...Kenneth Bachmann; Gaurab Sanyal; Jeffrey Potter; Robert Schiavone; Janette Loch The role of various subfamilies of rat hepatic cytochrome P-450 in the oxidation of theophylline was evaluated by comparing theophylline clearance in control rats and those pretreated with relatively selective inducers...

... Establishment, Gwalior, India Key Words. Carboxylesterase Cobalt chloride Cytochrome P-450 Glutathione transferase Methylcholanthrene Methyl iodide Phénobarbital Plasma proteins Soman toxicity Abstract. Rats were injected intraperitoneally with phénobarbital (PB) and 3-methylcholanthrene (MC...

...Tadahiko Fujino; Donna West; Sang S. Park; Harry V. Gelboin Four monoclonal antibodies (MAbs) to phenobarbital-induced cytochrome P-450 (PB-P-450) show different patterns of inhibition of PB-P-450 catalyzed aryl hydrocarbon hydroxylase (AHH), 7-ethoxycoumarin deethylase, benzphetamine demethylase...

... Laboratory of Molecular Carcinogenesis, National Cancer Institute. Bethesda, Md., USA Key Words. Cytochrome P-450 3-Methylcholanthrene Aryl hydrocarbon hydroxylase activity Abstract. The effect of 3-methylcholanthrene (MC) treatment on the cytochrome P-450c content of various rat tissues was examined...

...Terry J. Smith; George S. Drummond; Attallah Kappas Treatment of rats with Co-protoporphyrin, a synthetic metalloporphyrin which produces a marked and sustained induction of hepatic heme oxygenase and decline in cellular cytochrome P-450 content, caused a significant reduction in serum testosterone...

...Haider Raza; Walter G. Levine Studies were performed on the response of hepatic xenobiotic metabolizing enzymes to in vitro and in vivo exposure to amrinone and milrinone, two new inotropic compounds used in congestive heart failure. Both drugs exerted selective effects on various cytochrome P-450...

... Cytochrome P-450 Pharmacology 36: 405-410 (1988) © 1988 S. Karger AG. Basel 0 031- 7 0 12/88/O.V0405$2.75/0 Effects of Nifedipine on Hepatic Drug Oxidation T.ll. Dickinson, J.M. Egan, D.R. Abernathy Division of Clinical Pharmacology. Brown University and Department of Medicine. Roger Williams General...

...Richard C. Robinson; Robert G.L. Shorr; Angela Varrichio; Sang S. Park; Harry V. Gelboin; Haruko Miller; Fred K. Friedman A monoclonal antibody (MAb) to a rat acetone-inducible and nitrosamine-metabolizing form of microsomal cytochrome P-450, P-450ac, detected a related P-450 in human liver...

...Steven K. Clinton; Willard J. Visek Diets containing 12 or 48% of calories from corn oil were fed to weanling Sprague-Dawley female rats for 28 days. Hepatic cytochrome P-450 content was higher with the high-fat diet, but the activities of cytochrome P-450 reductase, cytochrome c reductase, benzo...

...Fred K. Friedman; Donna West; Paul M Dewick; Harry V. Gelboin The cytochromes P-450 of the mixed function oxidase system metabolize a wide variety of endogenous compounds to either nontoxic products or toxic metabolites. A number of natural products, such as flavonoids, influence this metabolism...

... or containing 20% corn oil (CO) or 20% menhaden fish oil (MO) for 4 days. PB induced soluble glutathione S-transferase, a detoxifying enzyme, only in rats fed dietary fats. Microsomes from rats fed both types of dietary fat had increased levels of cytochrome P-450 (P-450) and PB induced P-450 only in rats fed...

...E.S. Halperin-Walega; F.E. Greene To examine the role of multiple forms of cytochrome P-450 in the metabolism of endogenous substrates by lung, the oxidation of testosterone by rat lung microsomes in vitro was characterized and compared to liver. In lung, the majority of metabolism took place...

...Tanya B. Zerkle; Adelbert E. Wade Partially purified fractions of cytochrome P-450 were prepared from hepatic microsomes recovered from male rats 12 h after administration of either saline or polyriboinosinic: polyribocytidylic acid (poly I:C). Poly I:C reduced the microsomal concentration...

... as indices of glucose metabolism. Cytochrome P-450 content and NADPH-cytochrome P-450 reductase activity were assayed to reflect liver drug metabolism. Liver injury was induced by dimethylnitrosamine and carbon tetrachloride. The results demonstrate that hepatic glucose handling and drug metabolism were...

...Fred K. Friedman; Friedrich J. Wiebel; Harry V. Gelboin The microsomal cytochrome P-450-dependent aryl hydrocarbon hydroxylase is important in the detoxification of polycyclic hydrocarbons as well as their activation to cytotoxic or carcinogenic derivatives. We have studied compounds that can...

...Fred K. Friedman; Donna West; Takashi Sugimura; Harry V. Gelboin The cytochrome P-450-dependent aryl hydrocarbon hydroxylase (AHH) metabolizes a wide variety of endogenous and exogenous compounds to nontoxic metabolites and/or toxic products. We have utilized a series of 18 flavone modulators...

...Wayne L. Backes; Ingeia Jansson; John E. Mole; Gordon Gibson; John B. Schenkman Phenobarbital pretreatment of male rats induced four microsomal cytochrome P-450 enzymes, at least one of which has previously not been reported. Three of the induced forms of the cytochrome possess identical NH 2...

... was substantially enhanced in SHR rats with only slight increases in cytochrome P-450 content and aniline hydroxylase activity compared to WKY rats. The substrate-specific increases in the microsomal drug metabolism in SHR rats were accompanied by an increase in the prominence of a protein with molecular weight...

... of altered response was also seen to depend on the sex of the rat and on the substrate concentration of the incubation mixture. Dietary thiamin Cytochrome P-450 Benzo(a)pyrene hydroxylase Benzo(a)pyrene metabolites 7 10 1983 9 11 1983 4 6 2008 © 1984 S. Karger AG, Basel 1984...

... were observed in induced microsomes. Cytochrome P-450 was decreased in each case, which suggests that the metal may cause enzyme degradation. p-Nitroanisole O-demethylase was increased fivefold with both inducers. In addition, mercuric chloride increased the O-demethylase activity in relation...