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Keywords: Diabetes
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Journal Articles
Subject Area:
Pharmacology
Pharmacology (2022) 107 (3-4): 160–166.
Published Online: 20 December 2021
..., was recently shown to have a beneficial effect on metabolism in type 2 diabetes (T2D). Endothelial dysfunction is a key factor behind macro- and microvascular complications in T2D. The effect of sunitinib on endothelial function in T2D remains, however, unclear. We therefore tested the hypothesis...
Journal Articles
Journal Articles
Journal Articles
Journal Articles
Journal Articles
Journal Articles
Pharmacology (2016) 97 (5-6): 265–276.
Published Online: 25 February 2016
...Makoto Ohigashi; Nobuyoshi Imai; Hiroe Toba; Miyuki Kobara; Tetsuo Nakata Background/Aims: Podocytes injury is involved in the development of diabetic nephropathy. This study was designed to confirm the reno- and podocyte-protective effects of pitavastatin in diabetic rats and clarify its...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2014) 93 (3-4): 113–119.
Published Online: 26 February 2014
... Sigma Chemical Co., USA; morphine sulfate and magnesium sulfate from Polfa Warsaw SA, Poland. In these studies 2 models of experimental pain were used: a model of acute pain and a model of STZ-induced (diabetic) painful neuropathy. Morphine, magnesium sulfate and MK-801 were dissolved...
Journal Articles
Pharmacology (2013) 91 (1-2): 69–76.
Published Online: 22 November 2012
... and chronic treatment were investigated in a diabetic neuropathic pain (DNP) model. VFX produced a significant antihyperalgesic effect after a single and repeated administration. This effect was reversed by pretreatment with yohimbine (a relatively selective α 2 -adrenergic antagonist) and p...
Journal Articles
Pharmacology (2011) 87 (3-4): 195–203.
Published Online: 25 March 2011
... expression were upregulated in the kidneys of diabetic rats. Bradykinin (BK)-induced renal vasodilation decreased in isolated perfused kidneys of diabetic rats, but des-Arg 9 -BK-induced renal vasodilation increased. Enalaprilat also produced vasodilation in the isolated perfused kidneys of control...
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2009) 84 (3): 127–134.
Published Online: 13 August 2009
...Nadia M. Hamdy; Ragia A. Taha We examined whether Nigella sativa (NS) oil and its active constituent thymoquinone (TQ) attenuate oxidative stress in the heart and brain in an experimental model of diabetes mellitus using streptozotocin (STZ). Oxidative stress was assessed by measuring cardiac...
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2008) 82 (3): 193–200.
Published Online: 23 September 2008
..., instructions or products referred to in the content or advertisements. AM1241 Cannabinoid system CB-1 and CB-2 receptors Diabetes Hyperalgesia Indomethacin L -NOArg Met-F-AEA Streptozotocin WIN 55,212-2 Original Paper Pharmacology 2008;82:193 200 DOI: 10.1159/000156485 Received: October 30...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2008) 82 (3): 180–186.
Published Online: 14 August 2008
... agonists and (2) the effect of the magnesium ions (Mg 2+ ) on the antinociceptive action of opioid agonists in a diabetic neuropathic pain model. When administered alone, opioid agonists like morphine (5 mg/kg i.p.) and fentanyl (0.0625 mg/kg i.p.), as well as the partial agonist buprenorphine (0.075 mg/kg...
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1993) 46 (4): 193–197.
Published Online: 06 June 2008
...J.B. Heijnis; P.A. van Zwieten The effects of nifedipine, verapamil and diltiazem on K+-induced contraction were investigated in isolated aortic rings from diabetic and age-matched control rats. Six weeks after streptozotocin injection there was no significant difference between the maximum...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1988) 36 (4): 228–237.
Published Online: 05 June 2008
...Marta Fiol de Cuneo; Ruben D. Ruiz; Jorge L. Lacuara; Rina Santillan de Torres Conflicting reports exist about the effects of diabetes on vascular function. In the present study we investigated (1) the influences of diverse stages of diabetes on mechanical activity and pharmacological reactivity...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1989) 39 (5): 291–298.
Published Online: 05 June 2008
...S.-C.G. Hui; C.W. Ogle; Z. Wang; Y. An; Y.-H. Hu The vasodepressor responses to intravenous injections of arachidonic acid, and the formation of its metabolites, were studied in rats made diabetic 1 or 2 weeks after a 1-dose alloxan treatment. Arachidonic acid dose-dependently decreased...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1988) 37 (5): 281–285.
Published Online: 05 June 2008
... that hyperglycemia per se may not be the primary mechanism for the altered sensitivity to morphine in experimental models of diabetes. © 1988 S. Karger AG, Basel 1988 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages...