...Larry R. Engelking; Jeanne Lofstedt; Gershwin T. Blyden; David J. Greenblatt The following studies were designed to evaluate plasma elimination kinetics of intravenously administered antipyrine, acetaminophen and lidocaine among 9 healthy adult horses and 9 healthy drug-free humans (3 each per drug...

... the metabolism of propranolol and another high clearance drug, lidocaine, and of the low clearance drug antipyrine, was studied in isolated rat hepatocytes. For comparative purposes, the influence of the enzyme inhibitor SKF 525A (100 mg/kg i.p.) was also evaluated. Turpentine pretreatment of the rats...

...T.H. Dickinson; J.M. Egan; D.R. Abernethy To determine whether inhibition of drug oxidation is a general property of all calcium antagonist drugs or just of a few, we measured effects of therapeutic doses of nifedipine on antipyrine biotransformation. Antipyrine was administered in random order...

...Joseph M. Scavone; David J. Greenblatt; Barbara W. LeDuc; Gershwin T. Blyden; Becki G. Luna; Jerold S. Harmatz The effect of cigarette smoking on drug oxidation and conjugation was studied using antipyrine and acetaminophen as marker compounds. For the antipyrine study, healthy cigarette smokers (n...

...David J. Greenblatt; Marcia K. Divoll; Jerold S. Harmatz; Richard I. Shader Twelve young (24–41 years) and 11 elderly (62–77 years) volunteer subjects received a single 1.0-gram dose of antipyrine on three occasions: intravenously, orally in the fasting state and orally following a standard...

... subjects who received a single 1.0- to 1.2-gram intravenous dose of antipyrine on another occasion, clearance of chlordiazepoxide and of antipyrine were significantly correlated (r = 0.62, p < 0.01). Like many other low-clearance oxidatively metabolized compounds, chlordiazepoxide clearance is reduced...

...Helle Pilsgaard; Henrik E. Poulsen Antipyrine (AP) clearance was determined from AP plasma decay in 57 rats at various times after partial hepatectomy. This value for AP clearance correlated closely (r = 0.99) to AP clearance estimated from a single plasma AP concentration measured 5 h after AP...

...V.K. Shukla; S.K. Garg; V.S. Mathur A study was conducted to see the effect of 15- and 30-day corticosteroid therapy (prednisolone 0.25 mg/kg/day) on the metabolism of antipyrine and chloramphenicol in rabbits. Antipyrine and chloramphenicol were given to rabbits orally at doses of 20 and 50 mg/kg...

...Hermann R. Ochs; David J. Greenblatt; Birgitt Verburg-Ochs; Darrell R. Abernethy; Martin Knüchel Factors influencing hepatic oxidation of antipyrine and conjugation of acetaminophen were evaluated in volunteers who received 1.0 g of antipyrine intravenously and on a different occasion a 650 mg...

... suspected to have produced hepatic microsomal enzyme induction, causing unusually high theophylline clearance. The intravenous antipyrine test demonstrated an unusually short half-life (5.5 h) and high clearance (95 ml/min) of antipyrine, consistent with induced clearance of antipyrine. Formation of the 4...

...Kenneth Bachmann; Jules Schwartz; Robert Forney, Jr.; Gerald Sherman; Luis Jauregui The possibility that oral cholestyramine treatment might indirectly increase hepatic drug oxidations was investigated in rats using pentobarbital, antipyrine, zoxazol-amine, and aminopyrine as probes of the hepatic...

...Monica Valentovic; Kenneth Bachmann Hexobarbital sleep times, antipyrine-induced temperature depression, in vitro hexobarbital metabolism, and antipyrine half-life were measured in rats receiving either saline or urea pre treatments. Urea pretreatment slows hexobarbital metabolism and prolongs...

...M. Eichelbaum; B. Sonntag; H.J. Dengler A high-performance liquid chromatography method is described which allows for the simultaneous determination of antipyrine, 4-hydroxyantipyrine, norantipyrine and 3-hydroxyantipyrine. Hydrolysis conditions with respect to source of glucuronidase, amount...

...A.P. Van Peer; K.M. Belpaire; M.T. Rosseel; M.G. Bogaert Concentrations of antipyrine, phenylbutazone and phenytoin were measured in serum and in tissues of rabbits with acute renal failure after uranyl nitrate injection, in view of our earlier finding that the volume of distribution of phenytoin...

... to the increase of the volume of distribution found for these drugs in renal failure as already suggested by our in vivo data in the preceding paper. 17 07 1979 6 06 1980 30 5 2008 Antipyrine Phenylbutazone Phenytoin Renal failure Serum binding Tissue binding Pharmacology 22: 146...

...Carol A. Shively; Richard J. Simons; Elliot S. Vesell A method using gas chromatography with organic nitrogen-sensitive detection is described for measurement of antipyrine and aminopyrine concentrations in biological fluids. The analysis was performed isothermally on 3% SP-2250 DB after...

...K. O’Malley; I.H. Stevenson; M. West The effect of fenfluramine, administered orally in a daily dose of 1 mg/kg for 40 days, on the disposition and rate of elimination of antipyrine was studied in 15 obese patients. Although the plasma half-life of antipyrine was unchanged, the apparent volume...

...Charles R. Clark; Shirley J. Gee; Robert I. Krieger Pretreatment of 3 male rhesus monkeys ( Macaca muhtta ) with SKF 525-A(20 mg/kg, i.m.) 3 h prior to injecting 14 CH 3 -N-antipyrine (30 mg/kg, i.v.) increased antipyrine plasma half-life (APH) 240–500%; measurements of APH made 4, 8 and 11 days...

...Achiel Van Peer; Frans Belpaire; Marc Bogaert Serum protein binding and serum levels of antipyrine, phenytoin and phenylbutazone were measured in rabbits with acute renal failure induced by uranyl nitrate. The kinetics of antipyrine are not altered in the uraemic rabbit. Serum protein binding...

...Elliot S. Vesell; Thomas Passananti; Patricia A. Glenwright Disulfiram inhibited antipyrine metabolism reproducibly in three experiments utilizing three different groups of normal human volunteers. In these experiments disulfiram in a dose of 3.5 mg/kg body weight was given orally twice daily for 4...