...Masayuki Kitano; Kouichirou Wada; Yoshínori Kamisaki; Kentaro Nakamoto; Yosuke Kishimoto; Hironaka Kawasaki; Tadao Itoh We investigated the effects of cimetidine on acute gastric mucosal injury induced by ischemia-reperfusion in rats. Under pentobarbital anesthesia, the celiac artery was clamped...

... not to be affected during liver regeneration following treatment with the histamine H 2 receptor antagonist cimetidine (20 mg/kg/day). 21 09 1994 1 03 1995 10 6 2008 © 1995 S. Karger AG, Basel 1995 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part...

... patients. The effect of antiulcer drugs on H pylori adherence was investigated by pre-incubating isolates of H. pylori with omeprazole, cimetidine, and bismuth subcitrate. Omeprazole and cimetidine failed to significantly influence microbial adherence. In contrast, bismuth subcitrate already...

...E. Brändle; J. Greven Since in whole animal studies and in man the renal clearance of cimetidine was prolonged by the coadministration of probenecid, the aim of the present study was to examine the interaction of the organic base cimetidine with the organic anion transport system at the basolateral...

.... The effects of the anti-ulcer drugs cetraxate, cimetidine and gefarnate were examined. In ‘senders’, the gastric lesions were significantly suppressed by the administration of cetraxate at a dose of 200 mg/kg (p.o.) or cimetidine at doses of 30 and 100 mg/kg (p.o.). The gastric lesions in ‘responders’ were...

...S.L. Grainger; M.N. Nanjee; R.P.H. Thompson; N.E. Miller The effects of cimetidine (400 mg b.d.) and ranitidine (150 mg b.d.) on high-density lipoprotein (HDL) subclasses and other plasma lipoproteins were studied in 18 men and 15 women with reflux oesophagitis and/or duodenitis. Serum testosterone...

...Lamberto Re; Bernardino Di Sarra The effects of some histamine H 2 -receptor antagonists on the cholinergic system have been evaluated at the mouse end-plate. Previous data revealed interactions at both pre- and post-synaptic sites for cimetidine and ranitidine. The present work shows the effects...

...C. Netti; R. Bossa; I. Galatulas; V. Sibilia; A. Pecile Cimetidine, an H 2 receptor antagonist, administered into a lateral ventricle of the rat brain caused a significant increase in tail flick latency. Dimaprit, a specific H 2 agonist, failed to counteract the analgesic effect of cimetidine...

...A.M. Cheret; C. Scarpignato; M.J.M. Lewin; G. Bertaccini The effect of cimetidine and two new histamine H 2 -receptor antagonists, oxmetidine and SKF 93479, on histamine-stimulated adenylate cyclase activity was studied in guinea pig gastric mucosal cells. Histamine stimulated the enzyme activity...

...Carmelo Scarpignato; Piero Del Soldato Intraperitoneal, but not intravenous administration of dimaprit (50–125 mg/kg) caused a dose-dependent writhing in the rat. This effect was blocked, again in a dose-dependent fashion, by cimetidine administered orally 1 h prior to dimaprit. Results obtained...

... of the applications of histamine, blocked the vasoconstriction, indicating an 3 H-receptor-mediated response. Cimetidine, perfused during one of the applications of histamine, enhanced the vasoconstriction, indicating that H 2 -receptors mediate an inhibition of vasoconstriction. Cimetidine perfused during all...

...G. Perret; J.N. Hugues; M. Louchahi; O. Varoquaux; E. Modigliani Cimetidine (400 mg b.d.), ranitidine (150 mg b.d.) and placebo were administered for 1 week to 6 healthy male volunteers in a randomized double-blind cross-over fashion. Hormonal concentrations before and after a TRH test were...

... potentiating action. Atropine (0.5 mg/kg, s.c.) and cimetidine (12.5–25 mg/kg, s.c.) decreased the ulcerogenic activity of indometacin, and the combination of indometacin/morphine in about the same degree. However, the reduced ulcerogenic activity of indometacin after atropine or cimetidine treatment could...

...Moshe Garty; Aryeh Hurwitz Gastric administration of cimetidine, 5 mg/kg, and magnesium aluminum hydroxide gel (Maalox®), 1 ml/kg, were equally effective in raising the gastric pH of mice from 2.5 to 5.0. The antacid depressed by 75% gastrointestinal absorption of tetracycline given by gastric tube...

... of cimetidine up to 10 –3 mol/l. Acetylcholine-induced acid secretion was not influenced by hexamethonium. In the mouse isolated stomach, acetylcholine stimulates acid secretion through a direct cholinergic pathway. 28 07 1979 6 01 1980 30 5 2008 Isolated whole stomach Mouse Acid...

...Thomas E. Tenner, Jr. In an effort to compare the H 2 receptors responsible for the chronotropic and vasorelaxant effects of histamine, rabbit right atria and aortae were studied using four H 2 receptor agonists and the H 2 receptor antagonist cimetidine. While the efficacies of the various...

... to the Billroth method. AC in biopsies from cimetidine-treated peptic ulcer patients was less sensitive to adrenaline than AC in biopsies from untreated patients. The threshold concentration of cimetidine to inhibit adrenaline-stimulated AC in vitro was 10 –6 mol/l. The data provide evidence of an adrenaline...

...C. Scarpignato; G. Valenti; G.P. Ceda; G. Bertaccini Cimetidine infused intravenously into 6 healthy volunteers did not induce significant changes in plasma levels of prolactin (hPRL), thyreotropin (hTSH), gonadotropin (hLH and hFSH) and growth hormone (hGH). Conversely it caused a significant...