...Zhiqiang Zhuang; Yuxi Zhu; Jun Tao; Yandong Liu; Jie Lin; Chunjie Yang; Chule Dong; Xing Qin; Qun Li; Russel J. Reiter; Guizhen Wang; Zhaohui Pei; Jun Ren Introduction: Diabetes mellitus is known to provoke devastating anomalies in myocardial structure and function, while effective therapeutic...

..., was recently shown to have a beneficial effect on metabolism in type 2 diabetes (T2D). Endothelial dysfunction is a key factor behind macro- and microvascular complications in T2D. The effect of sunitinib on endothelial function in T2D remains, however, unclear. We therefore tested the hypothesis...

...Chunyin Tang; Yantao Liu; Shilin Liu; Chunsong Yang; Li Chen; Fengru Tang; Fang Wang; Lin Zhan; Hong Deng; Wei Zhou; Yunzhu Lin; Xiaohuan Yuan Background: The pathobiology of diabetes and associated complications has been widely researched in various countries, but effective prevention...

...-loaded rats; antidiabetic activity was evaluated in streptozotocin (STZ)-induced diabetic rats and genetically diabetic db / db mice; the anti-dyslipidemic effect was characterized in high-fructose, high-fat diet (HFD)-fed dyslipidemic hamsters. The effect on glucose production and glucose utilization...

... studies have suggested a positive role of statins in ameliorating depression risk. However, the role of statins in the treatment of diabetes-related depression has not been well examined. Herein, we investigated the effects of lovastatin (LOV) on depressive phenotypes in streptozotocin-induced diabetic...

...Mohammad Dallak; Bahjat Al-Ani; Dina H. Abdel Kader; Refaat A. Eid; Mohamed A. Haidara Aims: We sought to determine whether insulin can protect against type 1 diabetes mellitus (T1DM)-induced cardiac ultrastructural alterations in an animal model of the disease. This has not been investigated...

...Adel Galal El-Shemi; Osama Adnan Kensara; Aiman Alsaegh; Mohammed Hasan Mukhtar Aims: This study is aimed at evaluating the antidiabetic effects of thymoquinone (TQ) on streptozotocin (STZ)-induced diabetes in rats, and exploring the possible underlying mechanisms. Methods: Diabetes was induced...

...Makoto Ohigashi; Nobuyoshi Imai; Hiroe Toba; Miyuki Kobara; Tetsuo Nakata Background/Aims: Podocytes injury is involved in the development of diabetic nephropathy. This study was designed to confirm the reno- and podocyte-protective effects of pitavastatin in diabetic rats and clarify its...

.... Analgesia Diabetes Magnesium ions N-methyl- D -aspartate receptor Morphine Rats The last 20 years have brought substantial progress in the treatment of many diseases, previously intractable by conventional therapy. In contrast, relief of neuropathic pain is still an unsatisfactorily resolved...

... and chronic treatment were investigated in a diabetic neuropathic pain (DNP) model. VFX produced a significant antihyperalgesic effect after a single and repeated administration. This effect was reversed by pretreatment with yohimbine (a relatively selective α 2 -adrenergic antagonist) and p...

... expression were upregulated in the kidneys of diabetic rats. Bradykinin (BK)-induced renal vasodilation decreased in isolated perfused kidneys of diabetic rats, but des-Arg 9 -BK-induced renal vasodilation increased. Enalaprilat also produced vasodilation in the isolated perfused kidneys of control...

... in adult patients with type 2 diabetes. Methods: A literature search (2000–2009) identified 38 placebo-controlled trials (phase II or later – parallel design) comparing exenatide (n = 8), liraglutide (n = 7), vildagliptin (n = 11) and sitagliptin (n = 12) with placebo. Outcomes were change from baseline...

...Nadia M. Hamdy; Ragia A. Taha We examined whether Nigella sativa (NS) oil and its active constituent thymoquinone (TQ) attenuate oxidative stress in the heart and brain in an experimental model of diabetes mellitus using streptozotocin (STZ). Oxidative stress was assessed by measuring cardiac...

...-IV inhibitors is being actively explored as a novel approach to the treatment of type 2 diabetes. The present study investigated the antidiabetic effects of the DPP-IV inhibitor ASP8497 in streptozotocin-nicotinamide-induced mildly diabetic mice which possess aggravation of glucose tolerance due...

... Diabetes Hyperalgesia Indomethacin L -NOArg Met-F-AEA Streptozotocin WIN 55,212-2 30 10 2007 21 03 2008 23 9 2008 © 2008 S. Karger AG, Basel 2008 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other...

... agonists and (2) the effect of the magnesium ions (Mg 2+ ) on the antinociceptive action of opioid agonists in a diabetic neuropathic pain model. When administered alone, opioid agonists like morphine (5 mg/kg i.p.) and fentanyl (0.0625 mg/kg i.p.), as well as the partial agonist buprenorphine (0.075 mg/kg...

...Johannes Schenk; Anthony Hebden; Soter Dai; John H. McNeill Blood pressure, heart rate, and left ventricular function were measured in conscious diabetic Sprague-Dawley rats subjected to 5 weeks of deoxycorticosterone acetate (DOCA) treatment which was started 1 week following intravenous injection...

...J.B. Heijnis; P.A. van Zwieten The effects of nifedipine, verapamil and diltiazem on K+-induced contraction were investigated in isolated aortic rings from diabetic and age-matched control rats. Six weeks after streptozotocin injection there was no significant difference between the maximum...

...Marta Fiol de Cuneo; Ruben D. Ruiz; Jorge L. Lacuara; Rina Santillan de Torres Conflicting reports exist about the effects of diabetes on vascular function. In the present study we investigated (1) the influences of diverse stages of diabetes on mechanical activity and pharmacological reactivity...

...S.-C.G. Hui; C.W. Ogle; Z. Wang; Y. An; Y.-H. Hu The vasodepressor responses to intravenous injections of arachidonic acid, and the formation of its metabolites, were studied in rats made diabetic 1 or 2 weeks after a 1-dose alloxan treatment. Arachidonic acid dose-dependently decreased...