... continuous subcutaneous infusion of benzodiazepines for 7 days, and the effects of several Gi-coupled receptor ligands on forskolin-stimulated cyclic AMP accumulation were examined in the cerebral cortex of mice. The mRNA expression for mGluRs was determined by RT-PCR. A single injection of flumazenil...

... or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Adenosine receptors Cyclic AMP Interleukin-8 Urinary tract infection Uropathogenic Escherichia coli Original Paper Pharmacology 2010;86:129 137 DOI: 10.1159/000317068 Received...

... in tissue culture, and their outgrowing fibroblasts were used for this study. The number of cells and their cyclic AMP content were used as parameters for cell division and for proving the selective involvement of magnesium salts in the antiproliferative effect. It is shown that the inhibitory effects...

...Harvey R. Weiss; John D. Sadoff; Peter M. Scholz; Richard E. Klabunde Nitric oxide has been shown to decrease myocardial contractility and O 2 consumption. This study was designed to evaluate the hypothesis that nitric oxide-mediated increases in cyclic GMP require elevated cyclic AMP to produce...

...Yousif I. A-Rahim; Karl H. Beyer Jr.; Elliot S. Vesell The effects of pyrazinoylguanidine (PZG) on lipolysis and intracellular cyclic AMP concentrations were investigated in isolated rat adipocytes. PZG reduced basal cyclic AMP concentrations and blocked in a concentration-dependent manner...

...Yousif I. A-Rahim; Sharon L. Rannels; Scot R. Kimball; Karl H. Beyer Jr.; Elliot S. Vesell In isolated rat adipocytes stimulated with theophylline (1 mmol/l), pyrazinoylguanidine (PZG) downregulated both lipolysis and cyclic AMP concentrations, raising the possibility that PZG stimulates adipose...

... no effect on IL-8 production. TNF-α production was inhibited more potently than IL-1β. Dibutyryl cyclic AMP (dbcAMP) also inhibited the production of TNF-α and IL-1β, but not IL-8. TNF-α production was almost completely inhibited by dbcAMP, whereas IL-1β production appeared to be partially refractory even...

... muscarinic receptors. Data from radioligand-receptor binding assays and measurements of m2 receptor-inhibited cyclic AMP formation and m3 receptor-stimulated phosphoinositide (PI) hydrolysis showed that this new series of muscarinic receptor antagonists exhibited a middle range of affinities in binding...

... accompanied by the increase in intracellular cyclic AMP levels. Thus, prostacyclin and beraprost may stimulate ciliary motility and, hence, mucociliary transport through the production of cyclic AMP. 5 07 1993 13 09 1993 10 6 2008 © 1994 S. Karger AG, Basel 1994 Copyright / Drug...

... %. With the cell yield of 1 patient a series of approximately 70 – 80 cyclic AMP measurements was possible. Histamine stimulated intracellular cyclic AMP production with an EC50 value of 35 ± 25 μmol/l (SEM; n = 4). In the presence of 100 μmol/l histamine the Ki values (μmol/l) for the histamine H2 receptor...

...) inhibitor. The results seem to indicate that in the Ca 2+ -induced cortisol secretion calmodulin may stimulate the initial stage, while C kinase may be involved mainly in the late phase of the secretion. In addition, cyclic AMP (cAMP) was also effective in activating cortisol secretion from permeabilized...

... Isoproterenol Interaction Heart rate Catecholamine Cyclic AMP 3 03 1992 1 05 1992 6 6 2008 © 1993 S. Karger AG, Basel 1993 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced...

... School of Medicine, Sagamihara, Kanagawa, Japan Key Words. Captopril Converting enzyme inhibitor Bradykinin Prostaglandin E2 Indomethacin Toad bladder Osmotic water flow Cyclic AMP Abstract. The mechanisms by which captopril inhibits vasopressin-stimulated osmotic water flow in the toad...

... coronary vessels Vascular smooth muscle Histamine receptor antagonists Adenylate cyclase potentiation Phosphodiesterase inhibition Cyclic AMP Pharmacology 1989;38:23-33 Histam ine-M ediated Vasoconstriction and cA M P Levels in Coronary Arteries of the Isolated Rabbit Heart Dale A. Schuschke, Jack...

...Shmuel Batzri; John W. Harmon The H 2 -antagonist tiotidine inhibited the H 2 -receptor-mediated, histamine-induced increase in cyclic AMP in dispersed mucosal cells from guinea pig stomach (K i , 4 × 10-8 M ). The radiolabeled [ 3 H]-tiotidine bound specifically and reversibly to the same cells...

.... Atenolol Propranolol Borderline hypertension Cyclic AMP Psychological stress Pharmacology 25: 33-38 ( 1982) Effects of Oral Atenolol and Propranolol on Blood Pressure, Heart Rate and Plasma Cyclic Adenosine 3':5'-Monophosphate in Borderline Hypertensive Patients A. Gonzälez-Gömez, D. García-Barreto...

...Kazuo Ichihara; Yasushi Abiko; Itaru Miura; Tai-ichi Nishimura The effect of a new beta-adrenoceptor agonist, ICI 118,587, on the blood levels of cyclic AMP, glucose, lactate, and FFA was studied in conscious rats. ICI 118,587 (200 μg/100 g s.c.) increased the cyclic AMP level in the normal...

...Shmuel Batzri; William F. Thompson; Raymond Toles In rabbit gastric cells the new H 2 -antagonists, BL-6341A, SK&F 93479 and L-643,441 were highly potent inhibitors of the H 2 -receptor mediated action of histamine as monitored by 14 C-aminopyrine uptake and cyclic AMP formation. BL-6341A...

...Richard F. Harty; James E. McGuigan The effects of cyclic adenosine and cyclic guanosine nucleotides and theophylline upon gastrin synthesis and secretion were examined in rat antral mucosa maintained in organ culture. In concentration-response experiments, cyclic AMP, dibutyryl cyclic AMP...

... to in the content or advertisements. Analgesia Cerebral cortex Cyclic AMP Hypothalamus Morphine Rat Tolerance Pharmacology 17: 128-137 (1978) Involvement of Brain Cyclic AMP in the Acute and Chronic Effects of Morphine in the R at1* Khadijeh S. Shahid Salles, Brenda K. Colasanti, Charles R. Craig...