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Keywords: Carvedilol
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Journal Articles
Subject Area:
Pharmacology
Pharmacology (2017) 100 (5-6): 301–307.
Published Online: 19 August 2017
...Maria Bianca Abrudan; Dana Maria Muntean; Daniela Saveta Popa; Ana-Maria Gheldiu; Maria Adriana Neag; Laurian Vlase Background/Aims: The aim of this study was to investigate the drug-drug interaction between carvedilol and citalopram based on carvedilol metabolism in vitro and his pharmacokinetics...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2017) 99 (3-4): 139–143.
Published Online: 05 January 2017
...Maria Bianca Abrudan; Dana Maria Muntean; Ana Maria Gheldiu; Maria Adriana Neag; Laurian Vlase Background/Aims: The effects of multiple-dose bupropion on the pharmacokinetics of single-dose carvedilol were investigated in order to evaluate this possible drug-drug interaction. Methods: A preclinical...
Journal Articles
Journal Articles
Pharmacology (2016) 97 (1-2): 31–37.
Published Online: 17 November 2015
... drug (carvedilol) in rats or human is still unknown. The present work was to study the impact of apatinib on the metabolism of carvedilol both in vitro and vivo. Methods: A specific and sensitive ultra-performance liquid-chromatography tandem mass spectrometry method was applied to determine...
Journal Articles
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2012) 90 (3-4): 117–124.
Published Online: 18 July 2012
...Nobumitsu Hanioka; Sawako Tanaka; Yushi Moriguchi; Shizuo Narimatsu Background and Purpose: Carvedilol is used clinically as a β-adrenoceptor antagonist for the treatment of chronic heart failure and is primarily metabolized into glucuronides by UDP-glucuronosyltransferase (UGT). In this study...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1994) 48 (6): 385–391.
Published Online: 10 June 2008
...Ron Feuerstein; Tian-Li Yue The antioxidant activity of SB209995, a metabolite of carvedilol in human, was studied and compared with its parent compound, carvedilol. SB209995 or carvedilol inhibited iron-catalyzed lipid peroxidation assessed as thiobarbituric acid-reactive substance generated...
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1997) 54 (1): 24–32.
Published Online: 10 June 2008
...Giora Z. Feuerstein; Marc Fisher; J. Nunnari; Robert R. Ruffolo, Jr. The effects of carvedilol, a vasodilating β-blocker with antioxidant activity, and nifedipine, a calcium channel blocker, were investigated on aortic lipid deposition and the accumulation of monocytes and foam cells at the sites...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1991) 43 (3): 113–120.
Published Online: 06 June 2008
...Steven A. Hamburger; Frank C. Barone; Giora Z. Feuerstein; Robert R. Ruffolo, Jr. Carvedilol (Kredex®) is a multiple action, antihypertensive agent that may also prove to be useful in the treatment of angina and congestive heart failure. Carvedilol combines in one molecule both β-adrenoceptor...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1990) 41 (4): 200–206.
Published Online: 05 June 2008
...Miklos Gellai; Robin DeWolf; Robert R. Ruffolo, Jr. The effects of the novel antihypertensive agent, carvedilol, on renal hemodynamics and excretory function have been investigated and compared with the effects of labetalol in conscious, spontaneously hypertensive rats. Sustained intravenous...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1989) 39 (5): 327–336.
Published Online: 05 June 2008
...Andrew J. Nichols; Anthony C. Sulpizio; Daryl J. Ashton; J. Paul Hieble; Robert R. Ruffolo, Jr. The pharmacologic profile of the novel β-adrenoceptor antagonist/vasodilator, carvedilol, has been investigated in vitro. Carvedilol produced competitive antagonism of the β 1 -adrenoceptor mediated...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2007) 80 (2-3): 166–176.
Published Online: 04 June 2007
...Frank C. Barone; Robert N. Willette; Allen H. Nelson; Eliot H. Ohlstein; David P. Brooks; Robert W. Coatney Background/Aims: Histological studies have provided evidence that carvedilol can prevent cardiac hypertrophy in spontaneously hypertensive-stroke prone rats (SP) fed a high-fat and -salt diet...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2007) 80 (2-3): 144–150.
Published Online: 29 May 2007
... the precise mechanisms remain unclear. The present study evaluates the effect of β-blockade with carvedilol (1 mg/kg/day) on cardiovascular function in 2- and 6-month-old cardiomyopathic hamsters (SCH) after 1-month and 5-month treatment periods with the drug, respectively. Age-matched golden hamsters were...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2007) 79 (2): 86–92.
Published Online: 07 December 2006
.... This study was conducted to investigate whether the beneficial effects of carvedilol involve modulation of respiratory burst, degranulation-myeloperoxidase release and inducible nitric oxide synthase (iNOS) expression. Methods: Spectrophotometry and chemiluminescence were used to evaluate the effect...
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1998) 56 (1): 30–36.
Published Online: 08 January 1998
... - and/or β 2 -adrenoceptors in the heart. Drugs with ISA are particularly problematic in the treatment of congestive heart failure since agents that activate cardiac β-adrenoceptors, such as xamoterol, have been associated with increases in the incidence of arrhythmia and mortality. Carvedilol was recently...