...Roberto Frussa-Filho; Maria do Carmo Monteiro; Carla G.S. Soares; Rosane Cury Décio We determined the effect of 13 days of treatment with 2.0 mg/kg haloperidol, 4.0 mg/kg bromocriptine or 2.0 mg/kg amphetamine on the number of tumor cells of mice bearing Ehrlich ascites carcinoma. The dopaminergic...

...Gaetano Di Chiara; Maria Luisa Porceddu; Lidia Vargiu; Gian Luigi Gessa Bromocriptine produces long-lasting hypomotility and decreases brain dihydroxyphenylacetic acid (DOPAC) in mice. These effects are obtained with doses much lower than those which produce hypermotility. The decrease of brain...

...M. Goldstein; A. Lieberman; A.F. Battista; J.Y. Lew; F. Hata The antiparkinsonian activity of bromocriptine and of lergotrile was investigated in monkeys with surgically induced tremor and in parkinsonian patients. Both drugs effectively relieve tremor in experimental monkeys and induce less...

...F. Silvestrini; A. Liuzzi; P.G. Chiodini The effects of ergot alkaloids (mainly bromocriptine) on the secretion of GH and PRL in normal subjects and in pathological conditions (i.e. acromegaly and hyperprolactinemic states) are discussed. In the normal subjects, bromocriptine releases GH whereas...

...J.M. Vigouret; H.R. Bürki; A.L. Jaton; P.E. Züger; D.M. Loew Neurochemical and neuropharmacological investigations with four ergot derivatives reveal differential pharmacodynamic effects of these compounds. Bromocriptine and CM 29–712 showed actions typical of postsynaptic dopamine receptor...

...G. Pepeu; P. Mantovani The effect of bromocriptine on acetylcholine (ACh) output from the cerebral cortex was investigated in anaesthetized rats. Bromocriptine caused a brief decrease in ACh output at the dose of 0.1 mg/kg i.p. and a dose-related long-lasting increase at doses from 1.25 to 10 mg/kg...

...P. Portaleone We compared the effects of bromocriptine and of hydergine on striatal and hypothalamic adenylate cyclase activity. Rats treated with bromocriptine (5 mg/kg) or with hydergine (3 mg/kg), showed a stimulation of adenylate cyclase activity in the striatum, but not in the hypothalamus...

...V.G. Longo; A. Loizzo The effects of some ergot derivatives on the electroencephalogram and behavior of laboratory animals (mice, rats, rabbits) have been surveyed. The interference of bromocriptine on the dopaminergic central systems has been studied using behavioral (interference with the effects...