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Keywords: Capsaicin
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Journal Articles
Subject Area:
Pharmacology
Pharmacology (2019) 104 (3-4): 207–211.
Published Online: 12 July 2019
..., but not in the ileum, was significantly reduced by in vitro capsaicin desensitization. In the bladder A967079 or the TRPV1 antagonist, BCTC failed to reduce the response. A direct relaxation on the smooth muscle was detected in the precontracted ileum. In the precontracted urinary bladder, CNA also caused relaxation...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2018) 101 (5-6): 290–297.
Published Online: 27 March 2018
... the efficacy of topical capsaicin 8% in peripheral neuropathic pain in a routine clinical setting. Methods: Therapeutic efficacy was evaluated through pain intensity, using numerical pain rating scale at baseline and 7–14 days after each treatment, and using pain treatment area (PTA) assessed immediately...
Journal Articles
Journal Articles
Journal Articles
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2011) 88 (1-2): 82–87.
Published Online: 16 August 2011
...Jiexian Liang; Guanqing Xiao; Wenjin Ji We investigated whether capsaicin induces itching in skin with existing inflammation. We induced skin inflammation by intradermal injection of complete Freund’s adjuvant (CFA) in the neck of mice. Four days later, we injected capsaicin in the same area...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2011) 87 (3-4): 152–154.
Published Online: 22 February 2011
...Masahisa Shindo; Yuichi Yoshida; Osamu Yamamoto Capsaicin, a vanilloid, has the potential for releasing substance P (SP) from sensory nerves. Topical application of capsaicin induces a flare response in the skin. However, it has not been clarified whether the release of SP is involved...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2009) 83 (2): 116–121.
Published Online: 19 December 2008
...) in culture, nefopam (3–30 μmol/l) and capsazepine (TRPV1 antagonist, 10 μmol/l) prevented intracellular calcium elevation and calcitonin gene-related peptide release induced by vanilloid agonist capsaicin. Unlike nefopam, capsazepine failed to inhibit these same responses induced by KCl excess. In vivo...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1997) 54 (3): 127–134.
Published Online: 10 June 2008
...Yi-Ching Lo; Wann-Chu Huang; Ing-Jun Chen Effects of glyceryl nonivamide (GLNVA), a nonpungent analogue of capsaicin, on spinal substance P release, blood pressure and renal function were investigated in rats. GLNVA was administered intrathecally or intracerebroventricularly, and renal clearance...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2005) 73 (3): 121–128.
Published Online: 04 February 2005
...Omar M.E. Abdel Salam; Ola A. Heikal; Siham M. El-Shenawy Capsaicin is a popular food ingredient. This study aimed to determine if capsaicin can affect bile flow and bile protein secretion, and the extent to which capsaicin can reach bile in the rat. The effect of capsaicin was studied...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2004) 72 (1): 51–56.
Published Online: 06 August 2004
... antagonist, and capsaicin inhibited LPA-induced ISRs. Additionally, LPA-induced ISRs were abolished by Y-27632, an inhibitor of Rho-associated protein kinase (ROCK). These findings suggest that LPA-induced ISRs are attributable to histamine- and substance-P-mediated pathways. Moreover, the Rho/ROCK-mediated...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2004) 70 (3): 152–159.
Published Online: 30 January 2004
...M.N. Gaspar; C.A. Fontes Ribeiro; J.G. Cunha-Vaz; T.R.A. Macedo The purpose of this work was to study ‘in vivo’ the vascular responses of retinal vessels of New Zealand white rabbits to substance P (SP), neurokinin A (NKA), neurokinin B (NKB), senktide, capsaicin (CAPS), and calcitonin gene related...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2003) 69 (1): 38–43.
Published Online: 06 August 2003
...Sebastian D. Vulcu; Johanna Rupp; Caroline Wiwie; Clemens Gillen; Ruth Jostock; Hermann Nawrath The vanilloid receptor 1 (VR1) is a heat-activated cation channel which also responds to capsaicin and other chemical stimuli. Protein kinase C has a stimulatory effect on VR1 activity, either alone...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2002) 64 (2): 57–62.
Published Online: 10 January 2002
... muscle. When the neurokinin A (NKA) antagonist MEN-10376 was administered after indometacin, the beta-adrenoceptor-evoked response was completely abolished. The isoproterenol-evoked beta response was dose dependently reduced following treatment with the capsaicin antagonist ruthenium red. Taken together...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (2000) 60 (1): 1–8.
Published Online: 07 January 2000
...Anders Franco-Cereceda; Jan Liska A subpopulation of capsaicin-sensitive cardiac C-fibre afferents co-store calcitonin gene-related peptide (CGRP), substance P and neurokinin A. CGRP exerts positive inotropic and chronotropic effects and is one of the most potent endogenous vasodilators yet...
Journal Articles
Subject Area:
Pharmacology
Pharmacology (1999) 58 (1): 24–33.
Published Online: 03 December 1998
..., electrical field stimulation induced a frequency-dependent tetrodotoxin-sensitive relaxation. The relaxation was biphasic, consisting of fast and slow phases. The fast component was attenuated by propranolol, indicating an action on β-adrenoceptors. The slow phase was attenuated by capsaicin and, therefore...