...Xiufang Jiang; Yanling Lei; Yajuan Yin; Fangfang Ma; Mingqi Zheng; Gang Liu Introduction: Fisetin has been demonstrated to inhibit the occurrence of atherosclerosis; however, the mechanism of fisetin suppressing atherosclerosis remains elusive. Methods: The function of fisetin in the inhibition...

..., the occurrence of cardiovascular disease is still a global concern. The transcription factor 21 (TCF21) plays an important role in cardiovascular diseases. This article reviews the regulation mechanism of TCF21 expression and activity and focuses on its important role in atherosclerosis in order to contribute...

...Yan Lu; Hanlin Zhang; Min Han; Ping Wang; Liping Meng Introduction: Hyperuricemia may be involved in the phenotypic transformation of vascular smooth muscle cells, thus promoting the occurrence of atherosclerosis, and autophagy may be one of the important links, but little is known about...

... and this interaction was required to suppress AR activity. Conclusions: The Daxx-mediated antagonism of AR depicts a more complete picture as to how Daxx regulates intracellular cholesterol level and provides a new target for treatment of atherosclerosis. [email protected] HepG2 cells were seeded into 60-mm...

...Yu-Ping Yang; Mo-Li Zhu; He-Yun Zhang; Ping Song; Jian Xu; Peng Li; Ya-Ling Yin Atherosclerosis (AS) is a chronical pathological process of the arterial narrows due to the AS plaque formation. The aim of this study was to explore the therapeutic effect and the underlying mechanism of Floralozone...

...Magdalena Borowska; Marzena Dworacka; Anna Wesołowska; Hanna Winiarska; Ewa Krzyżagórska; Grzegorz Dworacki Background: The aim of this study was to assess the impact of pharmacotherapy of diabetes on atherosclerosis, as reflected in interleukin (IL)-1β, IL-6 and IL-10 serum levels. Methods: We...

... by transmetallation by zinc. The released manganese rapidly clears from the blood and is taken up by the hepatocytes which increase the signal intensity of the normal liver tissue. The excretion of manganese is through the biliary route whereas the fodipir metabolites are renally excreted [ 5 ]. Atherosclerosis...

... 2010 19 11 2010 Aspirin ATP-binding cassette transporter A1 Cholesterol efflux Atherosclerosis Peroxisome proliferator-activated receptor-α © 2010 S. Karger AG, Basel 2010 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part of this publication may...

...Wei Yan; Tongxin Zhang; Jun Cheng; Xiangdong Zhou; Xiaolong Qu; Houyuan Hu Background: Liver X receptors (LXRs) promote macrophage reverse cholesterol transport and cholesterol excretion from the body. The synthetic LXR ligands T0901317 and GW3965 were shown to significantly inhibit atherosclerosis...

... or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements. Atherosclerosis Coronary artery...

...-year treatment with rosuvastatin (10 mg/day). Methods and Results: Forty-five patients with hypercholesterolemia and asymptomatic carotid atherosclerosis on baseline carotid ultrasound investigation (CUI) were examined with repeat CUI after 1 year of treatment (rosuvastatin 10 mg/day). Demographic...

... drug. L -Carnitine is a pivotal molecule in fatty acid oxidation pathways and its regulation in vasculature might be a promising approach for antiatherosclerotic treatment. This study was performed to evaluate the effects of mildronate treatment on the progression of atherosclerosis and the content...

..., instructions or products referred to in the content or advertisements. Carvedilol Nifedipine β-Blockers Atherosclerosis Hypercholesterolemia Pharmacology Original Paper Pharmacology 1997;54:24-32 Received: August 9,1996 Accepted: October 16, 1996 Giora Z. Feuerstein Marc Fishera J. Nunnarib Robert...

...M.T.R. Subbiah; R. Yunker Effect of high doses of estrogen administration early in life on aortic atherosclerosis and cholesteryl ester metabolism was investigated in female atherosclerosis-susceptible (White Carneau) pigeons. Long-term estrogen (in doses of 0.25 mg/kg/day) administration...

.... These observations may open a new avenue for the pharmacological development of agents capable of improving the patterns of blood flow in patients with circulatory impairments. Fibrinogen Fibrinolysis Blood flow Coronary heart disease Atherosclerosis Tissue perfusion Hypolipidemic agents © 1981 S...

... Sciences and Drug Research, Punjabi University Patiala, Patiala, and bI.S.F. Institute of Pharmaceutical Sciences and Drug Research, Moga, Punjab, India Key Words Peroxisome proliferator activated receptors Atherosclerosis Vascular remodeling Endothelial dysfunction Hypertension Cardiac...

... cell endocytosis of CuZn-SOD, possibly via activation of a receptor-mediated pathway. Intracellular uptake via endocytosis may contribute to the vascular effects of CuZn-SOD, including vasodilation, and is likely to play a role in regulation of vascular tone and diseases such as atherosclerosis. ©...

...Yukiko Ichida; Goji Hasegawa; Michiaki Fukui; Hiroshi Obayashi; Mitsuhiro Ohta; Aya Fujinami; Kiyoe Ohta; Koji Nakano; Toshikazu Yoshikawa; Naoto Nakamura Resistin is a novel cysteine-rich protein that plays a role in the development of insulin resistance and atherosclerosis. HMG-CoA reductase...

... of the above classes of drugs on the uptake of modified low-density lipoprotein (LDL) by U937 cells (human monocytic cell line), a key event in the progression of atherosclerosis. U937 cells were treated with drugs and subsequently the uptake of fluorescent acetylated LDL was assessed by flow cytometry...

... findings that dihydropyridine calcium antagonists increase endothelial NO formation as well as studies which demonstrate these effects in vivo both in animals and humans. Moreover, the influence of dihydropyridine calcium antagonists on the progression of atherosclerosis is discussed. These pleiotropic...