... E 2 (2 µg/paw). Neostigmine (8 µg) increased the nociceptive threshold only in the treated paw, suggesting only a local effect. The muscarinic antagonist atropine (150, 300 and 600 µg) caused a reduction in the nociceptive threshold induced by carrageenan (125 µg/paw), but not by prostaglandin E 2...

... of yohimbine and naloxone, respectively. Tegaserod, a gastrointestinal motor-stimulating drug, reversed the delay in both models, but the effects were diminished at high doses. Atropine, an antispastic drug, improved the loperamide-induced delay, but did not affect the clonidine-induced delay. Mustard oil...

...O. Karádi; O.M.E. Abdel-Salam; B. Bódis; G. Mózsïk The protective effect of ‘chemical vagotomy’ (atropine given in three doses: 0.1, 0.5 and 1.0 mg/kg i.p.) was examined on indomethacin (IND, 20 mg/kg s.c.)-induced macroscopic gastrointestinal (GI) mucosal erosions and changes of vascular...

... Cholinergic Receptors in Cat Pons and Cortex Preliminary Study Key Words REM sleep Pontine reticular formation 4-DAMP AF-DX 116 Pirenzepine Atropine Abstract Muscarinic receptors (mAChRs) in the pontine reticular for­ mation comprise a critical part of the REM sleep-generating system. Although the role...

.... Hufforda, S.A. Elmarakbya. L.A. Walkerb Departments o f 3Pharmacognosy and bPharmacology, Research Institute of Pharmaceutical Sciences, University of Mississippi, University, Miss., USA Key Words. Carbachol Antimuscarinic Acetylcholine Isolated atrial preparation Atropine Bornaprine Anti...

... a transient increase in blood pressure followed by sustained hypotension, bradycardia and respiratory depression in a dose-dependent manner. Fatalities were observed over a 150-min observation period and were a function of dose. Pretreatment with atropine sulfate (1 mg/kg i.v.) produced an accentuated...

...C.H. Cho; C.W. Ogle The role of the cholinergic nervous system in ethanol-induced gastric mucosal damage has been examined in rats. Oral administration of 50 or 80% ethanol produced haemorrhagic lesions which were reduced by atropine pretreatment (0.65, 2.5, 5 or 10 mg/kg injected i.p...

... previously implanted hypothalamic cannulae. Administration of TRH or pilocarpine into the lateral cerebral ventricle or the anterior hypothalamus caused a dose-related increase in gastric volume and acidity in rats. On the other hand, administration of either atropine or D-tubocurarine into the same brain...

...Luigi Molinengo; Piera Ghi Modifications of acetylcholinesterase (AChE) activity, caused by diisopropylfluorophosphate (DFP) and atropine and their synergism, were determined in vitro and in vivo in the rat. In vitro atropine caused a reduction of the AChE activity, but reduced the enzyme...

... mucosa. Further studies will be necessary to determine which of the muscarinic receptors potentially involved in the regulation of acid secretion is responsible for the M1-behavior of this pathway. Atropine Pirenzepine Telenzepine Muscarinic receptors Gastric mucosa Pharmacology 1988;37(suppl 1...

...M. Del Tacca; G. Soldani; C. Bernardini; E. Martinotti Concentration-response curves of bethanechol were obtained from isolated guinea pig gastric fundus and gastric circular smooth muscle strips before and after exposure to pirenzepine or atropine. In the presence of pirenzepine and atropine...

... pentobarbital alone and 90% higher than the control. Mecamylamine (0.5 mg/kg) given intraperitoneally 15 min prior to nicotine resulted in blood glucose concentrations near the control value. Atropine (2 mg/kg) administered intraperitoneally did not prevent the hyperglycemia induced by nicotine...

...L. Molinengo; M. Orsetti This study concerns the effects of strychnine and caffeine on ethanol, pentobarbital and atropine-induced depression of mouse motility and of frog spinal reflex. Competitive antagonism was found for the interaction between caffeine and ethanol, caffeine and pentobarbital...

... receptors on shaking response and the effects of carbachol on central catecholaminergic, serotonergic (5-HT) and GABAergic functions were studied in rats. The muscarinic receptor antagonists, atropine and scopolamine attenuated WDS produced by carbachol, whilst a peripherally active muscarinic receptor...

... potentiating action. Atropine (0.5 mg/kg, s.c.) and cimetidine (12.5–25 mg/kg, s.c.) decreased the ulcerogenic activity of indometacin, and the combination of indometacin/morphine in about the same degree. However, the reduced ulcerogenic activity of indometacin after atropine or cimetidine treatment could...

... acetylcholine, carbachol and pilocarpine resulted in an increase in plasma immunoreactive insulin levels accompanied by a significant fall in blood glucose levels. Nicotine had no effect. Carbachol was found to enhance insulin release in a dose-dependent manner. Muscarinic blockade by atropine or methylatropine...

...I. Szelenyi; H. Vergin The isolated whole stomach of the mouse has been used to study the effect of atropine on gastric acid secretion stimulated by acetylcholine, bethanechol and histamine. Atropine inhibited acid secretory response to acetylcholine and bethanechol in a competitive manner...

... intravenous injection of norepinephrine in the dog. Accordingly, in 7 dogs the gracilis muscle was isolated and perfused and the reflex evoked. The analysis of the integrated areas of vasodilatation after atropine pretreatment showed a significant decrease of the reflex response in the perfused circulation...

... observed after flash injections of methacholine, pentagastrin or electrical stimulation of the Latarjet nerve. These reactions were dose-dependent. Tetrodotoxin, atropine, hexamethonium and glucagon, when given as constant infusion, did inhibit the action of Maxeran on myoelectrical and mechanical...

... currents was abolished by atropine. Rats anesthetized with urethane were generally more responsive to hypo thalamic stimulation than those anesthetized with amobarbital. Stimulation thresholds were significantly lower when rats were awake than when they were anesthetized with either anesthetic. In some...