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Keywords: Cytochrome P-450-3A
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Journal Articles
Subject Area:
Pharmacology
Journal:
Pharmacology
Pharmacology (1993) 47 (4): 268–276.
Published Online: 10 June 2008
.../ml, 0.65 µ M ), consistent with the linear (dose-independent) pharmacokinetic characteristics of ALP observed in humans. Thus formation of 4-OH-ALP via hydroxylation is the major route of ALP metabolism. This pathway is probably mediated by the cytochrome P-450-3A subfamily. Factors that impair...