... pharmacodynamic interactions of PPIs and antiplatelet drugs with respect to cardiovascular risk. Patients with BCR::ABL1-negative myeloproliferative neoplasms (MPNs), essential thrombocythemia (ET), and polycythemia vera (PV) often suffer from peptic ulcer disease (PUD) and frequently receive low-dose aspirin due...

... by acetylsalicylic acid (ASA, aspirin) is missing. It is well known that the antiplatelet effects of ASA and clopidogrel are frequently impaired (high on-treatment platelet reactivity [HTPR]). In this pilot investigation, we compared the antiplatelet effects of clopidogrel versus ASA. Methods: In this retrospective...

... permanent oral ASA medication is frequently applicated. The impact on platelet reactivity and clinical events is not known. In this pilot study, we aimed to analyze high on-treatment platelet reactivity (HTPR) to aspirin in patients undergoing elective PCI. Platelet reactivity was measured using light...

...Lisa Dannenberg; Daniel Metzen; Saif Zako; Martin Pöhl; Philipp Mourikis; Carolin Helten; Kajetan Trojovsky; David Naguib; Daniel Konsek; Betül Knoop; Aysel Ayhan; Thomas Hohlfeld; Tobias Petzold; Bodo Levkau; Verena Veulemans; Tobias Zeus; Malte Kelm; Amin Polzin Aspirin is indispensable...

...Amin Polzin; Lisa Dannenberg; Theresa Schneider; Betül Knoop; David Naguib; Carolin Helten; Martin Pöhl; Malte Kelm; Tobias Zeus; Thomas Hohlfeld Aspirin is essential in secondary prevention of patients after myocardial infarction and with coronary artery disease. However, impaired pharmacodynamic...

...Amin Polzin; Betül Knoop; Andreas Böhm; Lisa Dannenberg; Mark Zurek; Tobias Zeus; Malte Kelm; Bodo Levkau; Bernhard H. Rauch Background: Aspirin plays a crucial role in the prevention of cardiovascular diseases. We previously described that aspirin has effects beyond inhibition of platelet...

...Jing Zhang; Huanchun Song; Shuying Jiang; Zhibin Chen; Shuhua Tong; Feiyan Lin; Congcong Wen; Xiuhua Zhang; Lufeng Hu Background: Aspirin and ibuprofen are the most frequently prescribed non-steroidal anti-inflammatory drugs in the world. However, both are associated with a variety of toxicities...

...Annemarie Mohring; Kerstin Piayda; Lisa Dannenberg; Saif Zako; Theresa Schneider; Kirsten Bartkowski; Bodo Levkau; Tobias Zeus; Malte Kelm; Thomas Hohlfeld; Amin Polzin Platelet inhibition by aspirin is indispensable in the secondary prevention of cardiovascular events. Nevertheless, impaired...

...Eugenia C. Yiannakopoulou A previously healthy 60-year-old man receiving aspirin for primary prevention of cardiovascular disease presented with hemoptysis after 1 week of treatment for his back pain with diclofenac. He had not suffered from any bleeding episode in the past and his family history...

... investigated the effect of aspirin on this process. Methods: The expression levels of ABCA1 in RAW264.7 cells were determined using reverse transcription polymerase chain reaction and Western blot analysis. 3 H-cholesterol efflux was measured by scintillation counting. Results: 0.5 mmol/l aspirin increased...

...Yinan Hua; Jie Xue; Fan Sun; Lujia Zhu; Meilin Xie Recently, aspirin has been shown to alleviate matrix metalloproteinase (MMP) expression, but the underlying mechanism is still unclear. In this study, the effects of aspirin on oxidative low-density lipoprotein (ox-LDL)-stimulated human monocyte...

..., instructions or products referred to in the content or advertisements. Aspirin Indomethacin Tartrazine Carotid-sinus nerve Pressoreceptors Guinea pig Pharmacology 34: 96-103 (1987) © 1987 S. Karger AG. Basel 0031 -7012/87/0343-0096S2.75/0 Aspirin, Indomethacin, and Tartrazine Increase Carotid...

...Harold M. Silberman The effectiveness and safety of suprofen 200 mg, aspirin 650 mg, and placebo in the treatment of moderate to severe pain were compared in a 72-hour multiple-dose, double-blind, parallel, randomized study in 75 adults suffering from musculoskeletal pain. Suprofen was superior...

...Abraham Sunshine; Ivan Marrero; Nancy Z. Olson; Eugene M. Laska; Nilda McCormick The purpose of this study was to evaluate the analgesic efficacy and safety of single oral doses of suprofen 200 and 400 mg, compared with aspirin 650 plus codeine 60 mg, aspirin 650 mg, and placebo in the relief...

...Robert F. Willkens The safety and efficacy of suprofen 200 mg q.i.d. and aspirin 650 mg q.i.d. in the treatment of chronic pain due to osteoarthritis were compared in a double-blind, randomized, parallel group study over a 12-week period. Suprofen was comparable to aspirin in the relief of pain...

...Stephen A. Cooper; Barry Wagenberg; Robert Eskow; Jeffrey Zissu A double-blind, randomized, parellel group, placebo-controlled study was carried out to compare the safety and efficacy of single doses of suprofen (200 mg and 400 mg) with aspirin (650 mg) and placebo in relieving pain. In patients...

...John D. Arnold; Arthur E. Berger The effects of aspirin and suprofen on gastrointestinal blood loss were compared in a double-blind, crossover study of 20 healthy male subjects. Fecal blood loss was measured by 51 Cr-labeled red cells. Subjects treated with aspirin (2,600 mg/day) experienced a mean...

... by bicuculline and picrotoxin. Pretreat-ment with inhibitors of prostaglandin synthesis such as aspirin (3 × 10 –6 to 3 × 10 –4 M ) and indomethacin (3 × 10 –6 M ) reduced the contractile response to GABA in an irreversible manner and without affecting the relaxation induced by GABA. These inhibitors increased...

...D. Shields; C. Marra; A. Goodwin; Joan Vernikos-Danellis The effect of environmental temperature on the toxicity of cyclizine, tri-methobenzamide, and Aspirin® were studied in mice. LD 50 s were compared at 30 °C (warm), 22 °C (normal), and 15 °C (cool). At 30 °C the toxicity of all three drugs...

...K. Kowalewski; T. Pachkowski; D.C. Secord Principal glycoproteins and amino acids of secretions from Heidenhain pouches were studied in control and aspirin-treated dogs in the resting state of fasting and during stimulation with pentagastrin. All samples showed the presence of galactose...