...H. Lorković; U. Jäger Contractures evoked by 0.1 mmol/l acetylcholine (ACh) in bundles from mouse soleus muscles denervated for 3-7 days were partly inhibited for more than 1 h following 2- to 10-min exposure to 10-100 µmol/l chlorpromazine (CP). The effect was stronger in sucrose than in Na...

...Yoshio Ohmiya; Harihara M. Mehendale Our previous studies have demonstrated that chlorpromazine (CPZ) and imipramine (IMP) are metabolized appreciably via N-oxidation catalyzed by pulmonary microsomal flavin monooxygenase in the rat but not in the rabbit. The present work deals with the species...

...A.S. Salhab; C.A. Dujovne Isolated rat hepatocytes were used to determine the relationship between magnitude of uptake by cells and cytotoxic effects of chlorpromazine (CPZ) and promazine (PZ). Cell injury was evaluated by the extent of leakage of cytoplasmic and lysosomal enzymes from cells...

..., pregnenolone acetate, deoxycorticosterone acetate, tamoxifen and SKF 525-A exerted markedly different concentration-dependent inhibitions of intestinal and liver AHH activities. The most potent inhibitors of AHH activity were captan, BHA, chlorpromazine, thioridazine, disulfiram and menadione. The ability...

...Tomoaki Morita; Harihara M. Mehendale Previous work indicates that one consequence of the accumulation of several xenobiotics in the lung is compromised pulmonary disposition of 5-hydroxytryptamine (5-HT). In the present studies, we examined whether pulmonary accumulation of chlorpromazine (CPZ...

... by a rapid distribution phase (t1/2 = 2 min) and a slower elimination phase with a clearance of 22.4 ml/min (t ½ = 47 min). Addition of chlorpromazine (1 mg) at 30 min was followed by a twofold increase in perfusate concentrations of 3 H-propranolol which was also associated with a reduction of 3 H...

...I. Tarnawa; J.I. Székely Using a discrete-trial avoidance-escape schedule in rats the interactions of morphine (M), chlorpromazine (C) and haloperidol (H) were studied. All three drugs given alone or in combination disrupted operant behavior. At low doses C and H potentiated each other’s effect...

... on the binding of hexokinase activity to mitochondria of brain, liver and neuroblastoma cells was studied in vitro. Solubilization of hexokinase activity was achieved in all systems at therapeutically relevant thiopental concentrations. On the other hand, chlorpromazine as a highly lipophilic drug only...

.... This biphasic effect on temperature was similar to that seen with THC at 0.5 mg/kg, thus adding further evidence of a similarity in the mode of action of the two drugs. In contrast, only hypothermia was evident following chlorpromazine administration. 28 07 1978 7 08 1978 29 5 2008 © 1979...

..., caffeine, thiopental, and chlorpromazine by enhancing their level in the brain. Peptides from 120 min digestion were more effective. A possible mechanism of observed changes has been discussed. 22 11 1974 29 5 2008 © 1975 S. Karger AG, Basel 1975 Copyright / Drug Dosage / Disclaimer...

...Gene C. Palmer; David J. Jones; Miguel A. Medina; Jo Palmer; William B. Stavinoha The norepinephrine (NE)-induced accumulation of cyclic AMP in incubated tissue slices of mouse lung was inhibited by chlorpromazine (CPZ) and to a lesser extent by haloperidol. In particulate lung fractions both...

...Roger Drew; Brian G. Priestly The effects of subacute administration of chlorpromazine HCl (CPZ), erythromycin base and erythromycin estolate on the cholestatic response to intravenous taurolithocholate (TLC) and taurochenodeoxycholate (TCDC) in the rat were investigated. All three enhanced...

... or modulation of CPZ hypothermia. 9 06 1978 29 06 1978 29 5 2008 Chlorimipramine p-Chlorophenylalanine Chlorpromazine 5,6-Dihydroxytryptamine Hypothermia Lilly 110140 Nialamide Raphe neuron Serotonin Tryptophan Pharmacology 18: 128-135 (1979) Effects of Brain Serotonin...

...M. Babbini; M. Gaiardi; M. Bartoletti The effects of chlorpromazine and fluphenazine on behavior and electroencephalogram (EEG) have been studied in rats in order to find out whether quantitative surface EEG can be reliably used to assess the degree of hypnotic sedative activity of neuroleptic...

...I. Ueda; A. Kohama; W.S. Jordan; C.L. Graves In dogs, a dose of chlorpromazine 25 mg/kg given in 10 min lowered the mean femoral arterial pressure 60% during pentobarbital anesthesia and 70% during methoxyflurane anes thesia. Calcium chloride 0.2 mEq/kg given in 10 min reversed the hypotension...

...S.C. Chou; S. Ramanathan; P. Heu; K.A. Conklin Chlorpromazine (CPZ) inhibits synchronized cell division in Tetrahymena pyriformis with 100% inhibition occurring at 8 µg/ml. CPZ markedly inhibited the incorporation of precursors into DNA and RNA, but had little effect on the incorporation of acetate...

... reactions. The compound does not exert an anti-arthritic action. 1 02 1971 28 5 2008 Adjuvant arthritis Benzoctamine (Tacitin) Chlorpromazine Diazepam Paw oedema (kaolin, glass, carrageenin) Turpentine pleurisy © 1971 S. Karger AG, Basel 1971 Copyright / Drug Dosage...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Arachidonic acid peroxide Chlordiazepoxide Chlorpromazine Imipramine Phenyl- p -benzoquinone Pharmacology 6: 35-40 (1971) The Antinociceptive Action of a Novel...

...H. Helfer; R. Jaques Using the isolated spontaneously pulsating portal vein of the mouse, it was shown that benzoctamine differs from chlorpromazine and imipramine with regard to its effect on pulsatile frequency and excursions (amplitude). 1 02 1971 28 5 2008 © 1971 S. Karger AG...

...M.S. Ebadi Chlorpromazine Pyridoxal phosphate Pyridoxine phosphate oxidase Pyridoxal kinase 11 08 1969 27 5 2008 1970 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced...