiram at the doses of 100, 200 and 400 mg/kg...

...D. Winter; S. Sauvard; C. Stǎnescu; M. Theodorescu; J. Winter; I. Nitelea 20 08 1968 27 5 2008 Pharmacology 2: 27-31 (1969) Ethanol toxicity Ethanol narcosis Disulfiram Lipotropic effect of Metronidazol Protection with Metronidazol The Influence of M etronidazol and Disulfiram...

... liver slices, isovanillin was rapidly converted to isovanillic acid, whereas the conversion was very slow in cryopreserved liver slices due to low aldehyde dehydrogenase activity. The formation of isovanillic acid was not altered by allopurinol, but considerably inhibited by disulfiram. It is therefore...