... the proteasome activity. Methods: Cardiomyopathy was induced in streptozotocin-treated diabetes mellitus (DM) and db/db mice. Luteolin (20 mg kg −1 ·day −1 ) was administrated via gavage for 12 weeks. In vitro , high glucose and high insulin (HGI, glucose at 25.5 mM and insulin at 0.1 µM) inducing primary...

...Mohamed Elsayed Kelany; Tahir M. Hakami; Adel H. Omar; Mohamed A. Abdallah Aims: The present study evaluated the effects of sitagliptin-insulin against type 2 diabetes mellitus with neuropathy in rats and possible neuroprotective mechanisms. Methods: Diabetes was induced in 32 adult male albino...

...Harumi Okuyama; Peter H. Langsjoen; Naoki Ohara; Yoko Hashimoto; Tomohito Hamazaki; Satoshi Yoshida; Tetsuyuki Kobayashi; Alena M. Langsjoen Background: Positive associations have been observed between cardiovascular disease (CVD) and type 2 diabetes mellitus (DM), but their causal relationship has...

...Azza M. Baraka; Maha M. Deif Background: The potential utility of 5′-adenosine monophosphate-activated protein kinase (AMPK)-activating agents, such as metformin, in inducing angiogenesis, could be a promising approach to promote healing of gastric ulcers complicated by diabetes mellitus. The aim...

... and cUrology, Dokuz Eylul University, Medical Faculty, Izmir, Turkey Key Words Diabetes mellitus Corpus cavernosum, human Rho-kinase Serotonin Abstract Background/Aims: Serotonin (5-hydroxytryptamine, 5-HT)- induced contraction and the involvement of RhoA/Rho-ki- nase pathway in the 5-HT-induced...

.... Collectively, these results suggest that Zopolrestat exerts a protective effect on the slowly developing diabetic cataract, as well as reducing albuminuria and proteinuria. Albumin Aldose reductase inhibitors Cataract Diabetes mellitus Kidney Na-K-ATPase Proteinuria Zopolrestat 9 11 1995...

..., instructions or products referred to in the content or advertisements. Antihyperglycemic drug Antihyperlipidemic drug Diabetes mellitus Hydrochlorothiazide Metformin Plasma glucose Plasma lipids Pyrazinoylguanidine Pharmacology Original Paper Pharmacology 1996;52:145-152 Yousifl. A-Rahim Karl H...

.... Antihyperglycemic drug Antihyperlipidemic drug Diabetes mellitus Hydrochlorothiazide Metformin Plasma glucose Plasma lipids Pyrazinoylguanidine Pharmacology Original Paper Pharmacology 1996;52:135-144 Yousifl. A-Rahim Karl H. Beyer, Jr. ElliotS. Vesell Department of Pharmacology, Pennsylvania State...

... Indomethacin Nitric oxide Diabetes mellitus Pharmacology Original Paper Pharmacology 1996;53:151-159 Hassan El-Kashef Department of Pharmacology, Faculty of Pharmacy, Mansoura University, Mansoura, Egypt Hyperglycemia Increased the Responsiveness of Isolated Rabbit's Pulmonary Arterial Rings to Serotonin...

... concentrations was unaffected by adenosine deaminase or pertussis toxin, suggesting that PZG did not activate G i , the inhibitory guanyl nucleotide regulatory protein. Pyrazinoylguanidine Cyclic AMP Diabetes mellitus Lipolysis Adipocytes © 1996 S. Karger AG, Basel 1996 Copyright / Drug Dosage...

... on gluconeogenesis and cyclic AMP in perfused rat liver where PZG decreased gluconeogenesis and cyclic AMP concentrations. Pyrazinoylguanidine Cyclic AMP Diabetes mellitus Phosphodiesterase Gluconeogenesis © 1996 S. Karger AG, Basel 1996 Copyright / Drug Dosage / Disclaimer Copyright: All rights...

.... Pyrazinoylguanidine STZ rats Cataracts Diabetes mellitus Eye Pharmacology Original Paper Pharmacology 1997;54:256-260 Received: D ecem bers 1996 Accepted: February 3,1997 Markh . Foiiansbee Karl H. Beyer, Jr.* Elliot S Vesell Studies on Pyrazinoylguanidine 6. Prevention of Cataracts in STZ-Diabetic Rats...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Nitric oxide Streptozotocin Insulin Diabetes mellitus 27 05...

... and glutamic pyruvic transaminase activity observed when either drug was given alone. These results suggest that administration of thiazide diuretics to treat edema encountered during anti-inflammatory steroid therapy may increase the risk of diabetes mellitus, atherosclerosis and certain thrombotic disorders...

..., instructions or products referred to in the content or advertisements. α-Glucosidase inhibition Deoxynojirimycin derivatives Miglitol Digestion Diabetes mellitus Carbohydrate malabsorption Pharmacology 1991;43:318-328 © 1991 S. Karger AG, Basel 0031-7 0 12/91/0436-0318S2.75/0 Inhibition...

...A. Beyer-Mears; F.T. Murray; E. Cruz; J. Rountree; M. Sciadini Diabetic nephropathy leading to kidney failure is a major complication of type I (insulin-dependent) diabetes mellitus and is associated with progressive proteinuria. In the present 6-month study, effects of two structurally dissimilar...

...Jin Qi; Robert M. Curley; John A. Belis The effect of diabetes mellitus on intracellular calcium concentration was measured in single rat bladder smooth muscle cells using the fluorescent calcium indicator dye fura-2 AM. Techniques were developed for isolation and short-term culture of rat bladder...

...Soosaiah Gunasekaran; Judith A. Young; Thomas E. Tenner, Jr. The present study was undertaken to compare the cardiomyopathies induced by experimental diabetes mellitus and chronic isoproterenol (ISO) pretreatment on inotropic reactivity of right ventricular strips from rats. One month after...

.... Serotonin Acetylcholine Salbutamol Manganese chloride Alloxan Streptozotocin Diabetes mellitus Pharmacology 34; 143-148 (1987) © 1987 S. Karger AG, Basel 0031-7 0 12/87/034 3-0143S2.75/0 Decreased Gastro-Intestinal Responses to Certain Agonists in Streptozotocin- and Alloxan-Diabetic Rats in vitro...

... a low activity of aldose reductase; therefore, it is possible that MI may exert a protective effect in human diabetic cataract. Cataract Diabetes mellitus Myo-inositol Lens fiber cells Pharmacology 1989;39:59-68 © 1989 S. Karger AG. Basel 0 0 3 1-7012/89/0391-0059S2.75/0 Dietary Myo-Inositol...