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Keywords: Cytochrome P450
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Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2017) 100 (5-6): 301–307.
Published Online: 19 August 2017
.... Carvedilol Citalopram Pharmacokinetics Cytochrome P450 Preclinical study Rat liver microsomes Enzyme inhibition Carvedilol is multiple-action cardiovascular drug, a nonselective beta-adrenoceptor blocker, being currently approved in many countries for the treatment of hypertension, coronary...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2016) 97 (5-6): 218–223.
Published Online: 13 February 2016
...You-ting Zhang; Da-feng Zhang; Ni-yun Ge; Guang-hui Zhu; Cong Hao; Yin Zhang; Rui-jie Chen The aim of this study was to assess the influence of evodiamine on the activities of the drug-metabolizing enzymes cytochrome P450 (CYP) 1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 in rats. The activities...
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2010) 86 (4): 203–215.
Published Online: 08 September 2010
... interactions because of their multiple mechanisms of action and/or their influence on drug-metabolizing cytochrome P450 (CYP) enzymes. Although selective serotonin reuptake inhibitors (SSRIs) and other new-generation ADs have an overall improved safety profile, their potential for drug interactions...
Journal Articles
Journal Articles
Journal Articles
Journal Articles
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1994) 48 (3): 137–142.
Published Online: 10 June 2008
.... Aztreonam Enzyme, drug-metabolizing Cytochrome P450 Microsomes Liver, monkey Original Paper Pharmacology 1994;48:137-142 Shigeru Ohmoria Toru Horieb Shin-ichi Hayashic Mitsukazu Kitada3 Division of Pharmacy, Chiba University Hospital, Faculty of Medicine, Chiba University, Chiba; Tsukuba Research...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1995) 50 (6): 348–356.
Published Online: 10 June 2008
... Inhibitors Attenuate the Hypotonic Shock-Induced Increases in K* Efflux in LLC-PK1Cells Key Words Cytochrome P450 Arachidonic acid K+ efflux LLC-PK, cells Hypoosmotic shock Abstract Cell volume regulation in LLC-PKi cells was evaluated by measuring 86Rb efflux (rate constant), used as an indicator of K...
Journal Articles
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1982) 24 (6): 355–365.
Published Online: 30 May 2008
...R.K. Jaiswal; Rama Sastry; E.J. Landon During regeneration of rat liver newly synthesized molecules of drug-metabolizing enzymes, like cytochrome P450, are incorporated into proliferating endoplasmic reticulum (ER). Decreased membrane microviscosity facilitates incorporation of the enzyme-protein...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1978) 17 (5): 262–279.
Published Online: 29 May 2008
...Kenji Kumaki; Daniel W. Nebert The spin state of cytochrome P450 ferric iron in vivo and in vitro was examined in freshly prepared liver microsomes from rabbit, guinea pig, hamster, mouse, and rat by room-temperature difference spectrophotometry. The administration of compounds which induce certain...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2000) 61 (3): 212–227.
Published Online: 13 September 2000
...Jürgen Brockmöller; Ingolf Cascorbi; Stefan Henning; Christian Meisel; Ivar Roots Studies on the role of genetically polymorphic enzymes like cytochrome P450 1A1, arylamine N-acetyltransferase 2 or glutathione S-transferase M1 as cancer susceptibility factors date back more than 20 years, and some...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2000) 61 (3): 147–153.
Published Online: 13 September 2000
... and suitable animal models to study the risks of chemical exposures in humans in terms of toxicity and carcinogenesis, as well as development and design of new therapeutic drugs. Recent studies using genetically manipulated mice are summarized. Cytochrome P450 Xenobiotic-metabolizing enzymes Gene knockout...
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1998) 56 (2): 71–79.
Published Online: 16 January 1998
... 79 Received: June 13, 1997 Accepted: August 14, 1997 Mahesh C. Sharma Meena R. Sharma Bernard H. Shapiro Laboratories of Biochemistry, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pa., USA A Comparison of Cytochrome P450-Dependent Testosterone 2·-Hydroxylase in Rat (P450...