... of the sulfhydryl subclass. To assess its value as a new therapeutic agent, we performed a comparative analysis of the effect of TBTIF versus captopril on the circulating levels of angiotensin (Ang) peptides and bradykinin as well as ACE and ACE2 expression after myocardial infarction. Male Wistar rats were divided...

... treated with captopril (5 mg kg –1 day –1 for 7 days; n = 6). Phenylephrine (PHE) concentration-response curves were constructed (1 × 10 –9 to 3.1 × 10 –5 mol/l) and α 1A -, α 1B - and α 1D -AR were measured in the aorta by immunoblot. Captopril decreased α-AR expression in the NP group. In contrast...

... of STZ (45 mg/kg in 0.05 mol/l sodium citrate buffer). Diabetic rats were divided into five groups. Each group received by gavage for 24 weeks one of the following: vehicle (saline 10 ml/kg, b.i.d.), PZG (35 mg/kg, b.i.d.), captopril (15 mg/kg, b.i.d.), or hydrochlorothiazide (HCTZ, 20 mg/kg, b.i.d...

...Jagdish N. Sharma; Siti S. Amrah; Abdul R. Noor The present investigation evaluated the effects of aprotinin, an inhibitor of kallikrein, on blood pressure responses, heart rate, and duration of hypotension induced by acute administration of captopril and enalapril (angiotensin-converting enzyme...

...Satoru Suzuki; Hirokazu Sato; Hisaki Shimada; Noriko Takashima; Masaaki Arakawa The free radical scavenging effects of an angiotensin-converting enzyme (ACE) inhibitor containing sulfhydryl (SH; captopril) were compared with those of ACE inhibitors not containing SH (enalapril, enalaprilat...

...Fumiaki Marumo; Yoshihiro Nara The mechanisms by which captopril inhibits vasopressin-stimulated osmotic water flow in the toad bladder have been investigated in vitro. Captopril has two possible mechanisms for the inhibitory action on the water flow, one is its stimulative effect on prostaglandin...

...Barbara Malinowska; Włodzimierz Buczko In pithed rats intravenous administration of serotonin (5.0, 10.0, 20.0, 30.0 and 50.0 μg/kg) produced a dose-dependent increase in blood pressure. The pressor response to serotonin was significantly reduced by captopril (1.0, 5.0 and 50.0 mg/kg) in a dose...

...Katsuhiko Noguchi; Takayuki Kato; Ryuji Sunagawa; Matao Sakanashi The regional hemodynamic effects of MC-838, a new angiotensin-converting enzyme inhibitor, and captopril at equidepressor doses were examined in the anesthetized dog by simultaneously measuring renal (RBF), coronary (CBF), vertebral...

...Melvin J. Fregly; Ora E. Lockley; Charles E. Simpson 42 female rats (230–260 g) made hypertensive by bilateral renal encapsulation with latex envelopes were divided into three equal groups. Two groups were administered the angiotensin-converting enzyme inhibitor captopril (SQ 14,225) in drinking...

...S.Alyssa Mueller; WilliamJ. Driscoll; GregoryP. Mueller The therapeutic actions of captopril are facilitated by its sulfhydryl moiety which interacts with the metal (Zn 2+ ) prosthetic groups of angiotensin-converting enzyme (ACE; EC 3.4.15.1). This study focused on captopril as an inhibitor...

...Shawn C. Black; Edward M. Driscoll; Benedict R. Lucchesi Cardioprotective effects of the angiotensin-converting enzyme inhibitors captopril and ramiprilat were studied in two in vivo canine models of myocardial ischemic injury: 90 min of regional ischemia with 18 h reperfusion (protocol I) and 6 h...

...Barbara A. Olson; Shujath M. Ali; Lisa C. Contino; David P. Brooks; Nicholas J. Laping The effect of the angiotensin-converting enzyme inhibitor captopril on clusterin mRNA was examined in partially nephrectomized male rats. Urine protein excretion was measured 3, 7, and 28 days after removal...