...Nejia Tounsi; Imen Trabelsi; Emna Kerkeni; Mohamed Habib Grissa; Nizar Fredj; Adel Sekma; Malek Mzali; Ilhem Hellara; Kamel Monastiri; Wahiba Douki; Semir Nouira Background: Digoxin is a substrate of P-glycoprotein (P-gp) and organic anion transporting polypeptide transporters that are encoded...

...Ping Xu; Zhi-Ping Jiang; Bi-Kui Zhang; Ji-Ying Tu; Huan-De Li Objective: To investigate the effect of single-nucleotide polymorphisms (SNPs) and the haplotypes of MDR1 on the pharmacokinetics of single-dose digoxin in healthy Chinese volunteers. Methods: After the genotypes of the MDR1 alleles...

...Sevm Ercan; Mustafa Ilhan; Mehtap Kilinç; Kazim Türker The arrhythmogenic actions of endothelin peptides were studied in isolated perfused hearts from guinea pigs and rats. Digoxin-induced ectopic ventricular complexes were partially antagonized by phosphoramidon, an endothelin-converting enzyme...

...Pierre Schulz; Terrence F. Blaschke Indogs, a single dose of quinine led to a redistribution of digoxin in tissues, which was reflected by an acute and biphasic change in plasma and blood concentrations. 6 04 1983 24 10 1983 4 6 2008 © 1984 S. Karger AG, Basel 1984...

...Jonathan D. Geiger; Gopal Das; Surendra S. Parmar The clinically relevant interaction between quinidine (3 mg/kg) and digoxin (0.6 mg/kg plus 20 μCi 3 H-digoxin) was investigated using unanesthetized and unrestrained guinea pigs for in vivo pharmacokinetic and tissue disposition studies. Quinidine...

...Wolfgang Meister; Neal L. Benowitz; Leslie Z. Benet In 6 patients with severe left-sided cardiac failure the absorption of drug from digoxin tablets was assessed by simultaneous administration of a commercially available tablet and of an intravenous tracer dose before and during therapy. Lag time...

...D.J. Weidler; N.S. Jallad; D.B. Keener; S.K Das; J.G. Wagner 24 h after ligation of the left middle cerebral artery in cats (sham operation in the control group), a constant intravenous infusion of digoxin was begun and continued to toxicity (ventricular rhythm) and death. We found that the lethal...

...Hermann R. Ochs; David J. Greenblatt; Jerold S. Harmatz; Gunther Bodem The relation of serum digoxin concentrations (SDC) to subjective manifestations of toxicity was evaluated in 300 patients with permanent transvenous pacemakers. All had been receiving the same daily dose of a glycoside...

...Bruce H. Kroening; Michael Weintraub The influence of age on tissue distribution of digoxin in mice and guinea pigs and uptake by mouse heart slices was investigated. 4 h after a single dose of 3 H-digoxin, tissue:plasma ratios were significantly greater in very young animals and declined...

...B. Beermann; K. Hellström Tritium labelled digitoxin and digoxin were administered intragastrically to rats provided with thoracic lymph duct fistulas. Approximately 4% of the label was recovered in the lymph collected during 48 h. It was concluded that lymph duct drainage is ineffective...

...David J. Greenblatt; David W. Duhme; Jan Koch-Weser; Thomas W. Smith Eight healthy males received 0.75 mg of digoxin by ten modes of administration in a single-dose multicrossover bioavailability study. Digoxin concentrations in multiple blood samples drawn after each dose and in six consecutive 24...

...Laurent Salphati; Leslie Z. Benet Digoxin, a cardiac glycoside, is a substrate of the multidrug transporter P-glycoprotein (Pgp), and in rats has also been identified as a substrate for cytochrome P 450 3A (CYP3A). Ketoconazole, an antifungal agent, was shown to inhibit Pgp in a multidrug-resistant...