... of an aqueous spray-dried extract of Salvia rosmarinus Spenn . (rosemary) in an ovalbumin-induced asthmatic rat model. Methods: Rats were randomly divided into normal control (control), asthma, asthma+rosemary extract (RE) (13 mg/kg), asthma+RE (50 mg/kg), and asthma+budesonide groups. After 50 days, animals...

... tissues of asthmatic mice. Anti-asthma role of quercetin is related to periostin. Then deeper mechanical study revealed that inhibiting TGF-β1 could improve asthmatic symptoms, and quercetin exerted the protective effect on asthmatic mice through inhibition of TGF‐β1/Smad pathway. Conclusion: Quercetin...

...Zibierguli Zhakeer; Maierbati Hadeer; Zumulaiti Tuerxun; Kelibiena Tuerxun Asthma is an inflammatory airway disease characterized by increased infiltration of inflammatory cells into the airways and poor respiratory function. Bufalin is one of the biological ingredients obtained from Chansu...

...Nour A. Al-Sawalha; Brian J. Knoll The effect of stains in asthma is mediated through targeting several signaling molecules that are involved in the development of asthma phenotype. In vitro and in vivo studies revealed that statins reduce airway smooth muscle cells proliferation and inflammatory...

...Emily V.S. Ha; Duncan F. Rogers Background: In asthma and chronic obstructive pulmonary disease (COPD), airway mucus hypersecretion contributes to impaired mucociliary clearance, mucostasis and, potentially, the development of mucus plugging of the airways. Summary: Excess mucus production can...

...Yanming Lu; Yaqin Li; Lingyun Xu; Min Xia; Lanfang Cao Aims: To assess the efficacy of conventional treatment combined with bacterial lysate [OM-85 Broncho-Vaxom (BV)] in the prevention of asthma in children as well as its influence on the number of natural killer T (NKT) cells and their cytokine...

...Gioacchino Calapai; Marco Casciaro; Marco Miroddi; Fabrizio Calapai; Michele Navarra; Sebastiano Gangemi Background: Montelukast, a leucotriene receptor antagonist, binds the cysteinyl leucotriene type 1 receptor. Montelukast is commonly prescribed to asthma patients as add-on therapy to inhaled...

...Yu-Ying Qiu; Jin-Xiao Zhu; Tao Bian; Fei Gao; Xiu-Feng Qian; Qiang Du; Min-Yu Yuan; Hua Sun; Ling-Zhi Shi; Ming-Hong Yu Bronchial asthma is characterized by chronic lung inflammation, airway hyperresponsiveness, and airway remodelling. Astragaloside IV (3-O-β- D -xylopyranosyl-6-O-β- D...

...Fei Gao; Dong Wei; Tao Bian; Ping Xie; Jian Zou; Huijun Mu; Bin Zhang; Xiaoyan Zhou Background: Genistein, a flavonoid in legumes and some herbal medicines, has various biological actions. Previous studies have shown that genistein decreased airway inflammation in allergic asthma. However, studies...

.... Results: Of 548 patients with asthma, chronic obstructive pulmonary disease or respiratory muscle weakness, 107 were taking theophylline (median serum concentration 8.1 µg/ml). The theophylline users were older (mean 64.5 ± 11.6 vs. 56.5 ± 16.8 years, p < 0.01), had severer airway obstruction (p...

...Yuhua Yang; Jenny Ying-Lin Lu; Xiaosu Wu; Shamin Summer; John Whoriskey; Christiaan Saris; Jeff D. Reagan We report that the asthma drugs cromolyn disodium and nedocromil sodium are potent G-protein-coupled receptor 35 (GPR35) agonists. We utilized calcium flux and inositol phosphate accumulation...

... and the spleen, and it has been studied a lot elucidating its role in the etiology of airway inflammation and asthma. On the other hand, CysLT 2 receptors are present in the heart, brain and adrenal glands. This review discusses the role of CysLTs and their receptor in the pathophysiology of various inflammatory...

... is critical to the modulation of inflammatory response generation. Phosphodiesterase 4 (PDE4), an enzyme that catalyzes cAMP degradation, is therefore being actively explored as a molecular target for the treatment of airway inflammation, particularly asthma and chronic obstructive pulmonary disease...

... SP-induced Evans blue dye extravasation at the trachea and main bronchi. These results suggest that cilostazol might reduce airflow obstruction which is seen in diseases such as asthma through attenuation of bronchoconstriction and, possibly, airway edema resulting from airway microvascular leakage...

... effect of other antiasthmatic agents. Therefore, Y-24180 would be a clinically promising drug for the treatment of bronchial asthma. 2 09 1996 19 10 1996 10 6 2008 © 1997 S. Karger AG, Basel 1997 Copyright / Drug Dosage / Disclaimer Copyright: All rights reserved. No part...

... in models of arthritis, pain, myocardial injury, sepsis and asthma; all of which have an inflammatory component. SD-282 represents a valuable tool to elucidate the role of p38 MAP kinase in multiple models of inflammation. p38 MAP kinase Inflammation Cytokine Asthma Sepsis 10 04 2007 13...

... with asthma, and thrombin has been shown to increase the permeability of endothelial cell monolayers. Therefore, we suspected that thrombin affects airway permeability. Calu-3 cell monolayers were established on microporous membranes of tissue culture cell inserts. We examined the effects of topically applied...

...M.H. Boskabady; M.R. Aslani; A. Tabatabaei There are reports regarding harmful effect of long-term use of β 2 -agonist drugs on asthma severity and airway responsiveness. In the present study, the responses of guinea pig trachea with intact and denuded epithelium (groups 1 and 2, n = 10...

...Katsumi Ikezono; Masayuki Kamata; Toyoki Mori While the guinea pig has been the preferred choice for use as a model of allergic bronchial asthma in the evaluation of anti-asthmatic drugs, it has been shown that antigen-induced bronchoconstriction in guinea pigs is attenuated by epinephrine released...

...M.H. Boskabady; A. Zarei Despite the controversy of bronchial responsiveness to β 2 -agonist drugs in asthma, in a previous study we have shown increased responsiveness of asthmatic tracheobronchial tree to isoprenaline. Therefore, in the present study, tracheal responsiveness to isoprenaline...