..., to have a variety of effects on cartilage repair processes in diseased articular cartilage. The aim of this study was to ascertain the effects of meloxicam on some of these processes using in vitro models. Acetylsalicylic acid, a NSAID whose characteristics have been previously elucidated in the models...

...Jürgen Steinmeyer; Sabine Daufeldt; Dieter A. Kalbhen Matrix metalloproteinases (MMPs) belong to the key enzymes of the proteolytic destruction of cartilage matrix during chronic rheumatic diseases. Our work focused on the inhibitory potential of the hydroxamate Ro 31-4724 on the activity of MMP...

...D.A. Lowther; C.J. Handley; A. Gundalach An organ culture system was used to study the metabolic effects of exposure of articular cartilage to increasing concentrations of salicylic acid. It was shown that concentrations of salicylate above 1 mM inhibited the incorporation of 35 S-sulphate...