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Keywords: Colonic transit
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Journal Articles
Subject Area:
Pharmacology
Pharmacology (2009) 84 (4): 227–233.
Published Online: 10 September 2009
...Ryosuke Kojima; Hitoshi Doihara; Katsura Nozawa; Eri Kawabata-Shoda; Toshihide Yokoyama; Hiroyuki Ito Although it is known that both clonidine and loperamide cause delayed colonic transit in mice, these models of drug-induced experimental constipation have not yet been fully characterized...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1993) 47 (Suppl. 1): 242–248.
Published Online: 11 June 2008
...K. Ewe; B. Ueberschaer; A.G. Press Retarded colonic transit and disturbed defecation are the most prominent pathophysiological mechanisms in constipation. Both may be influenced by bulking agents and by laxatives such as senna. Direct measurements of the influence of such substances on colonic...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2007) 81 (1): 11–17.
Published Online: 28 August 2007
... inhibition were assessed in a model of stress-induced defecation previously demonstrated to be due to increased colonic transit/evacuation. Methods: Rats were individually placed in a mild restraint cage and placed into a 12°C environment (cold-restraint stress) for 60 min. Mice received restraint (only...