...Ritsuko Okamoto; Yoshinori Itoh; Yusuke Murata; Daisuke Kobayashi; Masako Hosoi; Kazunori Mine Prolonged use of benzodiazepines often leads to dependence and withdrawal syndrome. However, the cellular mechanisms underlying benzodiazepine dependence have not been fully clarified. Several...

...Berit X. Carlson; Helen A. Baghdoyan The present study used saturation binding analyses to test the hypothesis that pentobarbital would differentially increase the affinity of benzodiazepine binding across brain regions. The results showed that there were significant (p < 0.05) regional...

...(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Alprazolam Benzodiazepines In vitro metabolism Cytochrome P-450-3A Species comparison Hydroxylation Original Paper...

... be useful for the treatment of benzodiazepine oversedation and overdose. 22 08 1991 30 10 1991 6 6 2008 © 1992 S. Karger AG, Basel 1992 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages...

..., instructions or products referred to in the content or advertisements. γ-Aminobutyric acid type A receptors Benzodiazepines Cardiorespiratory depression Original Paper Pharmacology 1992;45:154-161 Angelo M. Taveira Da Silva Stuart Pineo Richard A. Gillis Department of Medicine and Pharmacology...

...Edward O. Bixler; Anthony Kales; Barbara H. Brubaker; Joyce D. Kales The rates of reported adverse drug reactions involving the central nervous system were compared among patients taking any of three benzodiazepine hypnotics: flurazepam, temazepam, and triazolam. These rates, based upon data...

... to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Flurazepam Benzodiazepines CSF entry Pharmacokinetics Pharmacology 36: 166-171 (1988) Pharmacokinetics and CSF Entry of Flurazepam in Dogs Hermann R. Ochs, David J...

.... Chlordiazepoxide Benzodiazepines Antipyrine Pharmacokinetics Geriatrics Pharmacology 1989;38:327-334 Age and Gender Effects on Chlordiazepoxide Kinetics: Relation to Antipyrine Disposition David J. Greenblatt, Marcia K. Divoll. Darrell R. Abernelhy, Hermann R. Ochs, Jerold S. Harmatz, Richard I. Shader...

...Anthony Kales; Constantin R. Soldatos; Edward O. Bixler; Joyce D. Kales Rebound insomnia and rebound anxiety are clinical conditions related to withdrawal of certain benzodiazepine drugs. Numerous studies of benzodiazepine and nonbenzodiazepine hypnotics conducted in our sleep laboratory...

...David J. Greenblatt; Marcia Divoll; Darrell R. Abernethy; Ann Locniskar; Richard I. Shader Three benzodiazepine derivatives are currently indicated specifically for the treatment of insomnia in the United States. Flurazepam is biotransformed to at least two rapidly appearing and rapidly eliminated...

...W.M. Bourn; R.L. Garrett; K.M. Tolson Flurazepam, a clinically proven and widely accepted sedative hypnotic, has been shown by a number of investigators to produce convulsions at toxic doses. In the present study, CGS-8216, a benzodiazepine receptor antagonist, reduced the dose of flurazepam...

... or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Benzodiazepines Midazolam Pharmacokinetics Hydroxy metabolites Gas...

... to in the content or advertisements. Flunitrazepam Benzodiazepines Induction agents Gas chromatography Pharmacokinetics Pharmacology 24: 82-87 (1982) Automated Electron-Capture Gas Chromatographic Analysis of Flunitrazepam in Plasma David J. Greenblatt, Hermann R. Ochs, Ann Locniskar. Peter M. Lauven...

... to in the content or advertisements. Chlordiazepoxide Benzodiazepines Liquid chromatography Pharmacokinetics Original Papers Pharmacology 24: 261-266 (1982) Liquid Chromatographic Determination of Chlordiazepoxide and Metabolites in Plasma1 Marcia Divoll, David J. Greenblalt. Richard I. Shader Division...

... absorption Benzodiazepines Drug interactions Pharmacokinetics Ethanol © 1981 S. Karger AG, Basel 1981 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means...

... ; Benzodiazepines Drug metabolism Pharmaco­ kinetics Liver - Radiation Abstract. Biotransformation of chlordiazepoxide was studied in mice following a single 1000-rad dose of hepatic irradiation. Metabolic rV-demethylation of chlordiazepoxide in irradiated mice was impaired when tested 3 days after irradiation...

... and phagocytosis were inhibited by the peripheral benzodiazepine receptor (PBR) antagonist PK11195 (10 µmol/l). The PBR agonist Ro5-4864 (10 nmol/l to 10 µmol/l) did not affect migration but slightly enhanced phagocytosis, while clonazepam, which binds to the central-type benzodiazepine receptors but has...

...H.C.Y. Yen; S. Krop; Halina C. Mendez; M.H. Katz Pharmacology 3: 32 40 (1970) Neurotic behavior, cats Meprobamate Benzodiazepines Barbiturates Phenothiazines Haloperidol D-Amphetamine Effects of Some Psychoactive Drugs on Experim ental N eurotic (C onflict In d u ced ) B ehavior in Cats H. C.Y...

...Henna Oittinen; Heinz Rameis; Alois Saria; Gerald Zernig Fixed combinations of a tricyclic antidepressant (TCA) with a benzodiazepine (BZD) for the treatment of depressive syndromes enjoy remarkable acceptance among patients and prescribing physicians. In order to investigate if the widespread use...