...Christopher A. Legare; Wesley M. Raup-Konsavage; Kent E. Vrana Background: There is a growing interest in the use of cannabis (and its extracts), as well as CBD oil (hemp extracts containing cannabidiol), for therapeutic purposes. While there is reason to believe that cannabinoids may...

... actions on cannabinoid receptors 1 and 2, and may also include central actions. In summary, in agreement with the ancient use of cannabis in intestinal disturbances and one decade of animal research, cannabis was shown in a clinical trial to reduce symptoms in patients with Crohn's disease. This elegant...

...Sanjay Mandhane; Prasanta Nayak; Durgesh Soni; Shakti Jain; John C. Ashton; Thennati Rajamannar Background/Aims: Rimonabant is a cannabinoid CB1 receptor antagonist. Other CB1 antagonists have biphasic effects on blood glucose levels following acute administration. We therefore tested the effects...

...Birgit Kraft Cannabis sativa is one of the oldest crops cultivated for the production of fibers and for medical and recreational purposes. Since the detection of specific cannabinoid receptors and their physiological ligands, the understanding of the cannabinoid signalling system has increased...

... that in addition to intraperitoneal application, intrarectal delivery of cannabinoids may represent a useful therapeutic administration route for the treatment of colonic inflammation. 13 01 2012 18 01 2012 12 3 2012 © 2012 S. Karger AG, Basel 2012 Copyright / Drug Dosage / Disclaimer...

...Donna A. Whyte; Suleiman Al-Hammadi; Ghazala Balhaj; Oliver M. Brown; Harvey S. Penefsky; Abdul-Kader Souid Background and Purpose: The primary cannabinoids, Δ 9 -tetrahydrocannabinol (Δ 9 -THC) and Δ 8 -tetrahydrocannabinol (Δ 8 -THC) are known to disturb the mitochondrial function and possess...

... inflammation or nerve injury. Inhibitory postsynaptic transmission in the adult spinal cord involves mainly glycine. HU210 is a non-psychotropic, synthetic cannabinoid. As we hypothesized that non-CB receptor mechanisms of HU210 might contribute to its anti-inflammatory and anti-nociceptive effects we...

... Accepted: November 27, 2008 Published online: February 10, 2009 The Nonpsychotropic Cannabinoid Cannabidiol Modulates and Directly Activates Alpha-1 and Alpha-1-Beta Glycine Receptor Function Jörg Ahrensa Reyhan Demira Martin Leuwerc Jeanne de la Rochea Klaus Krampflb Nilufar Foadia Matthias Karsta Gertrud...

...João R. Araújo; Pedro Gonçalves; Fátima Martel Folic acid (FA) is an essential micronutrient that is particularly important during pregnancy for normal placental and fetal development and growth. The placenta and the fetus become frequently exposed to drugs of abuse such as cannabinoids because...

..., quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Cannabinoids Natural killer cells Cytokines Tetrahydrocannabinol, tolerance...

... in the acid-insoluble fraction. Pachytene spermatocytes and round spermatids isolated from THC-treated mice (10 and 20 mg/kg) showed no reduction in macromolecular synthesis compared to cells isolated from vehicle-treated mice. Suppression of macromolecular synthesis induced by in vitro cannabinoid treatment...

...% at the high CME or THC dose and was correlated with decreased food intake. When cannabinoid was administered early in the light cycle (9–11 a.m.), cauda epididymis sperm count and seminal vesicle fluid and fructose content were depressed to 50–65% at the high dosages but were not significantly different from...

...W.O.T. Baczynsky; A.M. Zimmerman The effects of the cannabinoids Δ 9 -tetrahydrocannabinol (THC), cannabinol and cannabidiol on the primary humoral immune response, the secondary humoral immune response and the memory aspect of humoral immunity in response to sheep red blood cell (SRBC...

...W.O.T. Baczynsky; A.M. Zimmerman The effects of the cannabinoids, Δ 9 -tetrahydrocannabinol (THC), cannabinol (CBN) and cannabidiol (CBD), on the primary-like immune response were investigated in primary cultures of mouse splenocytes. Splenocyte cultures were stimulated with sheep erythrocytes...

... and high dosages, respectively. After a 30-day recovery period, 80% of those females that failed to have successful pregnancies now became pregnant. 20 10 1979 26 10 1979 30 5 2008 Cannabinoids Mice Estrous cycles Reproduction Progesterone Δ 9 -Tetrahydrocannabinol Ovulation...

...Kenneth M. Johnson; William L. Dewey; Alan S. Bloom Acute administration of certain cannabinoids, including Δ 9 -tetrahydrocannabinol (Δ 9 -THC), resulted in elevated levels of plasma corticosterone in mice. The rank order potency of these cannabinoids is the same as others have reported using...

... to altered serum androgen levels since these levels 2–6 h after last treatment were 0.15, 0.77 and 3.33 ng/ml for THC, pair-fed and ad libitum-fed groups, respectively. 24 h after the last treatment all groups were within normal levels. Thus, chronic cannabinoid treatment suppresses accessory sex organ...

...A.M. Zimmerman; Yesoda Raj Chromosomal and nuclear aberrations in bone marrow cells were studied in hybrid mice of genotype (C57BL x C3H)F 1 following treatment with specific cannabinoids. In the subacute series, mice were treated for 5 consecutive days with Δ 9 -tetrahydrocannabinol (THC...

...Arthur M. Zimmerman; Robert Bruce; Selma Zimmerman Sperm morphology was studied in hybrid mice of genotype (C57BL x C3H)F 1 following treatment with specific cannabinoids. Mice were treated for 5 consecutive days with the specific cannabinoid; 35 days after the last treatment, epididymal sperm were...

... or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Cannabidiol Cannabinoids...