...Sun Ku Lee The effect of age on the clearance (CL) of therapeutic proteins has not been explored extensively in pediatric subjects. Recently, resting energy expenditure (REE) has been proposed to link age-dependent CL with developmental changes. Allometric relationship was explored to assess...

...Kenneth Bachmann; Gaurab Sanyal; Jeffrey Potter; Robert Schiavone; Janette Loch The role of various subfamilies of rat hepatic cytochrome P-450 in the oxidation of theophylline was evaluated by comparing theophylline clearance in control rats and those pretreated with relatively selective inducers...

...Kenneth Bachmann; Jeffrey G. Sarver The objective of this investigation was to determine whether the oral clearance (CL) of chlorzoxazone could be estimated accurately from a single plasma chlorzoxazone measurement. In 6 healthy male subjects the mean clearance estimate (CL est ) from a single 6...

...Kenneth Bachmann; Chang An Chu; Vincent Greear The role of various subfamilies of rat hepatic cytochrome P450 in the oxidation of ethosuximide was evaluated by comparing ethosuximide clearance in control rats and those pretreated with relatively selective P450 inducers and/or inhibitors...

...Kenneth A. Bachmann; Jules Schwartz; Luis Jauregui; Timothy J. Sullivan; Mary Martin Clearances of phenytoin (PHT), ethosuximide, and theophylline were estimated by a single-dose, single-sample strategy in healthy, young adult men and women. PHT concentrations were measured in salivary...

...Helle Pilsgaard; Henrik E. Poulsen Antipyrine (AP) clearance was determined from AP plasma decay in 57 rats at various times after partial hepatectomy. This value for AP clearance correlated closely (r = 0.99) to AP clearance estimated from a single plasma AP concentration measured 5 h after AP...

... investigation defined more specifically the kinetics of the interaction between erythromycin and warfarin. Warfarin kinetics were evaluated in 12 normal subjects who took a single 1 mg/kg dose of warfarin with and without erythromycin. Erythromycin (250 mg p.o.) every 6 h for 8 days decreased warfarin clearance...

...Kenneth Bachmann; Jules Schwartz; Robert Forney, Jr.; Luis Jauregui Theophylline clearance was measured at 3 doses (2, 4 and 6 mg/kg) in 10 young, healthy adult subjects. Clearance decreased as the dose of theophylline increased going from 0.064 ± 0.016 to 0.052 ± 0.011 l·h –1 Kg –1 at the 2 and 6...

... predictors of the actual CL’ int /F values demonstrating a mean prediction error of-0.012 l·h –1 ·kg –1 . These data demonstrate that under specified conditions, intrinsic unbound PHT clearance can be estimated from a single PHT measurement in saliva, thereby permitting PHT to be used safely and sampled...

...Felix J. Frey; Brigitte M. Frey In order to compare total and free prednisolone clearance values following an intravenous bolus dose with those following zero-order infusions to steady state, 6 dogs were given an intravenous bolus and four different zero-order infusions of prednisolone...