...S.K. Tilak; A.M. Zimmerman Effects of Δ9-tetrahydrocannabinol (THC), cannabinol (CBN) and cannabidiol (CBD) (1, 3 or 5 μ M for 2 h) on macromolecular synthesis were investigated in homogeneous populations of pachytene spermatocytes and round spermatids obtained from CD-1 mice. Incorporation of 3H...

...W.O.T. Baczynsky; A.M. Zimmerman The effects of the cannabinoids Δ 9 -tetrahydrocannabinol (THC), cannabinol and cannabidiol on the primary humoral immune response, the secondary humoral immune response and the memory aspect of humoral immunity in response to sheep red blood cell (SRBC...

...W.O.T. Baczynsky; A.M. Zimmerman The effects of the cannabinoids, Δ 9 -tetrahydrocannabinol (THC), cannabinol (CBN) and cannabidiol (CBD), on the primary-like immune response were investigated in primary cultures of mouse splenocytes. Splenocyte cultures were stimulated with sheep erythrocytes...

...), cannabinol or cannabidiol at a dose of 10 mg/kg, the percentage of micronuclei in cannabinoid-treated mice was 3- to 5-fold greater than in the dimethyl sulfoxide controls. In the acute series, polychromatic erythrocytes were scored after a single exposure. In one acute series there was an approximately...

... scored in the light microscope and assessed in the scanning electron microscope. The animals treated with Δ 9 -tetrahydrocannabinol (Δ 9 -THC) and cannabinol (CBN) had a statistically higher incidence of abnormal sperm than the controls. The incidence of abnormal sperm in the animals treated...

...Isac G. Karniol; Itiro Shirakawa; Reinaldo N. Takahashi; Elias Knobel; Richard E. Musty The interaction of Δ 9 -tetrahydrocannabinol (Δ 9 -THC) and cannabinol (CBN) was studied in man. Five male volunteers were given placebo, 50 mg CBN, 25 mg Δ 9 -THC, 12.5 mg Δ 9 -THC + 25 mg CBN, and 25 mg Δ 9...

... individuals and DNA repair deficient Xeroderma pigmentosum patients display similar survival activity upon exposure to THC. There was no observable increase in the number of chromosome breaks or chromatid exchanges following exposure to THC or THC plus S9 microsomal fraction. THC, 11-OHΔ 9 -THC, cannabinol...

... but not for cannabidiol at 25 mg/kg or cannabinol at 25 mg/kg. The mice were given four daily doses (i.p.) of either drug or vehicle (Tween 80-propylene glycol in 1 % saline) or a single injection (i.p.) of sheep red blood cells in addition to four daily doses (i.p.) of drug or vehicle. Suppression of the antigenic...

...N.K. McCallum A new method for estimating cannabinols in blood after marihuana smoking has enabled quantitation of Δ 9 -tetrahydrocannabinol and cannabinol. A preliminary finding is of an unexpectedly high level of cannabinol. 23 08 1973 28 5 2008 © 1974 S. Karger AG, Basel 1974...